Cerebrovascular Surgery: Past, Present, and Future

Heros, Roberto C.; Morcos, Jacques J.

doi:10.1097/00006123-200011000-00001

Cited by 56 publications

(17 citation statements)

References 237 publications

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“…1,2 The etiology and patho-genesis of CV have not been identified yet, despite the existing wide investigations, and therefore no medically effective treatment method has been found. 4,5 Although many drugs known as antioxidants have been used both in vivo and in vitro for the prevention of CV, we have not found any investigation for the prevention of CV with zinc by increasing the SOD activity. Zinc is bound to superoxide dismutase (SOD) and is responsible for the activity of this enzyme.…”

mentioning

confidence: 83%

Morphometric Analysis of the Influence of Zinc on the Vasospastic Femoral Artery in Rats

Günaldı

Çöllüoğlu

Tuğcu

et al. 2015

Neurosurgery Quarterly

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Aim: Cerebral vasospasm is one of the most prominent causes of morbidity and mortality after subarachnoid hemorrhage. It is well known that free radicals and lipid peroxidation exist among the theories of vasoconstriction in the etiopathogenesis of cerebral vasospasm. Zinc is responsible for the activity of superoxide dismutase enzyme and may prevent or minimize the vasoconstriction that is caused by free oxygen radicals. Many studies have been conducted with antioxidant agents, but we have not found any investigation for the prevention of cerebral vasospasm with zinc by increasing the enzyme activity.Materials and Methods: Rats were divided into 3 groups: group 1 (n = 8, control group), group 2 (n = 8, vasospasm group), and group 3 (n = 8, vasospasm+ZnCl 2 group). Lumen diameter and thickness of vessel wall were compared histopathologically.Results: In the statistical comparison of groups 1 and 2, significant thickening in the vessel wall and decrease in the diameter of lumen were determined in group 2 (P < 0.05). Although no difference between the 2 groups were determined in the statistical comparison of diameter of the vessel lumen in groups 1 and 3, the thickness of the vessel wall was thicker in group 3 (P < 0.05). The diameter of the vessel lumen was wider in group 3 in the statistical comparison of groups 2 and 3 (P < 0.05), and the vessel wall was observed as thickened in group 2.Conclusions: All of these findings show us in the preliminary study that the vasospasm after subarachnoid hemorrhage may be inhibited by the use of zinc.

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confidence: 83%

Morphometric Analysis of the Influence of Zinc on the Vasospastic Femoral Artery in Rats

Günaldı

Çöllüoğlu

Tuğcu

et al. 2015

Neurosurgery Quarterly

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“…3,11 Second Period in Berlin In 1856 Virchow returned to Berlin to become director of the Pathological Institute, where he trained a new generation of pathologists. In 1863, in his monumental three-volume treatise on blood vessels, Virchow also recognized and differentiated almost all of the common types of intracranial malformations: telangiectatic venous malformations, arterial malformations, arteriovenous malformations, and cystic angiomas (possibly what are now called hemangioblastomas).…”

Section: It Has Been Shown Experimentally By [Francois] Magendie [1mentioning

confidence: 99%

Rudolf Ludwig Karl Virchow: pathologist, physician, anthropologist, and politician

Safavi–Abbasi

Reis

Talley

et al. 2006

FOC

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✓ The history of apoplexy and descriptions of stroke symptoms date back to ancient times. It was not until the mid-nineteenth century, however, that the contributions of Rudolf Ludwig Karl Virchow, including his descriptions of the phenomena he called “embolism” and “thrombosis” as well as the origins of ischemia, changed the understanding of stroke. He suggested three main factors that conduce to venous thrombosis, which are now known as the Virchow triad. He also showed that portions of what he called a “thrombus” could detach and form an “embolus.” Thus, Virchow coined these terms to describe the pathogenesis of the disorder. It was also not until 1863 that Virchow recognized and differentiated almost all of the common types of intracranial malformations: telangiectatic venous malformations, arterial malformations, arteriovenous malformations, cystic angiomas (possibly what are now called hemangioblastomas), and transitional types of these lesions. This article is a review of the contributions of Rudolf Virchow to the current understanding of cerebrovascular pathology, and a summary of the life of this extraordinary personality in his many roles as physician, pathologist, anthropologist, ethnologist, and politician.

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“…9) However, surgical resection of a cerebral AVM often represents one of the most technically challenging procedures for neurosurgeons. Morbidity and mortality rates of microsurgical resection of AVM vary from 7.8-30% and 0-12.5%, respectively.…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Magnetic Resonance Imaging Based on Time-of-Flight Magnetic Resonance Angiography for Superficial Cerebral Arteriovenous Malformation -Technical Note-

Murata

Horiuchi

Rahmah

et al. 2011

Neurol. Med. Chir.(Tokyo)

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Direct surgery remains important for the treatment of superficial cerebral arteriovenous malformation (AVM). Surgical planning on the basis of careful analysis from various neuroimaging modalities can aid in resection of superficial AVM with favorable outcome. Three-dimensional (3D) magnetic resonance (MR) imaging reconstructed from time-of-flight (TOF) MR angiography was developed as an adjunctive tool for surgical planning of superficial AVM. 3-T TOF MR imaging without contrast medium was performed preoperatively in patients with superficial AVM. The images were imported into OsiriX imaging software and the 3D reconstructed MR image was produced using the volume rendering method. This 3D MR image could clearly visualize the surface angioarchitecture of the AVM with the surrounding brain on a single image, and clarified feeding arteries including draining veins and the relationship with sulci or fissures surrounding the nidus. 3D MR image of the whole AVM angioarchitecture was also displayed by skeletonization of the surrounding brain. Preoperative 3D MR image corresponded to the intraoperative view. Feeders on the brain surface were easily confirmed and obliterated during surgery, with the aid of the 3D MR images. 3D MR imaging for surgical planning of superficial AVM is simple and noninvasive to perform, enhances intraoperative orientation, and is helpful for successful resection.

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Cerebrovascular Surgery: Past, Present, and Future

Cited by 56 publications

References 237 publications

Morphometric Analysis of the Influence of Zinc on the Vasospastic Femoral Artery in Rats

Morphometric Analysis of the Influence of Zinc on the Vasospastic Femoral Artery in Rats

Rudolf Ludwig Karl Virchow: pathologist, physician, anthropologist, and politician

Three-Dimensional Magnetic Resonance Imaging Based on Time-of-Flight Magnetic Resonance Angiography for Superficial Cerebral Arteriovenous Malformation -Technical Note-

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