ceRNA Network Analysis Shows That lncRNA CRNDE Promotes Progression of Glioblastoma Through Sponge mir-9-5p

Luo, Xiaobin; Tu, Tianqi; Zhong, Yali; Xu, Shangyi; Chen, Xiangzhou; Chen, Ligang; Yang, Fubing

doi:10.3389/fgene.2021.617350

Cited by 21 publications

(11 citation statements)

References 56 publications

(62 reference statements)

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“…Wang et al reported that the glioma cells growth and invasion was promoted by over-expression of lncRNA CRNDE, and the lncRNA CRNDE positively correlates with EGFR activation [21]. Luo et al found that lncRNA CRNDE promoted glioblastoma progression through sponge to mir-9-5p [22]. Shi et al reported that lncRNA-CRNDE promoted BMSC chondrogenic differentiation and cartilage repair through SIRT1/SOX9 [23].…”

Section: Discussionmentioning

confidence: 99%

LncRNA CRNDE Promoted Colorectal Cancer Cells Reisitance To Paclitaxel Through Wnt/β-Catenin Signaling Pathway

Tang

et al. 2021

Preprint

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Background The lncRNA colorectal neoplasia differentially expressed (lncRNA CRNDE) is commonly over-expressed in different human cancers and involved in different biological functions. Paclitaxel(PTX) is a tricyclic diterpenoid compound which often used as a natural anticancer drugs in cancer treatments. Although there have many research reports about the mechanisms of LncRNA involved in PTX treatment, there are no any research about lncRNA CRNDE and PTX resistance in colorectal cancer. The purpose of this study is to investigate the mechanisims of LncRNA CRNDE involving PTX resistance in colorectal cancer. Results We constructed lncRNA CRNDE over-expression vector and transfected it into SW620 cell. CCK8, Transwell experiments proved that over-expression of lnc CRNDE increased SW620 cells proliferation and invasion, while the si-CRNDE group was significantly decreased. over-expression CRNDE can significantly up-regulate β-catenin, c-myc, APC and Axin2 expression and affect the expression of cyclinD1 and CDK4 after treated with PTX. Conclusion lncRNA CRNDE promotes CRCs proliferation, invasion and migration. Over-expression of LncRNA CRNDE enhanced the reisitance of CRC to PTX through inhibition of Wnt/ β-catenin signaling pathway.

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Section: Discussionmentioning

confidence: 99%

LncRNA CRNDE Promoted Colorectal Cancer Cells Reisitance To Paclitaxel Through Wnt/β-Catenin Signaling Pathway

Tang

et al. 2021

Preprint

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“…ceRNA can bind to miRNAs through miRNA response elements (MREs) to affect miRNA-induced gene silencing. Recent studies have shown that ceRNA is an important mechanism for the occurrence and development of various CNS disorders ( Moreno-García et al, 2020 ; Luo et al, 2021 ). Interaction with target sites in the mRNA 3′ UTR can lead to reduced mRNA stability and translational repression, thereby regulating RNA gene expression ( Amort et al, 2013 ).…”

Section: Mechanisms Of Hotair Functionmentioning

confidence: 99%

Long Non-coding RNA HOTAIR in Central Nervous System Disorders: New Insights in Pathogenesis, Diagnosis, and Therapeutic Potential

Wang

Zhao

Pan

et al. 2022

Front. Mol. Neurosci.

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Central nervous system (CNS) disorders, such as ischemic stroke, neurodegenerative diseases, multiple sclerosis, traumatic brain injury, and corresponding neuropathological changes, often lead to death or long-term disability. Long non-coding RNA (lncRNA) is a class of non-coding RNA with a transcription length over 200 nt and transcriptional regulation. lncRNA is extensively involved in physiological and pathological processes through epigenetic, transcription, and post-transcriptional regulation. Further, dysregulated lncRNA is closely related to the occurrence and development of human diseases, including CNS disorders. HOX Transcript antisense RNA (HOTAIR) is the first discovered lncRNA with trans-transcriptional regulation. Recent studies have shown that HOTAIR may participate in the regulation of the occurrence and development of CNS disorders. In addition, HOTAIR has the potential to become a new biomarker for the diagnosis and prognosis assessment of CNS disorders and even provide a new therapeutic target for CNS disorders. Here, we reviewed the research results of HOTAIR in CNS disorders to provide new insights into the pathogenesis, diagnostic value, and therapeutic target potential of HOTAIR in human CNS disorders.

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“…To do this, we predicted the possible miRNA binding sites on the lncRNA sequences and determine their normalized binding free energy (ndG) based on the complementary base pairing, using LncTar 19 . Furthermore, miRNA, lncRNA, their target genes, and the biological processes were connected on a critical network using Cytoscape version 3.7.2, as described previously 54,65 .…”

Section: Prediction Of Lncrna-mirna Interactions Associated With Bovine Mastitis Pathogenesismentioning

confidence: 99%

Regulatory Network of miRNA, lncRNA, Transcription Factor and Target Immune Response Genes in Bovine Mastitis

Morenikeji

Tucker

Salazar

et al. 2021

Preprint

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Pre- and post-transcriptional modifications of gene expression are emerging as foci of disease studies, with some studies revealing the importance of non-coding transcripts, like long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). We hypothesize that TFs, lncRNAs and miRNAs can modulate the immune response in bovine mastitis and potentially serve as disease biomarkers and/or drug targets. With computational analyses, we identified candidate genes potentially regulated by miRNAs and lncRNAs base pair complementation and thermodynamic stability of binding regions. Remarkably, we found six miRNAs, two being bta-miR-223 and bta-miR-24-3p, to bind to several targets. NONBTAT027932.1 and XR_003029725.1, were identified to target several genes. Functional and pathway analyses revealed lipopolysaccharide-mediated signaling pathway, regulation of chemokine (C-X-C motif) ligand 2 production and regulation of IL-23 production among others. The overarching interactome deserves further in vitro/in vivo explication for specific molecular regulatory mechanisms during bovine mastitis immune response and could lay the foundation for development of disease markers and therapeutic intervention.

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ceRNA Network Analysis Shows That lncRNA CRNDE Promotes Progression of Glioblastoma Through Sponge mir-9-5p

Cited by 21 publications

References 56 publications

LncRNA CRNDE Promoted Colorectal Cancer Cells Reisitance To Paclitaxel Through Wnt/β-Catenin Signaling Pathway

LncRNA CRNDE Promoted Colorectal Cancer Cells Reisitance To Paclitaxel Through Wnt/β-Catenin Signaling Pathway

Long Non-coding RNA HOTAIR in Central Nervous System Disorders: New Insights in Pathogenesis, Diagnosis, and Therapeutic Potential

Regulatory Network of miRNA, lncRNA, Transcription Factor and Target Immune Response Genes in Bovine Mastitis

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