Cerium-induced strain-dependent increase in Cyp2a-45 (cytochrome P4502a-45) expression in the liver and kidneys of inbred mice

Salonpää, Pirkko; İşcan, Mümtaz; Pasanen, Markku; Arvela, P.; Pelkonen, Olavi; Raunio, Hannu

doi:10.1016/0006-2952(92)90525-n

Cited by 28 publications

(13 citation statements)

References 21 publications

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“…Pyrazole induces via mRNA stabilization [41] whereas phenobarbital increases transcription [43]. Renal Cyp2a5 is induced in mice following cerium chloride [38] or pyrazole [41] treatment, but to our knowledge this is the first time As 3+ administration has been shown to cause this response (Figures 3 and 6).…”

Section: Discussionmentioning

confidence: 80%

“…Cyp2a5 is unique in its regulation because several structurally unrelated compounds are known to induce it. For example, phenobarbital, pyrazole, carbon tetrachloride (CCl 4 ), metals such as cerium chloride and hepatic inflammation caused by hepatitis B virus induce Cyp2a5 expression in liver of mice [37][38][39][40]. In addition, the upregulation of Cyp2a5 by xenobiotics often occurs when total CYP content decreases and HO-1 activity increases, as occurs following CCl 4 treatment [6,37] or As 3+ treatment in mouse kidney ( Figure 3).…”

Section: Discussionmentioning

confidence: 99%

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Acute sodium arsenite treatment induces Cyp2a5 but not Cyp1a1 in the C57Bl/6 mouse in a tissue (kidney) selective manner

Seubert¹,

Webb²,

Bend³

2002

J Biochem & Molecular Tox

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Modulation of hepatic and extrahepatic detoxication enzymes Cyp1a1, Cyp2a5, glutathione Stransferse Ya (GSTYa) and NAD(P)H:quinone oxidoreductase (QOR) dependent catalytic activity and mRNA levels were investigated at 1, 2, or 4 days in liver, lung, or kidney of male, adult CD57 Bl/6 mice treated sc with a single dose (85 mol/kg) of sodium arsenite (As 3+ ). Maximum decreases of total hepatic cytochrome P450 (CYP) monooxygenase content and catalytic activities, occurring at 24 h, corresponded with maximum increases of heme oxygenase (HO-1) in all tissues, as well as maximum plasma total bilirubin. Extrahepatic increases in CYP were observed only in non-AHR dependent isozymes in the kidney, where both Cyp2a5 mRNA and catalytic activity increased maximally 24 h after treatment. In contrast, no significant changes in Cyp2b1/2-dependent PROD or mRNA activity and decreases in Cyp1a1-dependent-EROD activity were noted 1, 2, or 4 days after treatment. Increases in QOR catalytic activities were observed in all tissues examined with increased mRNA in kidney. On the other hand, GSTYa catalytic activity and mRNA increases were only detected in kidney. This study demonstrates the differential modulation of CYP, QOR, and GSTYa, important drug metabolizing enzymes after acute As 3+ administration. The induction of Cyp2a5, QOR, and GSTYa catalytic activity and gene expression occurred primarily in kidney during or shortly after conditions of oxidant stress. C

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Acute sodium arsenite treatment induces Cyp2a5 but not Cyp1a1 in the C57Bl/6 mouse in a tissue (kidney) selective manner

Seubert¹,

Webb²,

Bend³

2002

J Biochem & Molecular Tox

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“…However, the reason that fatty liver was limited to female rats that received CeCI3 remained unknown. It seems that iv injection of CeCl3 produces lipid droplets in the liver of male mice (109).…”

Section: Exposure To Rare Earthsmentioning

confidence: 99%

“…Intravenously injected RE chlorides increase vascular permeability for low molecular weight substances (108) and cause necrosis in the liver (109). Subcutaneous administration of Ce(NO3)3 has also been found to cause hepatic necrosis (96).…”

Section: Exposure To Rare Earthsmentioning

confidence: 99%

“…Otherwise, the biochemical changes are consistent among RE; those biochemical changes are increase in triglyceride in the liver (105,110,113,117) and increases in leakage of hepatic enzymes into blood (46,105,(111)(112)(113)(114)(115)(116). RE-induced hepatic injury seems to reduce P450 content and P450-related enzyme activities in rat (113) and mouse (109,119); however, the decreases in P450 activities (coumarin 7-hydroxylase and 7-ethoxyresorufin O-deethylase) at 3 to 4 days after iv injection of CeCI3 were preceded by increases in these enzyme activities at 1 to 2 days postinjection in DBA/2 mice (109,119). Serum very low density lipoprotein (VLDL) and high density lipoprotein (HDL) have been shown to be decreased following iv injection of Pr(NO3)3 in rats; the decrease is probably due to a decrease in hepatic secretion of these lipoproteins (118).…”

Section: Exposure To Rare Earthsmentioning

confidence: 99%

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Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

Hirano¹,

Suzuki²

1996

Environmental Health Perspectives

152

187

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The Lanthanides, Rare Earth Elements

Darby

2023

Patty's Toxicology

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The lanthanides, known also as lanthanoids or rare earth elements (REEs), consist of 17 elements with remarkable properties that have made them emerge in the twenty‐first century as a highly‐valued commodity by the world's industrialized nations. REEs form the largest chemically coherent group in the periodic table. China has led the world production of REEs for decades. The diverse applications of REEs for national defense, energy production and storage, high‐strength magnets, lasers, and medical diagnostics and therapeutics, combined with China's restrictions on supply beginning in 2010, have led to a near‐crisis consisting of national stockpiling, frantic exploration for new deposits, and intense efforts to conserve, recycle and substitute for REEs. The unique physical, chemical and magnetic properties of REEs become particularly interesting at the nanoparticle size, leading to an explosion of research in the last two decades. For these reasons, the commercial and academic pressure to explore new applications of REEs risks outpacing essential research on the toxicology of REEs.

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Cerium-induced strain-dependent increase in Cyp2a-45 (cytochrome P4502a-45) expression in the liver and kidneys of inbred mice

Cited by 28 publications

References 21 publications

Acute sodium arsenite treatment induces Cyp2a5 but not Cyp1a1 in the C57Bl/6 mouse in a tissue (kidney) selective manner

Acute sodium arsenite treatment induces Cyp2a5 but not Cyp1a1 in the C57Bl/6 mouse in a tissue (kidney) selective manner

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

The Lanthanides, Rare Earth Elements

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