Certification of a 41Ca dose material for use in human studies (IRMM-3703) and a corresponding set of isotope reference materials for 41Ca measurements (IRMM-3701)

Hennessy, Carmel; Berglund, Michael; Ostermann, Markus; Walczyk, Thomas; Synal, Hans-Arno; Geppert, Christopher; Wendt, Κ.; Taylor, Philip

doi:10.1016/j.nimb.2004.11.021

Cited by 22 publications

(45 citation statements)

References 12 publications

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“…Several review articles have addressed the applications and limitations of ICP-MS for the determination of radionuclides [2][3][4][5][6][7][8][9]. Because of the high sensitivity, short analysis time and relatively easy operation, ICP-MS has been widely used for the determination of isotopes of uranium, thorium, and plutonium, 79 Se, 90 Sr, 99 Tc, 129 I, 135 Cs, 210 Pb, 226 Ra, 228 Ra, 231 Pa, 237 Np, 241 Am, 243 Am, and 244 Cm in environmental and waste samples .…”

Section: Inductively Coupled Plasma Mass Spectrometry (Icp-ms)mentioning

confidence: 99%

“…These inherent effects limiting the capability of isotope ratio measurements by TIMS can be considered by different internal calibration techniques or by using isotopic standard reference materials with well-known isotopic ratios for an element. Besides, U, Th and Pu, TIMS has also been used for many other radionuclides, such as 41 Ca, 241 Am, 242 Cm, 126 Sn, 226 Ra, 228 Ra [82,[90][91][92][93].…”

Section: Thermal Ionization Mass Spectrometry (Tims)mentioning

confidence: 99%

“…RIMS as a highly selective and sensitive mass spectrometric technique for ultratrace and isotope analysis has been used for the analysis of many radionuclides such as 41 Ca, 90 Sr, 99 Tc, 135 Cs, 210 Pb, 236 U, 238 Pu, 239 Pu, 240 Pu, 242 Pu, and 244 Pu in environmental, biological and waste samples [33,34,[94][95][96][97][98][99][100][101][102][103][104][105]. In RIMS the solid or liquid samples are vaporized and atomized by an atomic beam source (e.g.…”

Section: Resonance Ionization Mass Spectrometry (Rims)mentioning

confidence: 99%

“…However, due to the poor energy resolution of LSC and the low energy Auger electron spectrum of 41 Ca, calcium has to be completely separated from the matrix and all other radionuclides before counting. Hou [19] reported a chemical procedure for the separation of calcium from concrete based on the precipitation of Ca(OH) 2 in high concentration of NaOH (> 0.5 mol/L) with a decontamination factor higher than 10 4 for most interfering radionuclides, such as 133 Ba, 90 Sr, 60 Co, and 152 Eu. A detection limit of 0.1 Bq was reported using LSC [19].…”

Section: Calcium-41mentioning

confidence: 99%

“…90 Sr is one of important radionuclides in the views of radiation protection, environmental monitoring, radioecology, and radioactive waste management due to its relative high radioactive level in environmental and nuclear waste samples. The interest in the determination of 90 Sr and 89 Sr comes also from utilization of them as environmental tracers (Table 1).…”

Section: Stronium-89 90mentioning

confidence: 99%

See 4 more Smart Citations

Critical comparison of radiometric and mass spectrometric methods for the determination of radionuclides in environmental, biological and nuclear waste samples

Hou

Roos

2008

Analytica Chimica Acta

339

253

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Section: Inductively Coupled Plasma Mass Spectrometry (Icp-ms)mentioning

confidence: 99%

Section: Thermal Ionization Mass Spectrometry (Tims)mentioning

confidence: 99%

Section: Resonance Ionization Mass Spectrometry (Rims)mentioning

confidence: 99%

Section: Calcium-41mentioning

confidence: 99%

Section: Stronium-89 90mentioning

confidence: 99%

See 3 more Smart Citations

Critical comparison of radiometric and mass spectrometric methods for the determination of radionuclides in environmental, biological and nuclear waste samples

Hou

Roos

2008

Analytica Chimica Acta

339

253

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Labeling the human skeleton with 41Ca to assess changes in bone calcium metabolism

et al. 2006

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Bone research is limited by the methods available for detecting changes in bone metabolism. While dual X-ray absorptiometry is rather insensitive, biochemical markers are subject to significant intra-individual variation. In the study presented here, we evaluated the isotopic labeling of bone using 41Ca, a long-lived radiotracer, as an alternative approach. After successful labeling of the skeleton, changes in the systematics of urinary 41Ca excretion are expected to directly reflect changes in bone Ca metabolism. A minute amount of 41Ca (100 nCi) was administered orally to 22 postmenopausal women. Kinetics of tracer excretion were assessed by monitoring changes in urinary 41Ca/40Ca isotope ratios up to 700 days post-dosing using accelerator mass spectrometry and resonance ionization mass spectrometry. Isotopic labeling of the skeleton was evaluated by two different approaches: (i) urinary 41Ca data were fitted to an established function consisting of an exponential term and a power law term for each individual; (ii) 41Ca data were analyzed by population pharmacokinetic (NONMEM) analysis to identify a compartmental model that describes urinary 41Ca tracer kinetics. A linear three-compartment model with a central compartment and two sequential peripheral compartments was found to best fit the 41Ca data. Fits based on the use of the combined exponential/power law function describing urinary tracer excretion showed substantially higher deviations between predicted and measured values than fits based on the compartmental modeling approach. By establishing the urinary 41Ca excretion pattern using data points up to day 500 and extrapolating these curves up to day 700, it was found that the calculated 41Ca/40Ca isotope ratios in urine were significantly lower than the observed 41Ca/40Ca isotope ratios for both techniques. Compartmental analysis can overcome this limitation. By identifying relative changes in transfer rates between compartments in response to an intervention, inaccuracies in the underlying model cancel out. Changes in tracer distribution between compartments were modeled based on identified kinetic parameters. While changes in bone formation and resorption can, in principle, be assessed by monitoring urinary 41Ca excretion over the first few weeks post-dosing, assessment of an intervention effect is more reliable approximately 150 days post-dosing when excreted tracer originates mainly from bone.

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Determination of 41Ca with LSC and AMS: method development, modifications and applications

Hampe¹,

Gleisberg²,

Akhmadaliev

et al. 2012

J Radioanal Nucl Chem

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Certification of a 41Ca dose material for use in human studies (IRMM-3703) and a corresponding set of isotope reference materials for 41Ca measurements (IRMM-3701)

Cited by 22 publications

References 12 publications

Critical comparison of radiometric and mass spectrometric methods for the determination of radionuclides in environmental, biological and nuclear waste samples

Critical comparison of radiometric and mass spectrometric methods for the determination of radionuclides in environmental, biological and nuclear waste samples

Labeling the human skeleton with 41Ca to assess changes in bone calcium metabolism

Determination of 41Ca with LSC and AMS: method development, modifications and applications

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