Cerebrospinal fluid interleukin 8 concentrations and the subsequent development of postherpetic neuralgia

Kotani, Naoki; Kudo, Ryoko; Sakurai, Yutaka; Sawamura, Daisuke; Sessler, Daniel I.; Okada, Hiroshi; Nakayama, Hiromichi; Yamagata, Toshifumi; Yasujima, Minoru; Matsuki, Akitomo

doi:10.1016/j.amjmed.2003.10.027

Cited by 53 publications

(35 citation statements)

References 27 publications

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“…Elevated CSF pro-inflammatory cytokine levels indicative of excessive neuroinflammation are thought to be associated with chronic pain states, and have been reported in patients with chronic nociceptive (Lundborg et al, 2010;Backonja et al, 2008;Bjurstrom et al, 2016) as well as neuropathic pain (Kotani et al, 2004). Besides signs of neuroinflammation as reflected by CSF cytokine indices, brain positron emission tomography (PET) scans of patients with chronic back pain show microglial cell specific activation (greater than healthy controls) in: 1) medial thalamic, 2) post central gyrus, and 3) paracentral lobule, suggesting that chronic pain mediated neuroinflammation and central sensitization likely co-occur in both the brain and spinal cord (Loggia et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Posttraumatic stress disorder influences the nociceptive and intrathecal cytokine response to a painful stimulus in combat veterans

Lerman

Davis

Bertram

et al. 2016

Psychoneuroendocrinology

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a b s t r a c tObjective: Although posttraumatic stress disorder (PTSD) and chronic pain frequently occur in tandem, the pathophysiological mechanisms mediating this comorbidity are poorly understood. Because excessive inflammation occurs in both conditions, we examined the cerebrospinal fluid (CSF) concentrations of inflammatory response mediators interleukin 1-beta (IL-1␤), interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor-alpha (TNF␣) and interleukin 10 (IL-10) after prolonged suprathreshold pain stimulus in 21 male combat veterans; 10 with PTSD and 11 combat controls (CC). Methods: After completing baseline quantitative sensory testing (QST) and psychological profiling, all patients received an injection of capsaicin into the quadriceps muscle. Spontaneously reported pain was measured for 30 min after the capsaicin injection. The evoked pain measure of temporal summation was tested between 70 and 110 min post capsaicin injection. Inflammatory (IL-1␤, IL-6, IL-8 TNF␣) and antiinflammatory (IL-10) CSF cytokines were measured before (baseline) and after capsaicin injection over a time frame of 110 min. Results: Following intramuscular capsaicin injection, pro-inflammatory cytokines [TNF␣, IL-6, IL-8] significantly increased (percent rise from baseline) in both groups, whereas IL-1␤ significantly increased in the PTSD group only. The anti-inflammatory cytokine IL-10 showed an immediate (within 10 min) increase in the CC group; however, the IL-10 increase in the PTSD group was delayed and not consistently elevated until 70 min post injection. Conclusion: These findings show significant central nervous system (CNS) differences in the inflammatory response to a deep pain stimulus in combat veterans with and without PTSD. They support the concept that abnormally elevated neuroinflammatory response to pain stimuli may be one CNS mechanism accounting for the high co-occurrence of PTSD and pain.Published by Elsevier Ltd.

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Section: Discussionmentioning

confidence: 99%

Posttraumatic stress disorder influences the nociceptive and intrathecal cytokine response to a painful stimulus in combat veterans

Lerman

Davis

Bertram

et al. 2016

Psychoneuroendocrinology

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“…Although the exact molecular mechanism by which cytokines influence pain has not been fully elucidated, studies suggest that cytokines released during inflammation or tissue damage (as in the cancer process) modify the activity of nociceptors contributing to pain hypersensitivity. Clinical studies show elevated IL-8 levels in patients with chronic pain conditions such back pain (33), post-herpetic neuralgia (34), and unstable angina (35). In animal studies, Cunha et al (36) measured the hyperalgesic effect of IL8 in a rat paw pressure test and found that IL-8 evoked dose-dependent hyperalgesia.…”

Section: Discussionmentioning

confidence: 99%

Cytokine Genes and Pain Severity in Lung Cancer: Exploring the Influence of TNF-α-308 G/A IL6-174G/C and IL8-251T/A

Reyes‐Gibby¹,

Spitz²,

Wu³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Introduction: Cytokines, aberrantly produced by cancer cells, have recently been implicated in the severity of cancer-related pain. We explored if polymorphisms in candidate cytokine genes could explain variability in self-reported pain in lung cancer patients of all stages. Methods: Pain, clinical, and demographic variables were assessed at presentation and before any cancer treatment in 446 Whites, 125 African-Americans, and 35 Hispanics with newly diagnosed non -small cell lung cancer. We genotyped functional single nucleotide polymorphisms in tumor necrosis factor-A (TNF-a -308 G/A), interleukin-6 (IL-6) -174G/C, and IL-8 -251T/A and determined their associations with pain severity. Results: More African-Americans (35.5%) reported severe pain (score z7 on a 0-10 scale) relative to Hispanics (20%) and Whites (17%; P < 0.001). We did not observe any significant association between geno-

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“…However, the observation that cytokines are capable of inducing pruritus or that cytokine inhibitors exert analgesic capacity even before showing clinically substantial anti-inflammatory effects led to the hypothesis that cytokines may contribute to neurogenic inflammation, pain, and pruritus. Moreover, a cross-talk between neuropeptide receptors with chemokine receptors has recently been proposed as an important link of the neuroimmune axis in the regulation of inflammation and immunity (245, 451,486,896,934,958).…”

Section: Cytokines and Chemokines As Ligands For Skin Sensory Nmentioning

confidence: 99%

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman¹,

Goerge

Schneider

et al. 2006

Physiological Reviews

552

521

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This review focuses on the role of the peripheral nervous system in cutaneous biology and disease. During the last few years, a modern concept of an interactive network between cutaneous nerves, the neuroendocrine axis, and the immune system has been established. We learned that neurocutaneous interactions influence a variety of physiological and pathophysiological functions, including cell growth, immunity, inflammation, pruritus, and wound healing. This interaction is mediated by primary afferent as well as autonomic nerves, which release neuromediators and activate specific receptors on many target cells in the skin. A dense network of sensory nerves releases neuropeptides, thereby modulating inflammation, cell growth, and the immune responses in the skin. Neurotrophic factors, in addition to regulating nerve growth, participate in many properties of skin function. The skin expresses a variety of neurohormone receptors coupled to heterotrimeric G proteins that are tightly involved in skin homeostasis and inflammation. This neurohormone-receptor interaction is modulated by endopeptidases, which are able to terminate neuropeptide-induced inflammatory or immune responses. Neuronal proteinase-activated receptors or transient receptor potential ion channels are recently described receptors that may have been important in regulating neurogenic inflammation, pain, and pruritus. Together, a close multidirectional interaction between neuromediators, high-affinity receptors, and regulatory proteases is critically involved to maintain tissue integrity and regulate inflammatory responses in the skin. A deeper understanding of cutaneous neuroimmunoendocrinology may help to develop new strategies for the treatment of several skin diseases.

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Cerebrospinal fluid interleukin 8 concentrations and the subsequent development of postherpetic neuralgia

Cited by 53 publications

References 27 publications

Posttraumatic stress disorder influences the nociceptive and intrathecal cytokine response to a painful stimulus in combat veterans

Posttraumatic stress disorder influences the nociceptive and intrathecal cytokine response to a painful stimulus in combat veterans

Cytokine Genes and Pain Severity in Lung Cancer: Exploring the Influence of TNF-α-308 G/A IL6-174G/C and IL8-251T/A

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

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