Cerebrospinal fluid immune complexes in multiple sclerosis

Deicher, H.; Schwabedissen, H. Meyer zu; Baruth, B.; Patzold, U; Haller, P

doi:10.1007/bf01963318

Cited by 21 publications

(5 citation statements)

References 3 publications

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“…These observations have stimulated research on the pattern of circulating IC in MS. Some early reports (12)(13)(14)(15)(16)(17) dealt with only one IC assay, whereas more recently (18)(19)(20)(21) results have been obtained by different assays, as suggested by WHO. A correlation has been demonstrated between IC levels and the clinical course of the disease (13,16,17,20), and a relationship suggested with such other biological changes as barrier damage (12), lymphocyte population modifications (14), increased CSF T cells, and decreased T suppressor activity (20).…”

mentioning

confidence: 99%

Circulating immune complexes in serum and in cerebrospinal fluid of patients with multiple sclerosis

Procaccia¹,

Lanzanova²,

Caputo

et al. 1988

Acta Neurologica Scandinavica

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We studied circulating immune complexes (IC) in the serum and cerebrospinal fluid (CSF) of patients with clinically defined multiple sclerosis (MS), in order to establish a correlation with the clinical course of the disease and to investigate the molecular composition of the IC isolated from patients in active phase of the disease. Serum IC levels were found to be significantly increased in patients from the progressive and active relapsing-remittent subgroups with both the CIC-conglutinin and C1q-binding methods. High levels of IC in CSF were detected only in the subgroup consisting of the relapsing-remittent patients in disease exacerbation when IC were determined by the C1q-binding test. No significant increase in serum or in CSF were found using the mRF-I test. The preliminary results of a qualitative investigation on serum IC in MS indicated that they are heterogeneous in nature, their size is mainly of the intermediate type, and they contain IgG, IgM, complement components and beta 2-microglobulins, the latter presenting an observation both new and interesting for studies on serum IC in MS patients.

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mentioning

confidence: 99%

Circulating immune complexes in serum and in cerebrospinal fluid of patients with multiple sclerosis

Procaccia¹,

Lanzanova²,

Caputo

et al. 1988

Acta Neurologica Scandinavica

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“…Ob es sich hierbei um gewebsgebundene oder zirkulierende Immunkomplexe handelt, wird nicht näher präzisiert. Nach dem heutigen Wissensstand besteht kein Zweifel, daß bei der MS sowohl im Gehirn (Tavolato 1975) als auch im Serum (Tachovsky et al 1976) und Liquor (Deicher et al 1979 Immunkomplexe auftreten. Patzold et al (1980) fanden im Serum von 138 MS-Kranken in 46 Fällen zirkulierende Immunkomplexe und in 124 Liquorproben fiel der Nachweis 24mal positiv aus.…”

Section: Kasuistikunclassified

Anaphylaktische Reaktion unter Enzymtherapie bei multipler Sklerose

Wr¹

1987

Fortschr Neurol Psychiatr

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“…Multiple sclerosis (MS) seems associated with both the appearence of circulating immune complexes (CIC) (1, 2, 3, 4, 5, 6, 7, 8, 9, lo), and, to a certain extent, with the occurrence of immune complexes (IC) in cerebrospinal fluid (CSF) (10,11,12,13,14). Furthermore, possible relationships between the occurrence of CIC, variations in the complement levels in serum and the activ-ity or manifestations of the disease have been suggested (6,12,15,16,17,18,19).…”

Section: Accepted For Publication September 28 I983mentioning

confidence: 99%

Immune complexes and the complement factors C4 and C3 in cerebrospinal fluid and serum from patients with chronic progressive multiple sclerosis

Jans

Heltberg

Zeeberg

et al. 1984

Acta Neurologica Scandinavica

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Immune complexes (IC) have been found in both serum and cerebrospinal fluid (CSF) in multiple sclerosis (MS). The complement system is known to play a major role as a mediator of inflammation in immune complex disease. Therefore, we have investigated paired samples of serum and CSF from 32 patients with progressive MS for IC, the levels of the complement factors C4 and C3, and presence of their activation products (AP). IC was found in serum from 17 of the 32 MS patients (53%) and in CSF from 9 of 31 MS patients (29%). No correlation was found between the occurrence of IC in serum and in CSF. The levels of C3 in serum and CSF from the MS patients did not differ from the levels in a control group, whereas the levels of C4 in MS-serum were elevated and the C4 levels in MS-CSF reduced. A low level of CSF-C4 correlated significantly to the occurrence of CSF-IC. AP of C4 and C3 in serum were seen in 11 of the 32 patients (34%), appearing significantly more frequently among patients with circulating IC. No C4- or C3AP could be identified in CSF.

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Cerebrospinal fluid immune complexes in multiple sclerosis

Abstract: Using a C1q binding test, immune complexes have been detected in one half of cerebrospinal fluid samples from patients with multiple sclerosis. These results provide additional evidence for the participation of an immune reaction in the disease process.

Cited by 21 publications

References 3 publications

Circulating immune complexes in serum and in cerebrospinal fluid of patients with multiple sclerosis

Circulating immune complexes in serum and in cerebrospinal fluid of patients with multiple sclerosis

Anaphylaktische Reaktion unter Enzymtherapie bei multipler Sklerose

Immune complexes and the complement factors C4 and C3 in cerebrospinal fluid and serum from patients with chronic progressive multiple sclerosis

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