Cerebrovascular Reactivity Is Not Associated With Therapeutic Intensity in Adult Traumatic Brain Injury: A Validation Study

Froese, Logan; Gomez, Alwyn; Sainbhi, Amanjyot Singh; Vakitbilir, Nuray; Marquez, Izzy; Amenta, Fiorella; Park, K.; Stein, Kevin Y.; Thelin, Eric Peter; Zeiler, Frederick A.

doi:10.1089/neur.2023.0011

Cited by 1 publication

(1 citation statement)

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“…Impaired CA is common in TBI patients [ 51 , 52 ]; as such, the versatility of the artifact identification method was contingent upon its functionality in patients with impaired and intact CA, which necessitated sub-group analyses for CA state. Cerebral oxygenation index (CO x _a) was used as a metric to quantify cerebral autoregulatory health, it was calculated using a continuous moving Pearson correlation of 30 consecutive and paired 10 s averaged values of ABP and rSO 2 that updated every minute [ 51 , 53 ]. Observationally, it was determined that CO x _a < 0 indicated intact CA, and CO x _a > 0.3 indicated grossly impaired CA [ 51 , 54 , 55 , 56 ].…”

Section: Materials and Methodsmentioning

confidence: 99%

Evaluation of Morlet Wavelet Analysis for Artifact Detection in Low-Frequency Commercial Near-Infrared Spectroscopy Systems

Bergmann,

Froese,

Gomez

et al. 2023

Bioengineering

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Regional cerebral oxygen saturation (rSO2), a method of cerebral tissue oxygenation measurement, is recorded using non-invasive near-infrared Spectroscopy (NIRS) devices. A major limitation is that recorded signals often contain artifacts. Manually removing these artifacts is both resource and time consuming. The objective was to evaluate the applicability of using wavelet analysis as an automated method for simple signal loss artifact clearance of rSO2 signals obtained from commercially available devices. A retrospective observational study using existing populations (healthy control (HC), elective spinal surgery patients (SP), and traumatic brain injury patients (TBI)) was conducted. Arterial blood pressure (ABP) and rSO2 data were collected in all patients. Wavelet analysis was determined to be successful in removing simple signal loss artifacts using wavelet coefficients and coherence to detect signal loss artifacts in rSO2 signals. The removal success rates in HC, SP, and TBI populations were 100%, 99.8%, and 99.7%, respectively (though it had limited precision in determining the exact point in time). Thus, wavelet analysis may prove to be useful in a layered approach NIRS signal artifact tool utilizing higher-frequency data; however, future work is needed.

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