Cerebrospinal fluid leucocyte counts in healthy neonates

Martı́n-Ancel, Ana; García‐Alix, Alfredo; Salas, Sofía P; Castillo, FD; Cabañas, Fernando; Quero, J

doi:10.1136/adc.2005.082826

Cited by 29 publications

(25 citation statements)

References 8 publications

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“…The initial search term was “cerebrospinal fluid,” which was then combined with “white blood cell” or “leukocytosis,” and either “neonate,” “infant” or “newborn.” Limits included “humans” and “English language.” Titles and abstracts of 300 articles were reviewed for relevance: 5 studies were found to be relevant 17, 21, 23, 25, 27. Nine additional studies were identified during review of the references of textbooks and published studies 14–16, 18–20, 22, 24, 26…”

Section: Methodsmentioning

confidence: 99%

Defining Cerebrospinal Fluid White Blood Cell Count Reference Values in Neonates and Young Infants

et al. 2010

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Section: Methodsmentioning

confidence: 99%

Defining Cerebrospinal Fluid White Blood Cell Count Reference Values in Neonates and Young Infants

et al. 2010

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“…In studies that have excluded infants with "traumatic taps" (or nonbacterial illnesses), the mean number of white blood cells in uninfected preterm or term infants was consistently <10 cells/mm 3 . [44][45][46][47][48][49][50] Cell counts 2 standard deviations from the mean were generally less than 20 cells/mm 3 . 46 In a study by Garges et al, the median number of white blood cells in infants who were born at greater than 34 weeks' gestation and had bacterial meningitis was 477/mm 3 .…”

Section: Lumbar Puncturementioning

confidence: 99%

“…55 Protein concentrations in uninfected, term newborn infants are <100 mg/ dL. [44][45][46][47][48][49][50] Preterm infants have CSF protein concentrations that vary inversely with gestational age. In the normoglycemic newborn infant, glucose concentrations in CSF are similar to those in older infants and children (70%-80% of a simultaneously obtained blood specimen).…”

Section: Lumbar Puncturementioning

confidence: 99%

Management of Neonates With Suspected or Proven Early-Onset Bacterial Sepsis

Polin¹,

Newborn²

2012

Pediatrics

684

433

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With improved obstetrical management and evidence-based use of intrapartum antimicrobial therapy, early-onset neonatal sepsis is becoming less frequent. However, early-onset sepsis remains one of the most common causes of neonatal morbidity and mortality in the preterm population. The identification of neonates at risk for early-onset sepsis is frequently based on a constellation of perinatal risk factors that are neither sensitive nor specific. Furthermore, diagnostic tests for neonatal sepsis have a poor positive predictive accuracy. As a result, clinicians often treat well-appearing infants for extended periods of time, even when bacterial cultures are negative. The optimal treatment of infants with suspected early-onset sepsis is broad-spectrum antimicrobial agents (ampicillin and an aminoglycoside). Once a pathogen is identified, antimicrobial therapy should be narrowed (unless synergism is needed). Recent data suggest an association between prolonged empirical treatment of preterm infants (≥5 days) with broad-spectrum antibiotics and higher risks of late onset sepsis, necrotizing enterocolitis, and mortality. To reduce these risks, antimicrobial therapy should be discontinued at 48 hours in clinical situations in which the probability of sepsis is low. The purpose of this clinical report is to provide a practical and, when possible, evidence-based approach to the management of infants with suspected or proven early-onset sepsis. Pediatrics

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“…However, mild pleocytosis can be observed in symptomatic infants without CNS infection. Lack of CSF pleocytosis can represent a prognostic factor (17). In the patient reported here, rifampin plus vancomycin did not cause major changes in the activity of either drug alone, but it was more effective than ceftriaxone.…”

Section: Discussionmentioning

confidence: 52%

A Rare Case of Pneumococcal and Meningococcal Mixed Meningitis in an Infant with Cardiac Dysfunction

Shayestehpour

Romani

Namin

et al. 2018

Arch Clin Infect Dis

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Meningitis is commonly caused by a viral, bacterial, fungal, or parasitic infection that involves the cerebrospinal fluid (CSF) and leads to inflammation of the protective membranes covering the brain and spinal cord. Among bacterial pathogens responsible for meningitis, Streptococcus pneumoniae is notorious for causing more than 50% of all cases of bacterial meningitis. Neisseria meningitis is also a major cause of bacterial meningitis. Here, we report a rare case of a 13-month-old infant with cardiac dysfunction associated with meningitis caused by co-infection with Streptococcus pneumoniae and Neisseria meningitides. Cardiac dysfunction is a condition where the heart pumping becomes less effective and the heart cannot pump sufficient blood to meet the body's needs. Bacteria were isolated by culture and detected by polymerase chain reaction (PCR) on CSF. The patient was treated with vancomycin, ceftriaxone, and rifampin followed by three months of follow-up without any clinical symptoms. This raises the possibility of finding other cases of mixed neonatal meningitis in the future since the incidence of meningitis is currently increasing in the region.

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Cerebrospinal fluid leucocyte counts in healthy neonates

Cited by 29 publications

References 8 publications

Defining Cerebrospinal Fluid White Blood Cell Count Reference Values in Neonates and Young Infants

Defining Cerebrospinal Fluid White Blood Cell Count Reference Values in Neonates and Young Infants

Management of Neonates With Suspected or Proven Early-Onset Bacterial Sepsis

A Rare Case of Pneumococcal and Meningococcal Mixed Meningitis in an Infant with Cardiac Dysfunction

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