Cerebrospinal Fluid Vasopressin Levels

Coccaro, Emil F.; Kavoussi, Richard J.; Hauger, Richard L.; Cooper, Thomas B.; Ferris, Craig F.

doi:10.1001/archpsyc.55.8.708

Cited by 332 publications

(62 citation statements)

References 51 publications

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“…It might also increase the likelihood of eliciting aggressive responses from others as a result of having sent such an agonistic signal. Such mechanisms could, at least in part, explain the positive correlation between levels of AVP in the CSF of men with personality disorders and aggressive life histories (2).…”

Section: Discussionmentioning

confidence: 99%

Sex-specific influences of vasopressin on human social communication

Thompson

George

Walton

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

272

149

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Arginine vasopressin (AVP) and related peptides affect social behaviors in numerous species, but AVP influences on human social functions have not yet been established. Here, we describe how intranasal AVP administration differentially affects social communication in men and women, and we propose a mechanism through which it may exert those influences. In men, AVP stimulates agonistic facial motor patterns in response to the faces of unfamiliar men and decreases perceptions of the friendliness of those faces. In contrast, in women, AVP stimulates affiliative facial motor patterns in response to the faces of unfamiliar women and increases perceptions of the friendliness of those faces. AVP also affected autonomic responsiveness to threatening faces and increased anxiety, which may underlie both communication patterns by promoting different social strategies in stressful contexts in men and women.affiliation ͉ aggression ͉ anxiety ͉ autism ͉ emotion C entral arginine vasopressin (AVP; mammals) and arginine vasotocin (AVT; nonmammalian homologue) systems modulate social behaviors in numerous species from diverse vertebrate groups (1). It has therefore been proposed that social functions of these peptides were highly conserved during vertebrate evolution and, if retained in humans, that variations in the AVP system may be related to individual differences in sociality in our own species, particularly aggressive (2) and͞or affiliative (3, 4) tendencies. It has even been hypothesized that extreme variations in the AVP system may be related to the social dysfunctions associated with autism (5-7).Among the social processes most consistently influenced by AVP and AVT in animal models are those related to social communication, particularly the generation of, and͞or responses to, stereotypical signals associated with courtship and aggression. In humans, facial expressions are associated with such forms of emotional communication (8), so we predicted that AVP would influence the motor patterns associated with facial responses to social stimuli, particularly in men, because AVP͞ AVT systems are most often associated with the regulation of male-typical patterns of social communication (1). Indeed, in a preliminary study, we showed that electromyographic (EMG) responses of the corrugator supercilii, which are associated with threat (9), are increased in men by intranasal AVP administration (10). However, we do not yet know whether AVP also modulates social communication in women, which is an intriguing possibility because sexual dimorphisms typical of AVP͞AVT systems in other species in which males have more AVP͞AVT-producing cells and͞or fiber projections have not been detected in human brains (11). We also do not yet know whether AVP can influence social cognition as well as facial motor patterns related to social communication, nor anything about the mechanisms through which AVP may affect social communication in humans.To address these fundamental questions and to determine how rapidly social processes are affected by intr...

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Section: Discussionmentioning

confidence: 99%

Sex-specific influences of vasopressin on human social communication

Thompson

George

Walton

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

272

149

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“…This is not surprising because: (a) regardless of the 5-HT index used only the activity of a part of the system can be quantified; (b) 5-HT agents have varying effects on the 5-HT synapse (e.g., pre-vs. postsynaptic effects); and (c) other neurotransmitters working to inhibit, or to facilitate, aggression are relevant as well. Other inhibitory neurotransmitters/modulators include, but are not limited to, GABA (Lee, Petty, & Coccaro, 2009) and oxytocin (Lee, Ferris, Van de Kar, & Coccaro, 2009); facilitatory neurotransmitter/ modulators include glutamate (Coccaro, Lee, & Vezina, 2013), vasopressin (Coccaro, Kavoussi, Hauger, Cooper, & Ferris, 1998), neuropeptide Y (Coccaro, Lee, Liu, & Mathe, 2012), substance P (Coccaro, Lee, Owens, Kinkead, & Nemeroff, 2012), and inflammatory cytokines (Coccaro, Lee, & Coussons-Read, 2014). …”

Section: Aggression and Neurotransmittersmentioning

confidence: 99%

The nature of impulsive aggression: Commentary on “Aggression in borderline personality disorder—A multidimensional model”.

Coccaro

2015

Personality Disorders: Theory, Research, and Treatment

Self Cite

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Comments on the article by F. Mancke et al. (see record 2015-31349-001). The article by Mancke et al. is an excellent review and synthesis of extant data to reformulate the phenomenon of aggression in borderline personality disorder (BPD) into a multidimensional model. It attempts to conceptualize aggression from the biobehavioral dimensions of affect dysregulation, impulsivity, threat hypersensitivity, and cognitive empathy based on data from self-reports and behavioral tasks, neuroimaging, neurochemistry, and psychophysiology. This is a clear contribution to the field. In this commentary, I will focus on some issues that reinforce the points they make in their excellent paper and/or add to them.

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“…CSF vasopressin concentration is positively correlated with a history of disinhibited aggression, including temper tantrums and physical aggression in patients with intermittent explosive disorder, many of whom have comorbid borderline personality disorder (127). However, one study found no differences in CSF vasopressin between violent offenders and comparison subjects (128), which raises the possibility that the vasopressin increases may be particularly associated with aggression in an interpersonal context in those who are interpersonally sensitive and not in antisocial individuals lacking interpersonal sensitivity.…”

Section: The Vasopressin System and Borderline Personality Disordermentioning

confidence: 99%

“…Vasopressin in CSF is correlated with aggression in individuals with personality disorders, while vasopressin concentrations are inversely associated with prolactin responses to fenfluramine, an index of serotonergic capacity (127), which suggests that these two systems may interact reciprocally to modulate aggression. Individuals with borderline personality disorder who have reduced serotonergic activity may have increased vasopressin concentrations associated with aggression toward peers, consistent with their lowered threshold for anger and aggression.…”

Section: The Vasopressin System and Borderline Personality Disordermentioning

confidence: 99%

The Interpersonal Dimension of Borderline Personality Disorder: Toward a Neuropeptide Model

Stanley¹,

Siever²

2010

AJP

239

152

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Borderline personality disorder is characterized by affective instability, impulsivity, identity diffusion, and interpersonal dysfunction. Perceived rejection and loss often serve as triggers to impulsive, suicidal, and self-injurious behavior, affective reactivity, and angry outbursts, suggesting that the attachment and affiliative system may be implicated in the disorder. Neuropeptides, including the opioids, oxytocin, and vasopressin, serve a crucial role in the regulation of affiliative behaviors and thus may be altered in borderline personality disorder. While clinical data are limited, the authors propose alternative neuropeptide models of borderline personality disorder and review relevant preclinical research supporting the role of altered neuropeptide function in this disorder in the hope of stimulating more basic research and the development of new treatment approaches.

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Cerebrospinal Fluid Vasopressin Levels

Cited by 332 publications

References 51 publications

Sex-specific influences of vasopressin on human social communication

Sex-specific influences of vasopressin on human social communication

The nature of impulsive aggression: Commentary on “Aggression in borderline personality disorder—A multidimensional model”.

The Interpersonal Dimension of Borderline Personality Disorder: Toward a Neuropeptide Model

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