Cerium (IV) Ammonium Nitrate (CAN) Catalyzed One-pot Synthesis of 2-Arylbenzothiazoles

Al-Qalaf, Fawzia; Mekheimer, Ramadan Ahmed; Sadek, Kamal Usef

doi:10.3390/molecules13112908

Cited by 45 publications

(22 citation statements)

References 27 publications

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“…We have initiated a program aimed at exploring the potential of CAN in organic transformation. This effort led to the development of a onepot CAN-catalyzed synthesis of 2-arylthiazoloes 116 from the reaction of 2-aminothiophenol 115 and aromatic aldehydes (Scheme 26 and Table 18) [82].…”

Section: Solvent-free Reactionsmentioning

confidence: 99%

Green methodologies in organic synthesis: recent developments in our laboratories

Hafez

Al‐Mousawi

Moustafa

et al. 2013

Green Chemistry Letters and Reviews

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The results of the studies carried out in our laboratories during the last 15 years, aimed at developing green methodologies for the synthesis of polyfunctionalized heteroaromatic substances, are surveyed. The results of the investigations demonstrate that green methodologies are not only less hazard than classical preparative methods but they also are more efficient and economical. For example, short reaction times and higher yields are observed for reactions in which conventional heating is replaced by microwave or ultrasound irradiation. The implementation of multicomponent reactions in green preparative routes also reduces the cost of carrying out the reactions because multiple separation and crystallization steps are avoided. In general, by employing the new green methodologies we have been able to produce a large number of polyfunctional aromatic substances in a highly efficient manner.

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Section: Solvent-free Reactionsmentioning

confidence: 99%

Green methodologies in organic synthesis: recent developments in our laboratories

Hafez

Al‐Mousawi

Moustafa

et al. 2013

Green Chemistry Letters and Reviews

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“…The cyclocondensation of aryl aldehydes and 2-aminothiophenol have been performed by Itoh et al (46) using scandium triflate and obtained better yields of the benzothiazoles. Al-Qalaf et al (47) have reported the cyclization of 2-aminothiophenols and aldehydes using ceric ammonium nitrate as an oxidant in methanol and obtained moderate yields of the benzothiazoles.…”

Section: *Corresponding Author Email: Manera@indiatimescommentioning

confidence: 99%

An efficient green protocol for the synthesis of 2-aryl substituted benzothiazoles

Mali

Jawale

Londhe

et al. 2010

Green Chemistry Letters and Reviews

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“…The reaction of equimolar amounts of 1 (2-aminothiophenol) and 2 (aromatic aldehydes) in methanol (MeOH) in the presence of CAN resulted into corresponding 2-arylbenzothiazoles 4 in good yields (75-89%) via the intermediate formation of schiff's bases 3 [44].…”

Section: Reaction Of 2-aminothiophenol and Aromatic Aldehydesmentioning

confidence: 99%

Practical Approach to Green Chemistry

Bhandari

Raj

2017

Int J Pharm Pharm Sci

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The basic principles of green chemistry addresses various issues related to synthesis of chemical compounds: planning organic synthesis to maximise yield, prevention/minimization of waste, atom economy, the use of less lethal chemicals, use of safer solvents, renewable starting materials, energy efficiency and use of green catalysts. The objective of this study is to elaborate the practical approach of green methods. In this paper, we elucidate some important common syntheses having green procedures which can be used in the fields of pharmaceutical chemistry and other fields as well. Green chemistry principles follow up to reduce pollution and environmental degradation by utilizing eco-friendly, nonhazardous, reproducible and efficient solvents and catalysts in the synthesis of drug molecules, drug intermediates and in researches involving synthetic chemistry. The paper also approaches green methods in which microwave radiation can be used as an energy efficient tool. Experimental procedures are gathered from educational journals and laboratory manuals and are viewed in the light of efficacy of green chemistry principles.

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Cerium (IV) Ammonium Nitrate (CAN) Catalyzed One-pot Synthesis of 2-Arylbenzothiazoles

Abstract: A one-pot synthesis of 2-arylbenzothiazoles from the reaction of 2-amino-thiophenol and aromatic aldehydes catalysed by cerium (IV) ammonium nitrate (CAN) is reported.

Cited by 45 publications

References 27 publications

Green methodologies in organic synthesis: recent developments in our laboratories

Green methodologies in organic synthesis: recent developments in our laboratories

An efficient green protocol for the synthesis of 2-aryl substituted benzothiazoles

Practical Approach to Green Chemistry

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