Cerebrovascular Reactivity Measurement with Functional Near Infrared Spectroscopy

Amyot, Franck; Davis, Cora; Sangobowale, Mike; Moore, Carol; Silverman, Erika; Gandjbakhche, Amir; Kenney, Kimbra

doi:10.3791/61284

Cited by 2 publications

(3 citation statements)

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“…Transcranial doppler (TCD) ultrasound, near infrared spectroscopy (NIRS) can also be used as non-invasive and indirect measures of CBF regulation and CVR ( Ainslie and Duffin, 2009 ; Amyot et al, 2022 ). TCD measures blood velocities within an artery, often the middle cerebral artery, as a proxy for CBF.…”

Section: Characterising Vascular Smooth Muscle Cell Dysfunction ...mentioning

confidence: 99%

Vascular smooth muscle cell dysfunction in neurodegeneration

Hayes

Pinto²,

Sparks³

et al. 2022

Front. Neurosci.

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Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics in response to the brain’s oxygen and nutrient demands. Crucially, VSMCs may provide a sensitive biomarker for neurodegenerative pathologies where vasculature is compromised. An increasing body of research suggests that VSMCs have remarkable plasticity and their pathophysiology may play a key role in the complex process of neurodegeneration. Furthermore, extrinsic risk factors, including environmental conditions and traumatic events can impact vascular function through changes in VSMC morphology. VSMC dysfunction can be characterised at the molecular level both preclinically, and clinically ex vivo. However the identification of VSMC dysfunction in living individuals is important to understand changes in vascular function at the onset and progression of neurological disorders such as dementia, Alzheimer’s disease, and Parkinson’s disease. A promising technique to identify changes in the state of cerebral smooth muscle is cerebrovascular reactivity (CVR) which reflects the intrinsic dynamic response of blood vessels in the brain to vasoactive stimuli in order to modulate regional cerebral blood flow (CBF). In this work, we review the role of VSMCs in the most common neurodegenerative disorders and identify physiological systems that may contribute to VSMC dysfunction. The evidence collected here identifies VSMC dysfunction as a strong candidate for novel therapeutics to combat the development and progression of neurodegeneration, and highlights the need for more research on the role of VSMCs and cerebrovascular dynamics in healthy and diseased states.

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Section: Characterising Vascular Smooth Muscle Cell Dysfunction ...mentioning

confidence: 99%

Vascular smooth muscle cell dysfunction in neurodegeneration

Hayes

Pinto²,

Sparks³

et al. 2022

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Despite its lower spatial resolution, it has a higher temporal resolution than fMRI ( Ferrari & Quaresima, 2012 ), up to 100 Hz, which offers an advantage in better characterizing the delays in CVR ( Amyot et al, 2020 ; MacIntosh et al, 2003 ). fNIRS has been previously used to quantify CVR in both breath-holding and gas inhalation settings ( Amyot et al, 2020 , 2022 ; Karunakaran et al, 2021 ; S. Miller & Mitra, 2021 ; Reddy et al, 2021 ; Smielewski et al, 1995 ; Vagné et al, 2020 ). Wilson and colleagues measured CVR in 6 individuals with tetraplegia using both transcranial doppler and fNIRS, and reported similar CVR in response to CO2 in tetraplegia and able-bodied control groups, suggesting cerebrovascular adaptation with chronic tetraplegia ( Wilson et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Delayed cerebrovascular reactivity in individuals with spinal cord injury in the right inferior parietal lobe: a breath-hold functional near-infrared spectroscopy study

Chen,

Di,

Karunakaran

et al. 2024

Preprint

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Cerebrovascular reactivity (CVR) reflects the ability of blood vessels to dilate or constrict in response to a vasoactive stimulus, and allows researchers to assess the brain’s vascular health. Individuals with spinal cord injury (SCI) are at an increased risk for autonomic dysfunction in addition to cognitive impairments, which have been linked to a decline in CVR; however, there is currently a lack of brain-imaging studies that investigate how CVR is altered after SCI. In this study, we used a breath-holding hypercapnic stimulus and functional near-infrared spectroscopy (fNIRS) to investigate CVR alterations in individuals with SCI (n = 20, 14M, 6F, mean age = 46.3 ± 10.2 years) as compared to age– and sex-matched able-bodied (AB) controls (n = 25, 19M, 6F, mean age = 43.2 ± 12.28 years). CVR was evaluated by its amplitude and delay components separately by using principal component analysis and cross-correlation analysis, respectively. We observed significantly delayed CVR in the right inferior parietal lobe in individuals with SCI compared to AB controls (linear mixed-effects model, fixed-effects estimate = 6.565, Satterthwaite’s t-test, t = 2.663, p = 0.008), while the amplitude of CVR was not significantly different. The average CVR delay in the SCI group in the right inferior parietal lobe was 14.21 s (sd: 6.60 s), and for the AB group, the average delay in the right inferior parietal lobe was 7.08 s (sd: 7.39 s). CVR delays were also associated with the duration since injury in individuals with SCI, in which a longer duration since injury was associated with a shortened delay in CVR in the right inferior parietal region (Pearson’s r-correlation, r = –0.59, p = 0.04). This study shows that fNIRS can be used to quantify changes in CVR in individuals with SCI, and may be further used in rehabilitative settings to monitor the cerebrovascular health of individuals with SCI.

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Cerebrovascular Reactivity Measurement with Functional Near Infrared Spectroscopy

Cited by 2 publications

References 0 publications

Vascular smooth muscle cell dysfunction in neurodegeneration

Vascular smooth muscle cell dysfunction in neurodegeneration

Delayed cerebrovascular reactivity in individuals with spinal cord injury in the right inferior parietal lobe: a breath-hold functional near-infrared spectroscopy study

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