Cerebrospinal fluid metabolomes of treatment-resistant depression subtypes and ketamine response: a pilot study
Jon Berner,
Animesh Acharjee
Abstract:Depression is a disorder with variable presentation. Selecting treatments and dose-finding is, therefore, challenging and time-consuming. In addition, novel antidepressants such as ketamine have sparse optimization evidence. Insights obtained from metabolomics may improve the management of patients. The objective of this study was to determine whether compounds in the cerebrospinal fluid (CSF) metabolome correlate with scores on questionnaires and response to medication. We performed a retrospective pilot stud… Show more
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