Cerebrovascular disease in children under 16 years of age in the city of Dijon, France: A study of incidence and clinical features from 1985 to 1993

Giroud, Maurice; Lemesle, M.; Gouyon, Jean‐Bernard; Nivelon, J L; Milan, Chantal; Dumas, R

doi:10.1016/0895-4356(95)00039-9

Cited by 318 publications

(205 citation statements)

References 19 publications

Supporting

Mentioning

174

Contrasting

Unclassified

Order By: Relevance

“…Its overall incidence has been estimated to be 2.5 cases in 100,000 per year [2], with 44% to 61% of ischemic origin [2][3][4]. Awareness of etiologic factors is essential because recurrence is significant and disabilities are frequent, endangering quality of life [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

Inherited and acquired risk factors and their combined effects in pediatric stroke

Barreirinho

Ferro

Santos

et al. 2003

Pediatric Neurology

View full text Add to dashboard Cite

The aim of this study was to identify hereditary and acquired risk-factors as they are related to the occurrence of stroke in children. We identified 21 children with stroke. A search of the Factor V Leiden mutation, the Factor II G20210A variant, and the thermolabile variant of methylenetetrahydrofolate reductase was performed in patients and in a control group (n ‫؍‬ 115).We identified risk factors of acquired and/or hereditary nature for stroke in 19 of 21 children. Eleven children had three or more risk factors, seven had two risk factors, and one child had only one risk factor. We found three carriers (14.3%) of the Factor V Leiden mutation, two carriers (9.5%) of the Factor II G20210A variant, eleven (52.4%) thermolabile variant of methylenetetrahydrofolate reductase heterozygote carriers, and one (4.8%) homozygotes for this variant.Frequencies of the Factor V Leiden mutation and the Factor II variant were higher in patients than in controls, suggesting that these variants are associated with an increased risk of stroke in childhood. Homozygosity for the thermolabile variant of methylenetetrahydrofolate reductase was equally frequent amongst patients and controls.Our study confirms that stroke in children is commonly associated with a combination of multiple risk factors, both genetic and acquired, and that the Factor V Leiden mutation and the Factor II G20210A variant are predisposing factors for this situation.

show abstract

Section: Introductionmentioning

confidence: 99%

Inherited and acquired risk factors and their combined effects in pediatric stroke

Barreirinho

Ferro

Santos

et al. 2003

Pediatric Neurology

View full text Add to dashboard Cite

show abstract

“…Compared with adults, arterial ischemic stroke (AIS) in children is uncommon, occurring at rates of 1.8 to 3.3 cases per 100 000 children per year [2][3][4] and has better overall outcomes. Full recovery is reported in 33% of newborn infants and 31% of children compared with 10% of adults.…”

mentioning

confidence: 99%

Basilar artery strokes in children: good outcomes with conservative medical treatment

Lagman-Bartolome

Pontigon

Moharir

et al. 2013

Develop Med Child Neuro

View full text Add to dashboard Cite

Aim To describe outcomes and outcome predictors in childhood basilar artery stroke (BAS). Method We prospectively enrolled children with BAS with or without basilar artery occlusion (BAO) in the Toronto Children's Stroke Registry from 1992 to 2009. We assessed presenting features and outcomes including Pediatric Stroke Outcome Measure scores. Results Among 578 children with acute arterial ischemic stroke, 27 had BAS (4.6% including neonates, 6% excluding neonates). Twenty‐four (14 males, 10 females) children met study criteria (mean age at stroke was 8y 10mo; range 0–17y). Eleven children had BAO. Aspirin or anticoagulation was given to 15 children. None received tissue plasminogen activator or endovascular treatments. At mean follow‐up (3y 2mo, range 1mo–11y 8mo), 12 had a ‘good outcome’ (seven normal, five insignificant deficit) and 12 had ‘poor outcome’ (10 moderate or severe deficit, two acute deaths). Larger infarct size (≥50% of axial brainstem diameter) independently predicted poor outcome (p=0.02; odds ratio 21.2, 95% confidence interval 1.6–274.9) but not BAO, altered level of consciousness, or age. Interpretation Compared with adults, in childhood BAS death is rare and survivors frequently have good outcomes. Aggressive endovascular interventions may not be justifiable in this population.

show abstract

“…The estimated yearly incidence of stroke in childhood is between 3-8 per 100,000. (Giroud et al, 1995;Lynch et al, 2002). The highest incidence of 25-35 per 100,000 live births has been reported for neonates (Chalmer, 2005).…”

Section: Epidemiologymentioning

confidence: 99%

Venous Thromboembolism in Neonates, Children and Patients with Chronic Renal Disease – Special Considerations

Lázaro¹,

Arriola²,

Romero³

et al. 2012

Pathophysiology and Clinical Aspects of Venous Thromboembolism in Neonates, Renal Disease and Cancer Patients

View full text Add to dashboard Cite

Cerebrovascular disease in children under 16 years of age in the city of Dijon, France: A study of incidence and clinical features from 1985 to 1993

Cited by 318 publications

References 19 publications

Inherited and acquired risk factors and their combined effects in pediatric stroke

Inherited and acquired risk factors and their combined effects in pediatric stroke

Basilar artery strokes in children: good outcomes with conservative medical treatment

Venous Thromboembolism in Neonates, Children and Patients with Chronic Renal Disease – Special Considerations

Contact Info

Product

Resources

About