Cerebrospinal fluid production is reduced in healthy aging

May, Conrad; Kaye, Jeffrey; Atack, John; Schapiro, Mark B.; Friedland, R. P.; Rapoport, Stanley I.

doi:10.1212/wnl.40.3_part_1.500

Cited by 268 publications

(188 citation statements)

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“…Whether this is an indirect effect due to overall dysregulation of genes involved in cholesterol homeostasis remains to be determined. Modification of the choroid plexus with age is related to a lower rate of CSF secretion in elderly individuals (32,33). In Alzheimer's disease, there is thickening of the basement membrane of the choroid plexus and flattening of epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration

Wang

Schuster

Hultenby

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

255

217

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Section: Discussionmentioning

confidence: 99%

Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration

Wang

Schuster

Hultenby

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

255

217

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“…On the other hand, among older volunteers, no significant difference has been shown between other cognitive disorders and CSF flow rate, and thus the prediction of the potential benefit from surgery. Some consider flow velocity and rate measurements adequate for a differential diagnosis and the prediction of the benefit from surgery, but others think the opposite (4,11,14,17).…”

Section: Discussionmentioning

confidence: 99%

“…Various parameters, i.e., time, velocity, and flow, have been used to examine CSF flow dynamics (8,14,10,20). There are differing opinions as to whether measuring aqueductal CSF flow velocity and flow rate contributes to a differential diagnosis of NPH or on in the decision-making regarding shunt therapy (6).…”

Section: Discussionmentioning

confidence: 99%

Normal pressure hydrocephalus versus atrophic dilatation to distinguish and predict the benefits of surgical intervention with a phase-contrast MRI technique

Aslan¹,

Tokatlioğlu²,

Aydin³

et al. 2014

Turkish Neurosurgery

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AIM:To compare mean cerebrospinal fluid (CSF) volume in the aqueduct by using phase-contrast magnetic resonance imaging for the patients with idiopathic normal pressure hydrocephalus (INPH) and atrophic dilation (AD) to investigate the efficacy of this technique in predicting surgery. MATERIAL and METHODS:The MR images of a total of 80 individuals, consisting of 30 patients considered to have INPH, 20 patients with AD not proportional with cerebral sulci, and 30 control cases without a hydrocephalus clinical picture, were evaluated retrospectively. The minute mean aqueductal CSF flow rates of the three groups were compared using the Kruskall-Wallis analysis of variance, and the inter-group statistical comparisons were made using the Mann-Whitney U test. RESULTS:The mean aqueductal flow rates were 46.56 ± 25.06 ml/min for the INPH group, 9.28 ± 4.68 ml/min for the AD group, and 8.68 ± 3.40 ml/min for the control group. The mean flow rate of the INPH group was significantly higher than those of the control and ADH groups (p < 0.001). CONCLUSION:The mean CSF flow rate may be useful in the diagnosis and differential diagnosis, and the prediction of the potential benefits of surgical intervention for patients considered to have INPH.KEywORDS: Phase-contrast magnetic resonance imaging, Normal pressure hydrocephalus, Cerebrospinal fluid ÖZ AMAÇ: Faz kontrast manyetik rezonans görüntüleme kullanarak, idiyopatik normal basınçlı hidrosefali (İNBH) li hastalar ile atrofik dilatasyonu (AD) bulunan hastalarda akuaduktustaki ortalama beyin omurilik sıvısı (BOS) volümünü karşılaştırmak ve bu tekniğin cerrahi yararı öngörmedeki etkinliğini araştırmaktır. yÖNTEM ve GEREÇLER: İNBH olarak değerlendirilen 30 hasta, serebral sulkuslar ile orantısız AD bulunan 20 hasta, hidrosefali kliniği bulunmayan kontrol grubu 30 olgu olmak üzere toplam 80 olgunun MR görüntüleri retrospektif olarak incelendi. Üç grup arasında akuaduktustaki dakikalık ortalama BOS debileri Kruskall-Wallis varyans analizi ile, gruplar birbirleri ile Mann-Whitney U testi ile istatistiksel olarak karşılaştırıldı. BULGULAR:Akuaduktus düzeyinden elde edilen ortalama debi değerleri; İNBH grubunda 46,56 ± 25,06 ml/dk, AD grubunda 9,28 ± 4,68 ml/ dk, kontrol grubunda 8,68 ± 3,40 ml/dk idi. İNBH grubundaki ortalama debi, kontrol grubu ve AD grubu ile karşılaştırıldığında istatistiksel olarak anlamlı fazla bulundu (p < 0,001). SONUÇ:Ortalama BOS debi oranları, İNBH düşünülen olgularda tanıda, ayırıcı tanıda ve cerrahi yararı öngörmede faydalı olabilir.ANAHTAR SÖZCÜKLER: Faz kontrast manyetik rezonans görüntüleme, Normal basınçlı hidrosefali, Beyin omurilik sıvısı

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“…May et al [27] found in elderly healthy individuals a significantly lower CSF production compared with healthy young subjects.…”

Section: Figure 25 Choroid Plexus and Arachnoid Granulations Adaptementioning

confidence: 96%

“…Invasive methods and imaging-based approaches have reported a large range of results (0.35 -0.7 ml/min) [26][27][28][29][30].…”

Section: Figure 25 Choroid Plexus and Arachnoid Granulations Adaptementioning

confidence: 99%

Intracranial fluids dynamics: a quantitative evaluation by means of phase-contrast magnetic resonance imaging

Ordoñez¹,

Natalia²

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A mis padres Cecilia y Justo Pastor, por todos los principios éticos y morales impartidos;que prevalecerán durante toda mi vida. Al mayor regalo que Dios trajo a mi familia, María del Pilar. Gracias por enseñarme a valorar el sentido de la vida.A Elvis por toda la paciencia, amor y comprensión que día a día me fortalecieron. AcknowledgmentsDuring the development of this thesis, I have met many people and I learnt from all of them. Besides this, many people helped indirectly to the realization of this thesis helping me to feel at home in this foreign country. I hope I can express my gratitude to all of them and apologize in case I forget somebody. Dr. Luís Martí-Bonmatí, first of all I would like to thank him for offering me the opportunity to do research with him. Over time I have collected lots of "paper tablecloths" of the Italian restaurant, where we discussed step by step the different points that allowed the development of this thesis. I feel great admiration because he is able to transmit and share his knowledge in a polite way and I am especially thankful that he shared it with me during all these years. These techniques also must take into account the errors associated with the partial volume effect (PVE), caused by the presence of stationary tissue and flow inside the voxels of the periphery of the region under study.The overall objective of this thesis was to develop a reproducible methodology to quantitatively evaluate the intracranial fluids dynamics within CSF spaces (aqueduct of Sylvius, prepontine cistern and subarachnoid space C2C3) and main cerebral blood vessels (carotids and vertebral arteries, jugular veins, straight and sagittal superior sinus) by means of PC-MRI. This methodology includes semiautomatic segmentation techniques by thresholding and K-means clustering that allow to delineate the ROI with great independency of the observer and to apply background and aliasing correction.Amplitude parameters (increase of flow volume in systole, mean flows, pulsatility, compliance indexes and supratentorial CSF) and temporal parameters (delay respect to the inflow blood to the brain) were quantified. The distribution of the pulsatibility of the CSF flow between the ventricular and subarachnoid spaces was measured as the ratio of aqueductal to C2C3 cervical stroke volume.The commitment between the acquisition protocol and the used methodology to calculate each one of the parameters has helped to establish reliable and reproducible normality ranges for each one of them. The evaluated control subjects were asymptomatic and they had no history of intracranial hypertension, neurological disease, vascular events or relevant risks factors allowing to generalize the measures. They were studied at the same hourly stripe to avoid influences of the circadian cycle. All acquisitions were carried with a 3.0T MR unit to avoid the influence of the field strength on parameters.In conclusion an adequate methodology was developed to carry out quick ResumenEl volumen intracraneal lo integran el volumen de líquido ...

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Cerebrospinal fluid production is reduced in healthy aging

Cited by 268 publications

References 0 publications

Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration

Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration

Normal pressure hydrocephalus versus atrophic dilatation to distinguish and predict the benefits of surgical intervention with a phase-contrast MRI technique

Intracranial fluids dynamics: a quantitative evaluation by means of phase-contrast magnetic resonance imaging

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