Cerebrospinal fluid NOx (nitrite/nitrate) in RSV-infected children with CNS symptoms

Morıchı, Shinichiro; Kawashima, Hisashi; Ioi, Hiroaki; Ushio, Masanobu; Yamanaka, Gaku; Kashiwagi, Yasuyo; Takekuma, Kouji; Hoshika, Akinori; Watanabe, Yasuo

doi:10.1016/j.jinf.2009.07.008

Cited by 16 publications

(12 citation statements)

References 7 publications

(1 reference statement)

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“…Abnormal CSF findings such as elevated protein levels, increased cell number, or decreased glucose concentrations have been observed in approximately 50% of patients with no apparent neurological complications, suggesting a frequent subclinical involvement of the central nervous system 4 . The RSV genome was detected in the CSF in several cases of RSV‐associated encephalopathy, suggesting the direct invasion of RSV to the central nervous system 8,9 …”

Section: Discussionmentioning

confidence: 99%

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Respiratory syncytial virus‐associated encephalopathy complicated by congenital myopathy

Nakamura

Kato

Sasaki

et al. 2012

Pediatrics International

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A 23-month-old Japanese girl with a severe form of congenital fiber type disproportion myopathy under mechanical ventilation suffered from respiratory syncytial virus (RSV) bronchiolitis, complicated with acute encephalopathy. She showed consciousness disturbance and convulsions followed by severe brain damage, a rare complication in RSV infection. Patients with severe neuromuscular diseases are vulnerable to RSV infection. Prophylactic interventions should be recommended.

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Section: Discussionmentioning

confidence: 99%

“…4 The RSV genome was detected in the CSF in several cases of RSV-associated encephalopathy, suggesting the direct invasion of RSV to the central nervous system. 8,9 The short-term prognosis of neurological complications associated with RSV bronchiolitis is usually favorable. Examinations by neuroimaging show no abnormal findings in most cases.…”

Section: Figmentioning

confidence: 99%

Respiratory syncytial virus‐associated encephalopathy complicated by congenital myopathy

Nakamura

Kato

Sasaki

et al. 2012

Pediatrics International

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“…Studies have shown that patients admitted to the hospital with bacterial meningitis and influenza-associated encephalopathy had higher levels of CSF NOx as compared to controls [45]. In another study, patients with RSV infection and symptoms of encephalitis, encephalopathy or seizures were found to have a higher concentration of CSF NOx compared with those with influenza positive encephalopathy or those without meningitis [46]. Neither were the studies set up in the ED nor did they analyze CSF NOx in meningitis from different pathogens in the same setting.…”

Section: No and Its Metabolites In Acute Disease Processesmentioning

confidence: 99%

Nitric Oxide and its Metabolites in the Critical Phase of Illness: Rapid Biomarkers in the Making

Mian

Aranke²,

Bryan

2013

Open Biochem J

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The potential of nitric oxide (NO) as a rapid assay biomarker, one that could provide a quantum leap in acute care, remains largely untapped. NO plays a crucial role as bronchodilator, vasodilator and inflammatory mediator. The main objective of this review is to demonstrate how NO is a molecule of heavy interest in various acute disease states along the emergency department and critical care spectrum: respiratory infections, central nervous system infections, asthma, acute kidney injury, sepsis, septic shock, and myocardial ischemia, to name just a few. We discuss how NO and its oxidative metabolites, nitrite and nitrate, are readily detectable in several body compartments and fluids, and as such they are associated with many of the pathophysiological processes mentioned above. With methods such as high performance liquid chromatography and chemiluminescence these entities are relatively easy and inexpensive to analyze. Emphasis is placed on diagnostic rapidity, as this relates directly to quality of care in acute care situations. Further, a rationale is provided for more bench, translational and clinical research in the field of NO biomarkers for such settings. Developing standard protocols for the aforementioned disease states, centered on concentrations of NO and its metabolites, can prove to revolutionize diagnostics and prognostication along a spectrum of clinical care. We present a strong case for developing these biomarkers more as point-of-care assays with potential of color gradient test strips for rapid screening of disease entities in acute care and beyond. This will be relevant to global health.

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“…Prolonged seizure triggers excitotoxicity, and an excessive release of glutamate leads to apoptotic cell death due to increased intracellular calcium . Elevated cytokines in the CSF of RSV encephalopathy patients has been reported, suggesting that interleukin‐6, tumor necrosis factor‐α, soluble tumor necrosis factor receptor 1, and nitrogen oxides (NOx) in the central nervous system damaged astrocytes and oligodendrocytes and triggered neuronal apoptosis …”

Section: Discussionmentioning

confidence: 99%

Febrile status epilepticus due to respiratory syncytial virus infection

Uda

Kitazawa

2017

Pediatrics International

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Cerebrospinal fluid NOx (nitrite/nitrate) in RSV-infected children with CNS symptoms

Cited by 16 publications

References 7 publications

Respiratory syncytial virus‐associated encephalopathy complicated by congenital myopathy

Respiratory syncytial virus‐associated encephalopathy complicated by congenital myopathy

Nitric Oxide and its Metabolites in the Critical Phase of Illness: Rapid Biomarkers in the Making

Febrile status epilepticus due to respiratory syncytial virus infection

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