Ceruloplasmin im Serum der Leberzirrhosen

Hauftová, D; Slaviček, Jasna

doi:10.1159/000202366

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1963

DOI: 10.1159/000202366

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Ceruloplasmin im Serum der Leberzirrhosen

D Hauftová¹,

Jasna Slaviček²

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1967

1969

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“…The increased oxidase activity in the serum of patients with cirrhosis or in hepatic coma has been related to the rise in blood copper in cirrhosis [ Recently Hauftova and Slavicek reported, instead, a fall in the level of serum oxidase activity in patients with hepatic cirrhosis : this fall would seem to be proportional to the reduction in serum albumin [13]. Although reporting a rise in serum oxidase activity in cirrhotics, Walshe [40] also observed a marked reduction in the same activity in the course of chronic and fatal hepatitis, presumably owing to failure of the synthetic functions of the liver.…”

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confidence: 99%

Ceruloplasmin Activity in Liver Diseases Quantitative Determination and Electrophoretic Characterization

Gc¹,

Petrella²,

Lomanto³

et al. 1967

Enzymol Biol Clin

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Ceruloplasmin activity has been studied in normal subjects and in patients suffering from early and advanced cirrhosis, acute hepatitis, hepatic neoplasms and in hepatic coma. A significant increase in oxidase activity was observed only in neoplastic conditions. Serum oxidase activity can fall to very low levels in the advanced cirrhosis and may disappear almost entirely in the patients in hepatic coma. This progressive reduction in oxidase activity might be expression of the failure of the synthetic functions of the liver, which occurs in severe liver disease. The finding of a low level of ceruloplasmin does not in any case seem to be particular to Wilson's disease. No changes in the electrophoretic mobility of the enzyme have been observed in any of the pathological cases studied.

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mentioning

confidence: 99%

Ceruloplasmin Activity in Liver Diseases Quantitative Determination and Electrophoretic Characterization

Gc¹,

Petrella²,

Lomanto³

et al. 1967

Enzymol Biol Clin

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The Behaviour of Ceruloplasmin Fractions in Liver Diseases

Trip

Botterweg-Span

et al. 1969

Journal of Internal Medicine

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Abstract. Ceruloplasmin fractions I(C‐C) and II(C‐D) have been estimated in patients with infectious hepatitis, liver metastases and cirrhosis of the liver. In infectious hepatitis and metastases serum ceruloplasmin content was increased and the percentage of fraction I(C‐C) was decreased; no correlation between these parameters could be found. In the group of cirrhotics mean serum ceruloplasmin concentration was normal but the mean percentage of fraction I(C‐C) was decreased. A positive correlation between these values could be demonstrated. Very low ceruloplasmin levels were found in some patients with the most severe form of liver cirrhosis; if this is the result of an impaired synthesis, it seems probable that especially fraction I(C‐C) is affected by this disturbance. The possibility that only fraction I(C‐C) is synthesized by the liver is discussed.

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Ceruloplasmin im Serum der Leberzirrhosen

Cited by 2 publications

References 1 publication

Ceruloplasmin Activity in Liver Diseases Quantitative Determination and Electrophoretic Characterization

Ceruloplasmin Activity in Liver Diseases Quantitative Determination and Electrophoretic Characterization

The Behaviour of Ceruloplasmin Fractions in Liver Diseases

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