Cerebrospinal-Fluid Proteins, Glycoproteins, and Lipoproteins in Obstructive Lesions of the Central Nervous System

Hill, Norman C.; Goldstein, Norman; McKenzie, Bernard F.; McGuckin, Warren F.; Svien, Hendrik J.

doi:10.1093/brain/82.4.581

Cited by 46 publications

(11 citation statements)

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“…In the IV obstruction we found an increase in the prealbumin and/or albumin in the ventricular fluid, and an electrophoretogram within the normal ranges in the lumbar fluid. These results are similar to those reported by Hill et al [8] for ventricular CSF in obstructive hydrocephalus an increase in the per meability of the B-CSF-B, at the ventricular region, might be reflected by an increase of the prealbumin and albumin fractions in the ventricular fluid. In experimental ventricular obstruction, electron microscopy showed an altera tion in the ependymal structures, and edema of the periventricular white matter (12).…”

Section: Discussionsupporting

confidence: 92%

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Polyacrylamide Gel Electrophoresis of Cerebrospinal Fluid Proteins in Children with Nontumoral Hydrocephalus

Cerda¹,

Vielma²,

Martínez³

et al. 1980

Pediatr Neurosurg

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The changes occurring in the electrophoretic pattern of the cerebrospinal fluid (CSF) proteins in 37 children with nontumoral hydrocephalus, and the protein pattern of 12 children without organic neurological disease, were studied with polyacrylamide gel electrophoresis. In nontumoral hydrocephalus protein was frequently increased in lumbar and ventricular fluid, in this condition, in intraventricular obstruction, the protein fractions showed a decrease in the prealbumin and an increase in the γ-globulin fractions, and in extraventricular obstruction, the protein fractions showed a decrease in the prealbumin and an increase in the γ-globulin and α₂-globulin fractions. With CSF proteins within normal ranges we found that in intraventricular obstruction, the proteins of the ventricular CSF showed an increase in the prealbumin and/or albumin fractions, and in extraventricular obstruction, the proteins of the ventricular CSF showed an increase in the prealbumin and β-globulin fractions, and the proteins of the lumbar CSF showed an increase in the prealbumin fraction. The diagnostic implications of these findings are discussed.

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Section: Discussionsupporting

confidence: 92%

“…Impair ment of the B-CSF-B with increased protein permeability might be assumed in the lumbar fluid with an increase of y-globulin and «-globulin. An increase in the «.2-gIobulin with normal contents of y-globulin was also found in 3 of 5 ventricular fluids studied by Hill et al [8].…”

Section: Discussionsupporting

confidence: 58%

Polyacrylamide Gel Electrophoresis of Cerebrospinal Fluid Proteins in Children with Nontumoral Hydrocephalus

Cerda¹,

Vielma²,

Martínez³

et al. 1980

Pediatr Neurosurg

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“…Classicamente o hematoma subdural crônico é definido como coleção sangüínea localizada entre a dura máter e a aracnóide 7 . O acúmulo de sangue apresenta como principal origem a lesão traumática dos vasos de Mittenzweig parassagitais 10 .…”

Section: Discussionunclassified

“…A teoria osmótica, proposta por Gardner 10 , recentemente tem sido questionada, pois em modelos experimentais praticamente não se verifica aumento de volume. Comprovou-se também que a albumina, a principal proteína osmoticamente ativa, não se origina da destruição de hemácias, mas tem origem plasmática 7 .…”

Section: Discussionunclassified

Hematoma subdural crônico: análise de 35 casos

Araújo

Iafigliola

Balbo

1996

Arq. Neuro-Psiquiatr.

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RESUMO -Os autores relatam 35 casos com diagnóstico de hematoma subdural crônico, operados no período de janeiro-1988 a março-1995. A idade dos pacientes variou entre 19 e 80 anos. Foram eles agrupados retrospectivamente segundo a escala de Bender. Quanto ao tratamento cirúrgico, foram empregadas duas técnicas: craniotomia com membranectomia e dupla trepanação com instilação de solução salina na cavidade ocupada pelo hematoma. O índice de mortalidade entre os pacientes submetidos à craniotomia foi 16,6% e nos pacientes submetidos à trepanação foi nulo. Dentre os pacientes que faleceram, 80% encontravam-se em grau III ou IV na escala de Bender. O hematoma subdural crônico apresenta até os dias atuais alguns aspectos controversos, como quanto à sua fisiopatologia e ao tratamento cirúrgico adequado.PALAVRAS-CHAVES: hematoma subdural crônico, craniotomia, trepanação. Chronic subdural hematoma: analysis of 35 casesABSTRACT -Thirty five patients with chronic subdural hematoma were treated surgically between 1988 and 1995. The patients, aged 19 to 80 years, were graded retrospectively according to the Bender scale. The clots were removed via burr-holes with irrigation of the subdural space to ensure as complete an evacuation of subdural colletion, and craniotomy with membranectomy. The mortality rate was 16.6% with craniotomy and 0% with burr-hole. The patients who died, 80% were in grade III or IV. The pathogenesis and surgical treatment of chronic subdural hematoma has been controversial, and still remains obscure.KEY WORDS: chronic subdural hematoma, craniotomy, burr-hole evacuation.Os hematomas subdurals crônicos constituem condição neurocirúrgica potencialmente curável através de vários métodos cirúrgicos, mas ainda nos dias atuais com significativos índices de mortalidade, sendo a cura espontânea considerada ra ra 1,5,10,1214 .Uma série de 35 pacientes com diagnóstico de hematoma subdural crônico é apresentada e analisada frente a revisão bibliográfica do assunto. PACIENTES E MÉTODOSTrinta e cinco pacientes com o diagnóstico de hematoma subdural crônico foram tratados no período de janeiro-1988 a março-1995. Destes, 27 pacientes eram do sexo masculino e 8 do sexo feminino. A idade variou entre 19 a 80 anos, em 60% estando acima de 60 anos. O antecedente de traumatismo craniano estava presente em 68% dos casos.

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“…There are few reports about cerebrospinal fluid (CSF) proteins in infan tile hydrocephalus (1)(2)(3)6], In a previous report [6] we had made the correla tion of CSF protein electrophoretic patterns with some etiological factors in infantile hydrocephalus. The present paper describes characteristic abnor malities of CSF proteins in 2 hydrocephalic children.…”

Section: Introductionmentioning

confidence: 99%

Peculiar Cerebrospinal Fluid Protein Patterns in Two Cases of Infantile Hydrocephalus

Silva¹,

Lavandeira²,

Fontes³

1980

Pediatr Neurosurg

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Cerebrospinal fluid (CSF) protein abnormalities in 2 hydrocephalic children are described. 1 of the cases presented a degenerative pattern in lumbar CSF protein electrophoresis in spite of high total protein content. This is thought to be due to an excess of tissue proteins as a result of abnormal conditions of circulation and absorption of CSF in hydrocephalus. The other case makes clear the role of inflammation on CSF protein electrophoretic patterns.

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Cerebrospinal-Fluid Proteins, Glycoproteins, and Lipoproteins in Obstructive Lesions of the Central Nervous System

Cited by 46 publications

References 0 publications

Polyacrylamide Gel Electrophoresis of Cerebrospinal Fluid Proteins in Children with Nontumoral Hydrocephalus

Polyacrylamide Gel Electrophoresis of Cerebrospinal Fluid Proteins in Children with Nontumoral Hydrocephalus

Hematoma subdural crônico: análise de 35 casos

Peculiar Cerebrospinal Fluid Protein Patterns in Two Cases of Infantile Hydrocephalus

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