Cerebrovascular insufficiency and amyloidogenic signaling in Ossabaw swine with cardiometabolic heart failure

Baranowski, Bradley J.; Allen, Matti D.; Nyarko, Jennifer N.K.; Rector, R. Scott; Padilla, Jaume; Mousseau, Darrell D.; Rau, Christoph; Wang, Yibin; Laughlin, M. H.; Emter, Craig A.; MacPherson, Rebecca E. K.; Olver, T. Dylan

doi:10.1172/jci.insight.143141

Cited by 8 publications

(2 citation statements)

References 81 publications

(138 reference statements)

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“…Aortic constriction in combination with a high fat diet, have pointed the evidence between the association of HF with cerebrovascular failure, neuroinflammation and amyloidosis with preserved LVEF. At the molecular level and considering limitations that include a lack of nutritional control groups and histopathological data, a transcriptomic pattern can be obtained in animals subjected to aortic constriction typical of frontotemporal dementia and Alzheimer’s disease, implying the clear relationship between HF with preserved LVEF with cognitive impairment ( Baranowski et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Preclinical models of congestive heart failure, advantages, and limitations for application in clinical practice

2022

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Congestive heart failure (CHF) has increased over the years, in part because of recent progress in the management of chronic diseases, thus contributing to the maintenance of an increasingly aging population. CHF represents an unresolved health problem and therefore the establishment of animal models that recapitulates the complexity of CHF will become a critical element to be addressed, representing a serious challenge given the complexity of the pathogenesis of CHF itself, which is further compounded by methodological biases that depend on the animal species in use. Animal models of CHF have been developed in many different species, with different surgical procedures, all with promising results but, for the moment, unable to fully recapitulate the human disease. Large animal models often provide a more promising reality, with all the difficulties that their use entails, and which limit their performance to fewer laboratories, the costly of animal housing, animal handling, specialized facilities, skilled methodological training, and reproducibility as another important limiting factor when considering a valid animal model versus potentially better performing alternatives. In this review we will discuss the different animal models of CHF, their advantages and, above all, the limitations of each procedure with respect to effectiveness of results in terms of clinical application.

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Section: Introductionmentioning

confidence: 99%

Preclinical models of congestive heart failure, advantages, and limitations for application in clinical practice

2022

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“…The ninth study reported the activation of MAPK pathway and reduced NO signaling as contributors to CI. Other contributors include amyloidogenic processing and thus increased β-amyloid in the prefrontal cortex and hippocampus and neuroinflammation evident from increased ERK, JNK and p38 ( 48 ).…”

Section: Resultsmentioning

confidence: 99%

The pathophysiology of cognitive impairment in individuals with heart failure: a systematic review

Ni,

Mohamed Raffi,

Dong

2023

Front. Cardiovasc. Med.

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IntroductionHeart Failure and Cognitive Impairment are both on the rise and shown to be interlinked. Despite existing reviews delineating a relationship between heart failure and cognitive impairment, the underlying pathophysiology is not researched in great depth. Current literature proposed varying pathophysiological mechanisms and focused heavily on the prevalence of cognitive impairment and treatment interventions such as cardiac rehabilitation. In view of the limitations of previous reviews, this systematic review summarized the best existing evidence concerning different pathophysiological mechanisms behind cognitive impairment in individuals with heart failure.MethodsEight electronic databases including PubMed, Cochrane Library and EMBASE etc., two grey literatures (ProQuest Theses and Dissertations and Mednar) and hand-searching of references were performed using specific criteria regarding population, exposures and outcomes, before duplicate removal and screening using Endnote and Rayyan respectively. JBI critical appraisal tools for non-randomized studies were used for appraisal. Data extraction was performed using two modified forms from JBI Manual for Evidence Synthesis.ResultsNarrative synthesis was performed to summarize the data from 32 studies. There were three main themes—cognitive impairment due to changes in the brain: brain atrophy, alterations in grey matter and white matter, cerebral alterations, pathway or axis changes, neuroinflammation and hippocampal gene changes; cognitive impairment due to changes in the heart or systemic circulation: inflammation, oxidative stress and changes in serum biomarkers or proteins and the riser rhythm; cognitive impairment due to changes in both the brain and the heart, with seven studies obtaining negative results. There are some limitations such as having non-human studies and large numbers of cross-sectional studies etc.DiscussionConsidering the findings, future research should examine the bi-directional relationship between the brain and the heart as most of the existing research is about the effect of the heart on the brain. By understanding the different pathophysiological mechanisms, the management and prognosis of heart failure patients will be ameliorated. Interventions that slow down or even reverse cognitive impairment can be explored so that these two common issues will not add to the already aggravating disease burden.Systematic Review RegistrationThis review is registered under PROSPERO. Identifier: CRD42022381359.

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Cognitive decline in heart failure: Biomolecular mechanisms and benefits of exercise

Maroofi

Moro

Agrimi

et al. 2022

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Cerebrovascular insufficiency and amyloidogenic signaling in Ossabaw swine with cardiometabolic heart failure

Cited by 8 publications

References 81 publications

Preclinical models of congestive heart failure, advantages, and limitations for application in clinical practice

Preclinical models of congestive heart failure, advantages, and limitations for application in clinical practice

The pathophysiology of cognitive impairment in individuals with heart failure: a systematic review

Cognitive decline in heart failure: Biomolecular mechanisms and benefits of exercise

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