Cerivastatin (BAY w 6228): A Novel HMG‐CoA Reductase Inhibitor

The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping

“…However, cell death driven by mepazine was further augmented upon SREBP2 silencing (Figure S2B). Similar results were obtained with cerivastatin-induced inhibition of HMGCR, the rate-limiting enzyme in the cholesterol biosynthetic pathway 60 (Figure S2C). Autophagy obstruction, as illustrated with the accumulation of P62 and LC3B lipidated forms, was also exacerbated when both MALT1 and SREBP2 were hampered (Figure S2D-E).…”

“…Our results, therefore, suggest that MALT1-inhibited GSCs execute a program to compensate for the retention of cholesterol in lysosomes. In a MALT1-negative context, hampering SREBP2-induced cholesterol synthesis with RNA interference or cerivastatin, an inhibitor of the rate-limiting enzyme of the cholesterol biosynthesis pathway 60 , aggravates both autophagy defects and cell death in GSCs. Thus, this suggests a strong dependency of these cells toward finely maintained cholesterol homeostasis.…”

Dynamic pathway allocation in early terpenoid biosynthesis of stress-induced lima bean leaves

“…To block the MEP-pathway, fosmidomycin (Okuhara et al, 1980), an inhibitor of the DXP-reducto isomerase (Jomaa et al, 1999) was used. Cerivastatin Ò served as an efficient inhibitor of the HMG-CoA reductase (Kuhlmann et al, 1998) of the MVA-pathway (see Scheme 1).…”

Zuordnung von Terpenen zur Methylerythritolphosphat- oder zur Mevalonat-Route anhand der natürlichen12C/13C-Isotopenverhältnisse: dynamische Ressourcennutzung in induzierten Pflanzen

“…Demnach sollte sich der δ ( 13 C)‐Wert für DMNT (Abbildung 2) verschieben lassen, wenn einer der beiden Wege selektiv blockiert wird. Dazu wurden Bohnentriebe vor der Duftinduktion mit Cerivastatin 7 ,20 einem äußerst wirksamen Inhibitor der MVA‐Route behandelt. Die MEP‐Route wurde mit Fosmidomycin 8 inhibiert, das die DXP‐Reduktoisomerase blockiert (Schema ) 21.…”