Cerimetric Determination of Four Antihypertensive Drugs in Pharmaceutical Preparations

El‐Didamony, Akram M.; Erfan, Eman

doi:10.4067/s0717-97072011000400011

Cited by 8 publications

(5 citation statements)

References 75 publications

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“…CAS because of its high oxidation potential and excellent solution stability has been widely used as an effective analytical reagent in spectrophotometric methods for the determination of many pharmaceutical compounds [27][28][29][30][31]. The analytical reactions involved two steps; the first one was concerned with oxidation of TOL with a known excess of CAS in acidic medium at room temperature (25°C±2°C).…”

Section: Resultsmentioning

confidence: 99%

Sensitive Spectrophotometric Assay of Muscarinic Receptor Antagonist Tolterodine Tartrate in Bulk Drug and Pharmaceutical Formulations

El-Sheikh

Hаssаn

Gouda

et al. 2017

Asian J Pharm Clin Res

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Objective: Simple, sensitive, and accurate spectrophotometric methods have been developed for the assay of tolterodine tartrate (TOL) in bulk drug and pharmaceutical formulations. Methods:The proposed methods are based on oxidation reaction of TOL with a known excess of cerium(IV) ammonium sulfate as an oxidizing agent in acid medium followed by determination of unreacted oxidant by adding a fixed amount of dye, e.g., amaranth (AM), rhodamine 6G (Rh6G), and indigo carmine (IC) followed by measuring the absorbance at 520, 530, and 610 nm, respectively. The effect of experimental conditions was studied and optimized.Results: The Beer's law was obeyed in the concentration ranges of 1.0-10, 1.0-12, and 0.5-9.0 μg/mL using AM, Rh6G, and IC dyes, respectively, with a correlation coefficient ≥0.9995. The calculated molar absorptivity values are 1.868×10 4 , 1.008×10 4 , and 1.623×104 L/mol/cm using AM, Rh6G, and IC dyes, respectively. The limits of detection and quantification were reported. Intraday and interday accuracy and precision of the methods have been evaluated. No interference was observed from the additives. Conclusion:The proposed methods were successfully applied to the assay of TOL in tablets preparations, and the results were statistically compared with those of the reported method by applying Student's t-test and F-test. The reliability of the methods was further ascertained by performing recovery studies using the standard addition method.

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Section: Resultsmentioning

confidence: 99%

Sensitive Spectrophotometric Assay of Muscarinic Receptor Antagonist Tolterodine Tartrate in Bulk Drug and Pharmaceutical Formulations

El-Sheikh

Hаssаn

Gouda

et al. 2017

Asian J Pharm Clin Res

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“…It is necessary to develop analytical methods for the determination of drug in commercial dosage forms because of the great use of drug. Several analytical methods have been reported which are based on the bromination reaction of ATN with a known excess of bromate-bromide mixture in acid medium [5,6] or based on the oxidation of the ATN by a known excess of cerric (IV) in acid medium [7], or titration of the drug in glacial acetic acid with acetous perchloric acid to the visual end point using crystal violet as indicator [8]. UV spectrophotometric methods with sensitive titrimetric used for determination of ATN in tablet formulations [9].…”

Section: Scheme 1: Chemical Structur Of Atenololmentioning

confidence: 99%

Spectrophotometric Determination of Atenolol Using Indigo Carmine Dye

Saleem¹

2019

KUJSS

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A simple, rapid, accurate and precise spectrophotometric method is proposed for the determination of atenolol in both pure form and in its pharmaceutical formulation. The method is based on the oxidation of atenolol with chromate in acidic medium of 1N H 2 SO 4 , the residual amount of oxidizing agent is then reacted with indigo carmine dye in the presence of oxalate as a catalyst, the increase in the absorbance of the dye, which is proportional to the amount of the determinants atenolol is then measured at 610 nm. Beer's law is obeyed in the concentration range of 30-1500 µg/25 ml with a molar absorptivity of 0.73×10 4 l.mol-1 .cm-1 , Sandell's sensitivity index of 0.364 μg.cm-2 , and a relative standard deviation of ± 0.263 to ± 0.376% depending on the concentration level. The limit of detection (LOD) and limit of quantification (LOQ) are 0.3259 and 1.0863 μg ml −1 , respectively. The proposed method has been applied successfully to the determination of atenolol in pure and pharmaceutical preparation.

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“…The techniques are sensitive but expensive and require laborious preparation prior to analysis. Spectrophotometry is inherently simple and frequently used in the laboratories of developing countries in preference to complicated analytical procedures [15][16][17][18][19][20][21][22][23][24]. Amoxicillin (AMX), (Fig.…”

Section: Introductionmentioning

confidence: 99%

Direct and indirect spectrophotometric determination of some selected antibiotics using potassium permanganate

El‐Didamony

Saad

El-Shaprawy

2013

Main Group Chemistry

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Two spectrophotometric methods were developed for the quantitative determination of Cefoperazone (CFP) and Amoxicillin (AMX) in pure forms as well as their active pharmaceutical ingredients (API). The methods are based on a redox reaction between the selected drugs and KMnO 4 in alkaline or acid media. Direct spectrophotometry (method A) involves treating the aqueous solution of the selected drugs with KMnO 4 in alkaline medium and measuring the bluish-green product at 610 nm. In indirect spectrophotometry (method B), the drug solutions were treated with a fixed concentration of KMnO 4 in acidic medium followed by the determination of the unreacted oxidant by measuring the decrease in absorbance of methylene blue at 665 nm. The different experimental parameters affecting the development and stability of the color were carefully studied and optimized. Beer's law is obeyed over 2.0-40 (method A) and 0.8-7.2 g/mL (method B). The molar absorptivity, Sandell sensitivity, detection and quantification limits were also calculated. The intra-and inter-day relative standard deviation (RSD) values demonstrated the validity of the two methods for the drugs in pure form and as the API. Statistical comparison of the results with a well-established official method showed excellent agreement and proved that there is no significant difference in the accuracy and precision.

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Cerimetric Determination of Four Antihypertensive Drugs in Pharmaceutical Preparations

Cited by 8 publications

References 75 publications

Sensitive Spectrophotometric Assay of Muscarinic Receptor Antagonist Tolterodine Tartrate in Bulk Drug and Pharmaceutical Formulations

Sensitive Spectrophotometric Assay of Muscarinic Receptor Antagonist Tolterodine Tartrate in Bulk Drug and Pharmaceutical Formulations

Spectrophotometric Determination of Atenolol Using Indigo Carmine Dye

Direct and indirect spectrophotometric determination of some selected antibiotics using potassium permanganate

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