Ceruloplasmin and Copper Level in Maternal and Cord Blood and in the Placenta in Normal Pregnancy and in Pre‐Eclampsia

Fattah, Mohamed M. A.; Ibrahim, Fawzia K.; Ramadan, M.; Sammour, Mohamed B.

doi:10.3109/00016347609158520

Cited by 39 publications

(12 citation statements)

References 7 publications

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“…11,12 Although published studies demonstrate that serum iron [13][14][15] and copper 16 levels are elevated in preeclampsia, studies comparing these parameters in mild and severe preeclampsia are limited. [17][18][19] A number of studies have reported that blood 16,[20][21][22][23][24] and placental [25][26][27] levels of lipid peroxidation products are also elevated in women with preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

Serum iron and copper status and oxidative stress in severe and mild preeclampsia

Serdar

Gür

Develíoğlu

2006

Cell Biochem. Funct.

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Our aim was to investigate parameters of iron and copper status and oxidative stress and antioxidant function in women with healthy pregnancy, mild and severe preeclampsia with a view to exploring the possible contribution of these parameters to the aetiology. Thirty healthy, 30 mild preeclamptic and 30 severe preeclamptic pregnant women were included. Serum and placental lipid peroxides, and serum vitamin E and total carotene levels were measured by colorimetric assay. Cholesterol, copper, iron, total iron binding capacity (TIBC), ceruloplasmin and transferrin concentrations were measured by commercially available procedures. Data were analysed statistically using one-way analysis of variance and Pearson correlation test. Logistic regression procedures were used to calculate odds ratios. Lipid peroxides in serum and placental tissue, and iron, copper and ceruloplasmin levels in serum were significantly increased, and transferrin, TIBC, vitamin E/total cholesterol and total carotene/total cholesterol ratios in serum were significantly decreased especially in women with severe preeclampsia. Significant correlations were detected between serum iron and lipid peroxides in serum and placental tissue and between serum iron and vitamin E/total cholesterol in severe preeclamptic pregnancy. Furthermore, there were significant correlations between serum malondialdehyde and ceruloplasmin and vitamin E/total cholesterol in women with severe preeclampsia, and changes in serum and placental lipid peroxides and serum iron concentrations were significantly associated with preeclampsia. In conclusion, ischaemic placental tissue may be a primary source of potentially toxic iron in preeclampsia and the released iron species may contribute to the aetiology and would exacerbate lipid peroxidation and endothelial cell injury, which may be abated by antioxidant supplementation.

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Section: Introductionmentioning

confidence: 99%

Serum iron and copper status and oxidative stress in severe and mild preeclampsia

Serdar

Gür

Develíoğlu

2006

Cell Biochem. Funct.

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“…The level of ceruloplasmin has been shown to be lower in fetal blood than in maternal blood, while the level of nonceruloplasmin Cu is the same (9). This implies that ceruloplasmin does not cross the placenta from mother to child, and the presence of ceruloplasmin in cord blood is therefore a result of fetal synthesis.…”

Section: Discussionmentioning

confidence: 75%

Abnormal Copper Metabolism in Menke's Steely-Hair Syndrome

et al. 1979

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SummaryCopper (Cu) metabolism was selectively studied in seven infants with Menke's steely-hair syndrome (SHS). A daily oral regimen of CuS04 (584 pg Cu/kg) and L-histidine (100 mg/kg) in three infants produced an increase in serum Cu concentrations ranging from 33-95% of normal, but without the formation of ceruloplasmin. Cohn serum protein fractionation after oral CU/L-histidine loading showed a disproportionate accumulation of Cu in the albumin fraction (V). The electron spin resonance spectrum of fraction V showed a heightened signal for the S H S patients, suggesting that an increased concentration of a radical Cu species is present after oral loading. The Sephadex G-150 chromatographic profile of serum fraction V in SHS did not differ significantly from controls. These results suggest that, in SHS, Cu absorbed in the presence of L-histidine is in an abnormal complex involving albumin, which does not allow for holoceruloplasmin biosynthesis. Cu and ceruloplasmin concentrations in the cord blood specimen of an infant who went on to develop SHS were normal, a finding which may account for the transient period of seemingly normal development after birth in SHS patients. An almost &fold difference in mean Cu concentration was observed in SHS fibroblasts compared to controls. Fibroblast Cu concentration was elevated in one of two possible maternal heterozygotes, a finding which may permit diagnosis of the carrier state for some SHS heterozygotes. SpeculationThe basic defect in SHS may be an abnormality in an intracellular Cu binding or transport protein, which is present in multiple tissues. This suggestion is supported by data from intestine and skin fibroblasts and may, in part, explain the common failure of simple Cu replenishment to alter the clinical course of SHS.In 1972, Danks et al. (3) demonstrated a deficiency in the intestinal absorption of Cu in SHS and suggested that a general dysfunction in Cu containing enzymes might account for the keratin and collagen abnormalities, cerebrovascular disease, scorbutic bone changes, and hypothermia commonly seen in the disorder. Although Cu deficiency, as reflected by the low levels of serum Cu and ceruloplasmin, has been found to be a universal feature of the disease, emerging evidence suggests that defective intestinal absorption of the metal may be only part of a more widespread disorder of Cu transport and/or binding. Danks et al. (3) found that erythrocyte Cu concentrations were normal in four SHS infants, suggesting a preferential retention of Cu by red blood cells. Elevated Cu concentrations have also been demonstrated in liver (5, 16), skin fibroblasts (4, 14), amniotic fluid cells (19), and small intestine (2, 3) in the disorder. Excessive urinary (1 1) and fecal (6) excretion of Cu has been reported in SHS, along with unresponsiveness of Cu metalloenzymes (12). Replenishment of Cu deficiency through parenteral supplementation has not yielded impressive clinical results. At best, there is a mild subjective improvement (2, 3, 6) or a partial arrest of sy...

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“…However, there is some evidence that either lower or higher levels of ceruloplasmin compared to levels observed during normal pregnancy could be an indication of problems associated with gestation in humans. Abnormal levels of ceruloplasmin have been found in blood and/or in amniotic fluid during pregnancies which resulted in such conditions as spontaneous abortions, preeclampsia, and Klinefelter's syndrome [30], [31], [32], [33], [34].…”

Section: Discussionmentioning

confidence: 99%

The Acute Phase Protein Ceruloplasmin as a Non-Invasive Marker of Pseudopregnancy, Pregnancy, and Pregnancy Loss in the Giant Panda

et al. 2011

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After ovulation, non-pregnant female giant pandas experience pseudopregnancy. During pseudopregnancy, non-pregnant females exhibit physiological and behavioral changes similar to pregnancy. Monitoring hormonal patterns that are usually different in pregnant mammals are not effective at determining pregnancy status in many animals that undergo pseudopregnancy, including the giant panda. Therefore, a physiological test to distinguish between pregnancy and pseudopregnancy in pandas has eluded scientists for decades. We examined other potential markers of pregnancy and found that activity of the acute phase protein ceruloplasmin increases in urine of giant pandas in response to pregnancy. Results indicate that in term pregnancies, levels of active urinary ceruloplasmin were elevated the first week of pregnancy and remain elevated until 20–24 days prior to parturition, while no increase was observed during the luteal phase in known pseudopregnancies. Active ceruloplasmin also increased during ultrasound-confirmed lost pregnancies; however, the pattern was different compared to term pregnancies, particularly during the late luteal phase. In four out of the five additional reproductive cycles included in the current study where females were bred but no birth occurred, active ceruloplasmin in urine increased during the luteal phase. Similar to the known lost pregnancies, the temporal pattern of change in urinary ceruloplasmin during the luteal phase deviated from the term pregnancies suggesting that these cycles may have also been lost pregnancies. Among giant pandas in captivity, it has been presumed that there is a high rate of pregnancy loss and our results are the first to provide evidence supporting this notion.

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Ceruloplasmin and Copper Level in Maternal and Cord Blood and in the Placenta in Normal Pregnancy and in Pre‐Eclampsia

Cited by 39 publications

References 7 publications

Serum iron and copper status and oxidative stress in severe and mild preeclampsia

Serum iron and copper status and oxidative stress in severe and mild preeclampsia

Abnormal Copper Metabolism in Menke's Steely-Hair Syndrome

The Acute Phase Protein Ceruloplasmin as a Non-Invasive Marker of Pseudopregnancy, Pregnancy, and Pregnancy Loss in the Giant Panda

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