Cerebrospinal fluid of patients administered moxifloxacin modulates the secretion of cytokines from human monocytes

Giamarellos‐Bourboulis, Evangelos J.; Douzinas, E.; Τσαγανός, Θωμάς; Pagoulatou, Alexandra; Livaditi, Olga; Vafiadou, M.; Kanellakopoulou, Kyriaki

doi:10.1016/j.diagmicrobio.2008.09.003

Cited by 3 publications

(2 citation statements)

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“…Resistance of S.aureus to methicillin and production of PVL were documented by the detection of the mec A gene and the luc S-PV gene respectively by PCR [14], [15]. PSSP has been isolated from a patient with LRTI and bacteremia and it has already been described in a previous study [16].…”

Section: Methodsmentioning

confidence: 99%

Effect of the Novel Influenza A (H1N1) Virus in the Human Immune System

Giamarellos‐Bourboulis

Rosario

Antonopoulou

et al. 2009

PLoS ONE

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BackgroundThe pandemic by the novel H1N1 virus has created the need to study any probable effects of that infection in the immune system of the host.Methodology/Principal FindingsBlood was sampled within the first two days of the presentation of signs of infection from 10 healthy volunteers; from 18 cases of flu-like syndrome; and from 31 cases of infection by H1N1 confirmed by reverse RT-PCR. Absolute counts of subtypes of monocytes and of lymphocytes were determined after staining with monoclonal antibodies and analysis by flow cytometry. Peripheral blood mononuclear cells (PBMCs) were isolated from patients and stimulated with various bacterial stimuli. Concentrations of tumour necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-18, interferon (FN)-alpha and of IFN-gamma were estimated in supernatants by an enzyme immunoassay. Infection by H1N1 was accompanied by an increase of monocytes. PBMCs of patients evoked strong cytokine production after stimulation with most of bacterial stimuli. Defective cytokine responses were shown in response to stimulation with phytohemagglutin and with heat-killed Streptococcus pneumoniae. Adaptive immune responses of H1N1-infected patients were characterized by decreases of CD4-lymphocytes and of B-lymphocytes and by increase of T-regulatory lymphocytes (Tregs).Conclusions/SignificanceInfection by the H1N1 virus is accompanied by a characteristic impairment of the innate immune responses characterized by defective cytokine responses to S.pneumoniae. Alterations of the adaptive immune responses are predominated by increase of Tregs. These findings signify a predisposition for pneumococcal infections after infection by H1N1 influenza.

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Section: Methodsmentioning

confidence: 99%

Effect of the Novel Influenza A (H1N1) Virus in the Human Immune System

Giamarellos‐Bourboulis

Rosario

Antonopoulou

et al. 2009

PLoS ONE

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“…Controlled trials in children and a small number of adults, suggest that meropenem has similar efficacy to cefotaxime or ceftriaxone in the treatment of bacterial meningitis 140 and may be useful in the future. Gatifloxacin and moxifloxacin penetrate the CSF well and experimental models support their potential role in the treatment of penicillin and cephalosporin-resistant meningitis, 141,142 however there is concern regarding the rapid emergence of resistance with fluoroquinolone treatment. 143 Intraventricular antimicrobial agents have been shown to be of use in nosocomial meningitis associated with extra ventricular drains, 144 but are not indicated in the management of adult community acquired bacterial meningitis.…”

Section: Alternative Antibiotic Therapy Approachesmentioning

confidence: 99%

The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults

McGill

Heyderman

Michael

et al. 2016

Journal of Infection

154

167

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Bacterial meningitis and meningococcal sepsis are rare conditions with high case fatality rates. Early recognition and prompt treatment saves lives. In 1999 the British Infection Society produced a consensus statement for the management of immunocompetent adults with meningitis and meningococcal sepsis. Since 1999 there have been many changes. We therefore set out to produce revised guidelines which provide a standardised evidence-based approach to the management of acute community acquired meningitis and meningococcal sepsis in adults. A working party consisting of infectious diseases physicians, neurologists, acute physicians, intensivists, microbiologists, public health experts and patient group representatives was formed. Key questions were identified and the literature reviewed. All recommendations were graded and agreed upon by the working party. The guidelines, which for the first time include viral meningitis, are written in accordance with the AGREE 2 tool and recommendations graded according to the GRADE system. Main changes from the original statement include the indications for pre-hospital antibiotics, timing of the lumbar puncture and the indications for neuroimaging. The list of investigations has been updated and more emphasis is placed on molecular diagnosis. Approaches to both antibiotic and steroid therapy have been revised. Several recommendations have been given regarding the follow-up of patients.

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A Review of Immunomodulatory Effects of Fluoroquinolones

Assar

Nosratabadi

Azad

et al. 2020

Immunological Investigations

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Past researches indicate that some types of antibiotics, apart from their antimicrobial effects, have some other important effects which indirectly are exerted by modulating and regulating the immune system's mediators. Among the compounds with antimicrobial effects, fluoroquinolones (FQs) are known as synthetic antibiotics, which exhibit the property of decomposing of DNA and prevent bacterial growth by inactivating the enzymes involved in DNA twisting, including topoisomerase II (DNA gyrase) and IV. Interestingly, immune responses are indirectly modulated by FQs through suppressing pro-inflammatory cytokines, such as interleukin 1 (IL-1), IL-6, tumor necrosis factor-alpha (TNF-α), and super-inducing IL-2, which tend to increase both the growth and activity of T and B lymphocytes. In addition, they affect the development of immune responses by influencing of expression of other cytokines and mediators. This study aims to review past research on the immunomodulatory effects of FQs on the expression of cytokines, especially IL-2 and to discuss controversial investigations.

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Cerebrospinal fluid of patients administered moxifloxacin modulates the secretion of cytokines from human monocytes

Cited by 3 publications

References 15 publications

Effect of the Novel Influenza A (H1N1) Virus in the Human Immune System

Effect of the Novel Influenza A (H1N1) Virus in the Human Immune System

The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults

A Review of Immunomodulatory Effects of Fluoroquinolones

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