Cerenkov radiation-activated probes for deep cancer theranostics: a review

Liu, Nian; X, Su; Sun, Xiaolian

doi:10.7150/thno.75279

Cited by 7 publications

(3 citation statements)

References 105 publications

(146 reference statements)

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“…Furthermore, radiation can indirectly generate ROS or hydrated electrons in tumors, resulting in the breakage of ROS-activatable linkers or quaternary ammonium masking groups 59 . Notably, the unlimited penetration capacity of radiation allows for enhancing photodynamic therapy, fluorescence imaging, and X-ray-excited persistent luminescence for deeply-seated tumors 60 .…”

Section: Stimuli-activatable Strategies For Nanomedicine-assisted Can...mentioning

confidence: 99%

Stimuli-activatable nanomedicine meets cancer theranostics

Li,

Feng,

Luo

et al. 2023

Theranostics

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Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics. Upon exposure to endogenous/exogenous stimuli, the stimuli-activatable nanomedicine could be self-assembled, disassembled, or functionally activated to improve its biosafety and diagnostic/therapeutic potency. A myriad of tumor-specific features, including a low pH, a high redox level, and overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, and radiation) have been considered for the design of stimuli-activatable nano-medicinal products. Recently, novel stimuli sources have been explored and elegant designs emerged for stimuli-activatable nanomedicine. In addition, multi-functional theranostic nanomedicine has been employed for imaging-guided or image-assisted antitumor therapy. In this review, we rationalize the development of theranostic nanomedicine for clinical pressing needs. Stimuli-activatable self-assembly, disassembly or functional activation approaches for developing theranostic nanomedicine to realize a better diagnostic/therapeutic efficacy are elaborated and state-of-the-art advances in their structural designs are detailed. A reflection, clinical status, and future perspectives in the stimuli-activatable nanomedicine are provided.

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Section: Stimuli-activatable Strategies For Nanomedicine-assisted Can...mentioning

confidence: 99%

Stimuli-activatable nanomedicine meets cancer theranostics

Li,

Feng,

Luo

et al. 2023

Theranostics

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“…A recent advanced approach to overcome the tissue penetration limitation of light was to use Cerenkov radiation (CR) as internal light instead of external light to activate the photosensitizers. − CR occurs when the charged particles travel faster than the speed of light in the medium, emitting continuous wavelength light which is mainly concentrated in the ultraviolet to blue light region . Many medical radionuclides (e.g., 18 F, 68 Ga, 64 Cu, 89 Zr, and 131 I) could serve as CR emitters and recent studies have developed several nanoplatforms integrated radionuclide and photosensitizer in a spatiotemporal manner to achieve high-efficient PDT. − After intravenous injection of nanoparticles, a small fraction can reach tumor tissues during long blood circulation, accompanied by short retention, limited treatment effectiveness of PDT, and the undesirable distribution of radionuclides in normal organs that may also have toxic side effects .…”

Section: Introductionmentioning

confidence: 99%

Self-Illuminating In Situ Hydrogel with Immune-Adjuvant Amplify Cerenkov Radiation-Induced Photodynamic Therapy

Zhang,

Guo,

Zhou

et al. 2023

Chemical & Biomedical Imaging

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Cerenkov radiation-induced photodynamic therapy (CR-induced PDT) has shown the potential to overcome the light penetration limitation in conventional PDT. In addition, the tumor-associated antigens (TAAs) produced by PDT can initiate an antitumor immune process but only show a limited immunotherapeutic effect without the use of immunotherapeutic agents. Herein, a CR-induced PDT hydrogel (R837/89Zr-HG-PpIX) has been developed by in situ formation of a hyaluronic acid (HA)-based hydrogel integrated with internal light source 89Zr, photosensitizer protoporphyrin IX (PpIX), and immune adjuvant imiquimod (R837). The obtained R837/89Zr-HG-PpIX hydrogel with long-term tumor retention and low radiation leakage can provide long-lasting photodynamic therapy without phototoxicity in normal tissues. In addition, the loaded R837 improves the immunogenicity of TAAs released after PDT, resulting in considerably enhanced immune responses. At relatively low radioactivity, R837/89Zr-HG-PpIX shows significant inhibition in subcutaneous H22 tumor-bearing BALB/c mice and orthotopic VX2 liver tumor-bearing rabbits. Furthermore, the combination of such a CR-induced PDT hydrogel with anti-PD-L1 exhibits the abscopal effect to inhibit the growth of distant tumors. Therefore, the proposed in situ formed CR-induced PDT hydrogel with long-term photodynamic-immunotherapy provides an effective strategy for deep tumor therapy.

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“…8 Since tissue autofluorescence only has 1–10 ns of decay lifetime, while SiNCs feature bright long-lived (more than microseconds) luminescence, time-gated imaging technology is employed to suppress the short-lived autofluorescence of tissues, 9,10 but the above two methods are less effective for deep tissues because of the rapid attenuation of light as it passes through tissue. 11 Therefore, it is worthwhile to develop a new excitation source for SiNC activation.…”

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confidence: 99%