Cerium doping and stoichiometry control for biomedical use of La0.7Sr0.3MnO3 nanoparticles: microwave absorption and cytotoxicity study

Kale, S. N.; Arora, Sumit; Bhayani, Kavita R.; Paknikar, Kishore M.; Jani, Mona; Wagh, U. V.; Kulkarni, S.D.; Ogale, S. B.

doi:10.1016/j.nano.2006.10.001

Cited by 35 publications

(15 citation statements)

References 20 publications

(11 reference statements)

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“…13,14 LSMO nanoparticles were then coated with dextran sulfate sodium salt to improve biocompatibility as reported earlier.…”

Section: Materials and Methods Synthesis And Characterization Of Dex-mentioning

confidence: 99%

“…We have earlier reported that dextran-coated La 0.7 Sr 0.3 MnO 3 (Dex-LSMO) nanoparticles (30-50 nm) with Curie temperature of ~360 K (~86°C) show self-controlled heating property and have potential to be used for both localized hyperthermia 13,14 and magnetic resonance imaging (MRI). 15 Although iron oxide nanoparticles (magnetite/maghemite) are extensively studied for hyperthermia, the heating is not self-controlled in the therapeutic range owing to their high Curie temperature.…”

Section: Haghniaz Et Almentioning

confidence: 99%

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Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

Haghniaz

Umrani

Paknikar

2016

IJN

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Purpose The aim of this study was to evaluate radiofrequency-induced dextran-coated lanthanum strontium manganese oxide nanoparticles-mediated hyperthermia to be used for tumor regression in mice. Materials and methods Nanoparticles were injected intra-tumorally in melanoma-bearing C57BL/6J mice and were subjected to radiofrequency treatment. Results Hyperthermia treatment significantly inhibited tumor growth (~84%), increased survival (~50%), and reduced tumor proliferation in mice. Histopathological examination demonstrated immense cell death in treated tumors. DNA fragmentation, increased terminal deoxynucleotidyl transferase-dUTP nick end labeling signal, and elevated levels of caspase-3 and caspase-6 suggested apoptotic cell death. Enhanced catalase activity suggested reactive oxygen species-mediated cell death. Enhanced expression of heat shock proteins 70 and 90 in treated tumors suggested the possible development of “antitumor immunity”. Conclusion The dextran-coated lanthanum strontium manganese oxide-mediated hyperthermia can be used for the treatment of cancer.

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“…13,14 LSMO nanoparticles were then coated with dextran sulfate sodium salt to improve biocompatibility as reported earlier.…”

Section: Materials and Methods Synthesis And Characterization Of Dex-mentioning

confidence: 99%

Section: Haghniaz Et Almentioning

confidence: 99%

Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

Haghniaz

Umrani

Paknikar

2016

IJN

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“…21 These dextran-coated (Dex)-LSMO nanoparticles were found to display a low Curie temperature (360 K) and self-controlled heating properties on exposure to RF. 22,23 To evaluate the efficacy of hyperthermia mediated by Dex-LSMO nanoparticles, we selected murine melanoma (B16F1) cells as a cancer model, since this cancer is reported to be resistant to conventional treatment such as chemotherapy. 24 Before treatment with hyperthermia, it was important to confirm that the Dex-LSMO nanoparticles themselves do not damage cells.…”

Section: Introductionmentioning

confidence: 99%

Temperature-dependent and time-dependent effects of hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3: in vitro studies

Haghniaz¹,

Umrani²,

Paknikar³

2015

IJN

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Background The purpose of this study was to investigate the therapeutic efficacy of dextran-coated (Dex) La 0.7 Sr 0.3 MnO 3 (LSMO) nanoparticles-mediated hyperthermia at different temperatures (43°C, 45°C, and 47°C) based on cell killing potential and induction of heat shock proteins in a murine melanoma cell (B16F1) line. Methods LSMO nanoparticles were synthesized by a citrate-gel method and coated with dextran. B16F1 cells were exposed to the Dex-LSMO nanoparticles and heated using a radiofrequency generator. After heating, the morphology and topology of the cells were investigated by optical microscopy and atomic force microscopy. At 0 hours and 24 hours post heating, cells were harvested and viability was analyzed by the Trypan blue dye exclusion method. Apoptosis and DNA fragmentation were assessed by terminal deoxynucleotidyl transferase-dUTP nick end labeling (TUNEL) assay and agarose gel electrophoresis, respectively. An enzyme-linked immunosorbent assay was used to quantify heat shock protein levels. Results Our data indicate that cell death and induction of heat shock proteins in melanoma cells increased in a time-dependent and temperature-dependent manner, particularly at temperatures higher than 43°C. The mode of cell death was found to be apoptotic, as evident by DNA fragmentation and TUNEL signal. A minimum temperature of 45°C was required to irreversibly alter cell morphology, significantly reduce cell viability, and result in 98% apoptosis. Repeated cycles of hyperthermia could induce higher levels of heat shock proteins (more favorable for antitumor activity) when compared with a single cycle. Conclusion Our findings indicate a potential use for Dex-LSMO-mediated hyperthermia in the treatment of melanoma and other types of cancer.

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“…Thus, if the Curie temperature can be fixed by judicious selection of particle composition and size, hyperthermia can be applied and carefully controlled 61 However, along with the increasing interest in treatment of cancer using an effective patient friendly approach like hyperthermia there is also a rising concern with use of the conventional hyperthermia agents-iron oxide nanoparticle. Iron oxide nanoparticles generally show high Curie temperature 34 ; and additionally add to iron homeostasis and toxicity concerns 68 Thus advantage of 'self-controlled' heating in desirable range can establish LSMO nanoparticles as superior hyperthermia mediator in comparison to its counterparts 62,69 .…”

Section: Lsmo Nanoparticles For Magnetic Fluid Hyperthermiamentioning

confidence: 99%

Lanthanum strontium manganese oxide (LSMO) nanoparticles: a versatile platform for anticancer therapy

2015

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Lanthanum Strontium Manganese oxide (LSMO) nanoparticles are a new class of magnetic nanoparticles, which exhibit favorable magnetic and biological properties for therapy using hyperthermia, imaging and diagnosis; opening avenues for multimodal anti-cancer therapy. Ease of synthesis and facile surface modifications makes LSMO nanoparticles a promising candidate for its application in anti-cancer therapy.

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Cerium doping and stoichiometry control for biomedical use of La0.7Sr0.3MnO3 nanoparticles: microwave absorption and cytotoxicity study

Cited by 35 publications

References 20 publications

Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

Temperature-dependent and time-dependent effects of hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3: in vitro studies

Lanthanum strontium manganese oxide (LSMO) nanoparticles: a versatile platform for anticancer therapy

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