Cerenkov Luminescence-Induced NO Release from 32P-Labeled ZnFe(CN)5NO Nanosheets to Enhance Radioisotope-Immunotherapy

Tian, Longlong; Wang, Yaxing; Sun, Lele; Xu, Jun; Chao, Yu; Yang, Kai; Wang, Shuao; Liu, Zhuang

doi:10.1016/j.matt.2019.07.007

Cited by 78 publications

(49 citation statements)

References 54 publications

(60 reference statements)

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“…JC-1 is a specific fluorescent probe of mitochondrial membrane potential that reflects the state of mitochondria by displaying two different fluorescent colors, red and green. 55 Hence we further determined the change of mitochondrial membrane potential (DJ m ) of A375 cells after various treatments by using a JC-1 probe. As indicated from the results ( Figure S38), GTe-RGD and X-ray irradiation groups downregulated the DJ m of A375 cells to a more significant level than other groups, in accordance with the results of fluorescence images by MitoTracker probe ( Figure 3F).…”

Section: Radiosensitization Efficacy Of Gte-rgd On X-raysmentioning

confidence: 99%

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Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint Blockade Immunotherapy

Huang

Ouyang

et al. 2020

Matter

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Section: Radiosensitization Efficacy Of Gte-rgd On X-raysmentioning

confidence: 99%

“…After treatment of GTe-RGD and GTe for 4 h and X-ray irradiation, these cells were collected, resuspended in PBS solution, and stained with JC-1 (10 mg/mL) for 30 min, followed by flow-cytometry analysis. 55…”

Section: Article Experimental Proceduresmentioning

confidence: 99%

Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint Blockade Immunotherapy

Huang

Ouyang

et al. 2020

Matter

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“…In addition, Zn-pyrophosphate (ZnP) nanoparticles, 32 P-Labeled ZnFe(CN) 5 NO nanosheets,l ayered double hydroxide,c alcium phosphate composites,a nd Prussian blue are currently in development for cancer immunotherapy. [80]…”

Section: Kurzaufsätzementioning

confidence: 99%

Improving Cancer Immunotherapy Outcomes Using Biomaterials

Yan

Luo

et al. 2020

Angewandte Chemie

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Immunotherapy has made great strides in improving clinical outcomes in cancer treatment. However, few patients exhibit adequate response rates for key outcome measures and desired long‐term responses, and they often suffer systemic side effects due to the dynamic nature of the immune system. This has motivated a search for alternative strategies to improve unsatisfactory immunotherapeutic outcomes. In recent years, biomaterial‐assisted immunotherapy has shown promise in cancer treatment with improved therapeutic efficacy and reduced side effects. These biomaterials have illuminated fundamental mechanisms underlying the immunoediting process, while greatly improving the efficacy of chimeric antigen receptor (CAR) T‐cell therapy, cancer vaccine therapy, and immune checkpoint blockade therapy. This Minireview discusses recent advances in engineered biomaterials that address limitations associated with conventional cancer immunotherapies.

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“…However, NO cannot circulate in body with high concentration (half-life is less than 5 s and diffusion radius is less than 40 µm) and it can participate in many pathways to disturb internal environment due to their high bioactivity [13,17,[22][23][24][25][26][27]. A potential strategy to develop a system for controlled and precisely release of NO to hypoxic tumors during radiotherapy holds great promise to improve the RT [7,16,[28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy

et al. 2020

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HIGHLIGHTS • Ag 2 S NO delivery platforms maximize radiotherapy effects remarkably to inhibit the tumor growth. • Immunosuppressive tumor microenvironment was improved by Ag 2 S NO delivery system, significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy. ABSTRACT Radiotherapy (RT) is a widely used way for cancer treatment. However, the efficiency of RT may come with various challenges such as low specificity, limitation by resistance, high dose and so on. Nitric oxide (NO) is known a very effective radiosensitizer of hypoxic tumor. However, NO cannot circulate in body with high concentration. Herein, an NIR light-responsive NO delivery system is developed for controlled and precisely release of NO to hypoxic tumors during radiotherapy. Tert-Butyl nitrite, which is an efficient NO source, is coupled to Ag 2 S quantum dots (QDs). NO could be generated and released from the Ag 2 S QDs effectively under the NIR irradiation due to the thermal effect. In addition, Ag is also a type of heavy metal that can benefit the RT therapy. We demonstrate that Ag 2 S NO delivery platforms remarkably maximize radiotherapy effects to inhibit tumor growth in CT26 tumor model. Furthermore, immunosuppressive tumor microenvironment is improved by our NO delivery system, significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy. 100% survival rate is achieved by the radio-immune combined therapy strategy based on the Ag 2 S NO delivery platforms. Our results suggest the promise of Ag 2 S NO delivery platforms for multifunctional cancer radioimmunotherapy.

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Cerenkov Luminescence-Induced NO Release from 32P-Labeled ZnFe(CN)5NO Nanosheets to Enhance Radioisotope-Immunotherapy

Cited by 78 publications

References 54 publications

Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint Blockade Immunotherapy

Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint Blockade Immunotherapy

Improving Cancer Immunotherapy Outcomes Using Biomaterials

Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy

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