Cerium tissue/organ distribution and alterations in open field and exploratory behavior following repeated exposure of the mouse to citrate complexed cerium

Morganti, John B.; Lown, Bradley A.; Stineman, Carl H.; Massaro, Edward J.

doi:10.1016/0306-3623(78)90045-9

Cited by 9 publications

(3 citation statements)

References 9 publications

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“…Inaba and Yasumoto (93) reported that 4% of applied CeCl3 was absorbed from the stripped guinea pig's skin while 89% of CsCl and 79% of CoCl2 were absorbed from the skin under the same experimental conditions. It has been shown that Ce3+ was deposited in the liver, spleen, and bone following subcutaneous (sc) injection of Ce3+-citrate (95,96). Intramuscularly injected CeCI3 has been reported to accumulate in the lysosomes of the liver in rats and hamsters (97).…”

mentioning

confidence: 99%

Exposure, metabolism, and toxicity of rare earths and related compounds.

Hirano

Suzuki

1996

Environ Health Perspect

336

116

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For the past three decades, most attention in heavy metal toxicology has been paid to cadmium, mercury, lead, chromium, nickel, vanadium, and tin because these metals widely polluted the environment. However, with the development of new materials in the last decade, the need for toxicological studies on those new materials has been increasing. A group of rare earths (RE) is a good example. Although some RE have been used for superconductors, plastic magnets, and ceramics, few toxicological data are available compared to other heavy metals described above. Because chemical properties of RE are very similar, it is plausible that their binding affinities to biomolecules, metabolism, and toxicity in the living system are also very similar. In this report, we present an overview of the metabolism and health hazards of RE and related compounds, including our recent studies.ImagesFigure 1. AFigure 1. BFigure 1. C

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mentioning

confidence: 99%

Exposure, metabolism, and toxicity of rare earths and related compounds.

Hirano

Suzuki

1996

Environ Health Perspect

336

116

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“…The low risk associated with the oral administration of cerium species is supported by their low absorption, with more than 95% of the species being excreted in the faeces [ 9 , 40 ]. Moreover, orally administered lanthanide compounds at low doses have even been reported to have beneficial effects for laboratory and farm animals [ 9 , 41 ] resulting in a significant increase in their immune level [ 9 ].…”

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confidence: 99%

The Strong Protective Action of Ce3+/F− Combined Treatment on Tooth Enamel and Epithelial Cells

et al. 2022

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We studied the toxic effects of cerium and fluoride species on human dental pulp stem cells and epithelial cells of Cercopithecus aethiops as a surrogate for the human oral mucosa. The sequential use of CeCl3 and NH4F solutions in equimolar sub-toxic concentrations enabled the possible toxic effects of individual components to be avoided, ensuring the preservation of the metabolic activity of the cells due to the formation of CeF3 nanoparticles. Cerium fluoride nanoparticles and terbium-doped cerium fluoride nanoparticles exhibited neither cytotoxicity nor genotoxicity to dental pulp stem cells, even at high concentrations (10−4 M). In millimolar concentrations (from 10−5–10−6 M), these nanoparticles significantly increased the expression of genes responsible for the cell cycle, differentiation and proliferation. The formation of cerium fluoride on the surface of the mucous membrane and teeth provided protection against the development of carious lesions, periodontitis, ROS attacks and other inflammatory diseases of the oral cavity. Luminescent CeF3: Tb nanoparticles enabled the visualization of tooth enamel microcracks.

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“…Intratesticular injection of REEs caused degeneration of the seminiferous epithelium and the interstitium (Kamboj and Kar, 1964). Subcutaneous administration of Ce 3+ revealed that the testes are one of the main targeted organs for REE deposition (Morganti et al, 1978). Our previous study also indicated that the testes are one of the targeted organs of samarium (Sm) administrated orally in male mice.…”

Section: Introductionmentioning

confidence: 91%

Effect of acute/subchronic samarium exposure on the concentration, motility, and morphology of sperm in male mice

Zhang

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Male ICR mice were orally administered samarium nitrate [Sm(NO 3 ) 3 ] to investigate its effects on sperm concentration and sperm quality. After acute exposure to ≥2880.00 mg/kg Sm(NO 3 ) 3 via intragastric gavage, sperm motility and acrosome integrity were decreased, and the sperm malformation percentage was increased (P < 0.05). After subchronic exposure to ≥500.00 mg/L Sm(NO 3 ) 3 administered via drinking water for 90 days, relative gonad weight, sperm concentration, and sperm quality significantly decreased (P < 0.05). Sperm malformation also increased after subchronic exposure to Sm, which was found to be the most sensitive index. Sperm head malformation accounted for the largest proportion of all types of sperm malformations evaluated. Of the six different subtypes of head malformation, irregular shape accounted for the largest proportion.

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Cerium tissue/organ distribution and alterations in open field and exploratory behavior following repeated exposure of the mouse to citrate complexed cerium

Cited by 9 publications

References 9 publications

Exposure, metabolism, and toxicity of rare earths and related compounds.

Exposure, metabolism, and toxicity of rare earths and related compounds.

The Strong Protective Action of Ce3+/F− Combined Treatment on Tooth Enamel and Epithelial Cells

Effect of acute/subchronic samarium exposure on the concentration, motility, and morphology of sperm in male mice

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