Ceria Nanoparticle Systems Alleviate Degenerative Changes in Mouse Postovulatory Aging Oocytes by Reducing Oxidative Stress and Improving Mitochondrial Functions
Danmei Zhang,
Lingcun Ji,
Yiran Yang
et al.
Abstract:Postovulatory aging oocytes usually feature diminished
potential
for fertilization and poor embryonic development due to enhanced oxidative
damage to the subcellular organelles and macromolecules, which stands
as a formidable obstacle in assisted reproductive technologies (ART).
Here, we developed lipoic acid (LA) and polyethylene glycol (PEG)-modified
CeO2 nanoparticles (LA-PEG-CeNPs) with biocompatibility,
enzyme-like autocatalytic activity, and free radical scavenging capacity.
We further investigated the L… Show more
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