Cerebrospinal Fluid Lactic Acid Level and pH in Meningitis

Bland, Richard D.; Lister, Robert C.; Ries, John P.

doi:10.1001/archpedi.1974.02110270025006

Cited by 93 publications

(31 citation statements)

References 28 publications

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“…High concentrations of CSF lactate have been found in patients with BM despite a low neutrophil count [32]. This clinical observation has also been made in experimental BM where high levels of CSF lactate were documented in neutropenic and normal control animals, independent of the presence of neutrophils in CSF [21].…”

Section: Discussionsupporting

confidence: 53%

Predictive Value of Cerebrospinal Fluid (CSF) Lactate Level Versus CSF/Blood Glucose Ratio for the Diagnosis of Bacterial Meningitis Following Neurosurgery

Leib¹,

Boscacci²,

Gratzl³

et al. 1999

CLIN INFECT DIS

150

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The value of cerebrospinal fluid (CSF) lactate level and CSF/blood glucose ratio for the identification of bacterial meningitis following neurosurgery was assessed in a retrospective study. During a 3-year period, 73 patients fulfilled the inclusion criteria and could be grouped by preset criteria in one of three categories: proven bacterial meningitis (n ‫؍‬ 12), presumed bacterial meningitis (n ‫؍‬ 14), and nonbacterial meningeal syndrome (n ‫؍‬ 47).

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Section: Discussionsupporting

confidence: 53%

Predictive Value of Cerebrospinal Fluid (CSF) Lactate Level Versus CSF/Blood Glucose Ratio for the Diagnosis of Bacterial Meningitis Following Neurosurgery

Leib¹,

Boscacci²,

Gratzl³

et al. 1999

CLIN INFECT DIS

150

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show abstract

“…The cerebrospinal fluid (CSF) plays a major role in the evaluation of the natural history, in the diagnosis and in the follow-up of the infectious and inflammatory pathologies of the CNS [1][2][3] . In many cases, the routine evaluation of the CSF is not sufficient for diagnosing the type of meningitis [4][5][6] .…”

mentioning

confidence: 99%

Dosage of lactate in the cerebrospinal fluid in infectious diseases of the central nervous system

Cabeça

Gomes

Machado

et al. 2001

Arq. Neuro-Psiquiatr.

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-This paper analyzes the diagnosis aid of the dosage of lactate in the cerebrospinal fluid (CSF) in infectious diseases of the central nervous system (CNS). We analyzed prospectively 130 samples of CSF of 116 patients with diagnoses of infectious processes in the CNS. The 130 samples of CSF were divided into five groups: 28 samples of the control group, 40 of bacterial meningitis, 22 of viral meningitis, 16 of fungal meningitis and 24 of patients presenting acquired immune deficiency syndrome (AIDS). The concentration of lactate in the CSF was elevated in the group of patients with bacterial meningitis (average = 46.2 mg/dL), fungal meningitis (average = 27.3 mg/dL) and in the AIDS group (average = 23.5 mg/dL). In the control group and viral meningitis group the lactate content in the CSF presented the reference rates according to the employed method. The lactate dosage in the CSF presented a negative correlation with glycorrhachia and positive correlation with the cellularity and total proteins of the CSF. We conclude that the lactate dosage in the CSF, although unspecific, helps to distinguish the infectious processes of the CNS.KEY WORDS: lactate, cerebrospinal fluid, central nervous infections. Dosagem de lactato no líquido cefalorraqueano em moléstias infecciosas do sistema nervoso central RESUMO -O presente estudo tem como objetivo analisar o auxílio diagnóstico da dosagem do lactato no líquido cefalorraqueano (LCR) em moléstias infecciosas do sistema nervoso central (SNC). Foram estudadas, de modo prospectivo, 130 amostras de LCR de 116 pacientes com diagnóstico de processos infecciosos do SNC. As 130 amostras de LCR foram distribuídas em cinco grupos, sendo: 28 amostras controles, 40 meningite bacteriana, 22 meningite viral, 16 meningite fúngica e 24 pacientes com a síndrome da imunodeficiência humana adquirida (SIDA). A concentração do lactato no LCR estava elevada no grupo de pacientes com meningite bacteriana (média=46,20 mg/dL), meningite fúngica (média=27,37 mg/dL) e no grupo SIDA (média=23,54 mg/dL). Nos grupos controle e de meningite viral o teor de lactato no LCR encontrava-se entre os valores de referência para o método utilizado. A dosagem do lactato no LCR apresentou correlação negativa com a glicorraquia, e positiva com a celularidade e proteínas totais do LCR. Em conclusão, a dosagem do lactato no LCR, apesar de inespecífica, auxilia na distinção entre processos infecciosos do SNC. PALAVRAS-CHAVE: ácido láctico, líquido cefalorraqueano, infecções do sistema nervoso central.

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“…The lactic acid levels in all nine patients with aseptic meningitis were slightly above the uninfected controls; (22.6±6.1 mg/dl) but was not diagnostic. The lactic acid levels remained higher than normal for at least 3 meningitis. In addition to lactic acid and succinic acid, four other minor unidentified peaks were also found, but they were not considered diagnostic.…”

Section: Methodsmentioning

confidence: 88%

“…Lactic acid levels in CSF are increased in cases of purulent bacterial meningitis (3)(4)(5). Leukocyte lactate dehydrogenase activity (6,7) and lysozyme levels increase in bacterial, but not in viral meningitis (8)(9)(10).…”

mentioning

confidence: 99%

Rapid differentiation of bacterial meningitides by direct gas-liquid chromatography.

Thadepalli¹,

Gangopadhyay²,

Ansari³

et al. 1982

J. Clin. Invest.

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Cerebrospinal Fluid Lactic Acid Level and pH in Meningitis

Cited by 93 publications

References 28 publications

Predictive Value of Cerebrospinal Fluid (CSF) Lactate Level Versus CSF/Blood Glucose Ratio for the Diagnosis of Bacterial Meningitis Following Neurosurgery

Predictive Value of Cerebrospinal Fluid (CSF) Lactate Level Versus CSF/Blood Glucose Ratio for the Diagnosis of Bacterial Meningitis Following Neurosurgery

Dosage of lactate in the cerebrospinal fluid in infectious diseases of the central nervous system

Rapid differentiation of bacterial meningitides by direct gas-liquid chromatography.

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