Certain Parameters of the Hemostasis System, as Well as Indicators of Tryptophane Metabolism in Patients With Coronary Heart Disease

Abstract

The hemostasis system is a functional system of the human body that ensures the integrity and patency of the vessels of the circulatory system, prevents or stops bleeding, and also maintains the blood in a liquid state. The functioning of the hemostasis system is based on a balanced interaction between its coagulation, anticoagulation and fibrinolytic links. According to modern concepts, destabilization of hemovascular homeostasis is one of the main mechanisms of progression of coronary heart disease (CHD). Biologically active substances of endogenous origin can play the role of triggers of cardiovascular events, along with generally accepted factors such as obesity, arterial hypertension, diabetes and smoking. Establishing the nature of genesis factors and mechanisms of progression of cardiovascular symptoms will increase the probability of a positive prognosis for patients with coronary heart disease, which remains the most common cause of mortality in the population of developed countries. The purpose of this study was to find out the level of some biologically active substances, including certain factors of the coagulation cascade and the fibrinolysis system, parameters of tryptophan metabolism and heat shock proteins (namely, HPS 60 and HPS 70), in patients with coronary artery disease. 66 patients diagnosed with coronary artery disease took part in the study: 20 of them had a confirmed diagnosis of stable angina, 28 had progressive unstable angina, and 18 had myocardial infarction. The results of the study showed an increased production of prothrombotic mediators (Willebrand factor, serotonin) in the blood plasma of patients with coronary artery disease. An imbalance between tissue plasminogen activator and its inhibitor was also noted, which may be the main factor in reducing the fibrinolytic potential of blood plasma under cardiovascular events. It has been established that patients with coronary heart disease, regardless of the form of the disease, are characterized by a significant increase in the plasma content of heat shock protein, namely HPS 60. Such results suggest the possible involvement of this protein in the pathological reactions that occur during coronary heart disease, and the possibility of its use as a biomarker of cardiovascular diseases.