Cerebrospinal Fluid Pressure Is Decreased in Primary Open-angle Glaucoma

Berdahl, John P.; Allingham, R. Rand; Johnson, Douglas H.

doi:10.1016/j.ophtha.2008.01.013

Cited by 380 publications

(340 citation statements)

References 21 publications

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“…15 This may not come as a surprise, as the POAG phenotype itself seems complex and to result from diverse pathological processes that involve, but are not limited to, the retina and optic nerve, the aqueous humor outflow pathways and even, as suggested recently, the cerebrospinal fluid dynamics. 16 In 2000, Wiggs et al 17 published a first genome-wide linkage scan involving an initial set of 41 multiplex families and a second one of 33, where several loci, including regions on chromosome 2, 14, 17 and 19, were linked to POAG. We, therefore, focused our efforts on chromosomal region 14q11.…”

Section: Introductionmentioning

confidence: 99%

Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma

et al. 2011

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Section: Introductionmentioning

confidence: 99%

Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma

et al. 2011

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“…The sample size was calculated using a web based statistical software available at http://www.stat.ubc.ca/~rollin/stats/ssize/n2.html. With an α error of 5% and β error of 20%, mean CSFP in OH of 16 mmHg and 12.9 mmHg in controls and standard deviation of 2.5 mmHg, the minimum required sample size was calculated as 11 in each group [4,21].…”

Section: Methodsmentioning

confidence: 99%

“…Recent experimental and clinical investigations have provided evidence that an abnormally low orbital Cerebral Spinal Fluid Pressure (CSFP) may result in elevated Trans-Laminar Cribrosa Pressure Difference (TLCPD) that could be associated with the pathogenesis of POAG, especially normal tension glaucoma [2][3][4][5][6][7][8][9]. OH is often considered the opposite end of the glaucoma spectrum to normal tension glaucoma.…”

Section: Introductionmentioning

confidence: 99%

“…The assessment of the CSFP and TLCPD in therefore mentioned clinical studies was based on a single lumbar CSFP measurement, not the more relevant (and more difficult) measurement of the orbital CSFP [4][5][6][7]. While direct measurement of orbital CSFP is invasive and currently impossible in clinical practice, high-resolution MRI has been reported to be a reliable measure of optic nerve, optic nerve sheath and peripheral cerebrospinal fluid with good inter-and intra-observer agreement [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Non-invasive Evaluation of Cerebrospinal Fluid Pressure in Ocular Hypertension: The Beijing Intracranial and Intraocular Pressure Study

Xie¹,

Chen²,

Li³

et al. 2017

J Clin Exp Ophthalmol

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Objective: To compare the orbital CSFP and trans-lamina cribrosa pressure difference (TLCPD) determined noninvasively in Ocular Hypertension (OH) and controls, and study its association with the estimated risk of conversion to glaucoma. Design:Cross-sectional observational study. Participants Methods:Magnetic resonance imaging was used to measure orbital subarachnoid space width (OSASW) at 3, 9 and 15 mm posterior to the globe. The CSFP (mmHg) was estimated from a published formula as 17.54 × MRI derived OSASW at 15 mm behind the globe +0.47 × body mass index +0.13 × mean arterial blood pressure -21.52. Estimated TLCPD was calculated as IOP-CSFP. The values of CSFP and TLCPD were compared between OH and controls. The estimated risk of progression to glaucoma in OH was calculated and its correlation with CSFP determined. Main outcome measures:Orbital subarachnoid space width; MRI derived CSFP value; TLCPD value. Association of risk of progression with CSFP. Results:The orbital subarachnoid space width was significantly wider (P=0.01) in the OH group than in the control groups at all three measurement locations. The MRI derived CSFP value in OH (14.9 ± 2.9 mmHg) was significantly higher than in the normal group (12.0 ± 2.8 mmHg; P<0.01). The estimated TLCPD value in OH (9.0 ± 4.2 mmHg) was significantly higher than in controls (3.6 ± 3.0 mmHg; P<0.01). The estimated risk of conversion to glaucoma in OH (15.2 ± 8.7%) was negatively correlated with the MRI derived CSFP value (r=-0.51, r2=-0.26, P<0.01). Conclusions:The wider OSASW and higher estimated CSFP in OH subjects suggest a higher orbital CSFP. Despite a higher orbital CSFP that could be protective, the higher TLCPD in OH may play a significant role in the risk of developing glaucoma.

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“…6 This hypothesis is supported by recent experimental and clinical data showing an association between the occurrence of normal-pressure glaucoma and decreased CSF pressure. [6][7][8][9] In this work, we present 11 patients referred to our institution for severe open-angle glaucoma in whom MR imaging demonstrated the presence of a retrolaminar paraoptic cyst at the head of the optic nerve. We collected the ophthalmologic reports of these patients, together with the results of MR imaging of the optic nerves and, when available, high-resolution MR imaging and Doppler ultrasound (US) examination of the optic nerves.…”

mentioning

confidence: 99%

Open-Angle Glaucoma and Paraoptic Cyst: First Description of a Series of 11 Patients

Bertrand

Vignal

Lafitte³

et al. 2015

AJNR Am J Neuroradiol

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SUMMARY:We report 11 patients who were referred to our institution for severe open-angle glaucoma who had a paraoptic cyst on MR imaging. All cysts were extraoptic and retrolaminar; most were deforming the adjacent optic nerve. Cysts had a high signal on T2 and FLAIR sequences, and a variable signal on T1 and variable echogenicity, suggesting different proteinaceous content. Arterial vascularization of the optic nerve was normal. Cyst volumes were inversely correlated with the severity of glaucoma on the same eye (P Ͻ .01-.05, Spearman correlation coefficient). We hypothesized that such cysts may reflect a valve mechanism, which would allow preservation of the translamina cribrosa pressure and thus could preserve visual function. The rarity of this association, together with the frequent mass effect of the cyst on the optic nerve, stresses the necessity of long-term follow-up in these patients. ABBREVIATIONS:MD ϭ mean deviation; OCT ϭ optical coherence tomography; PSD ϭ pattern standard deviation; US ϭ ultrasound

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Cerebrospinal Fluid Pressure Is Decreased in Primary Open-angle Glaucoma

Cited by 380 publications

References 21 publications

Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma

Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma

Non-invasive Evaluation of Cerebrospinal Fluid Pressure in Ocular Hypertension: The Beijing Intracranial and Intraocular Pressure Study

Open-Angle Glaucoma and Paraoptic Cyst: First Description of a Series of 11 Patients

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