Cerebrospinal fluid filtration in Guillain–Barré syndrome

Urwin, S. C.; Hunt, P. S.

doi:10.1046/j.1365-2044.2000.01425-24.x

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…CSF can also serve as a conduit for drug delivery to the brain, as solutes delivered to the CSF bypass the blood brain barrier thereby providing relatively direct access to neuronal and glial cells [12,13]. CSF-based therapeutics are presently under development for brain hypothermia [14], CSF filtration [15][16][17][18], and control of intracranial CSF pressure oscillations [19].…”

Section: Introductionmentioning

confidence: 99%

Anthropomorphic Model of Intrathecal Cerebrospinal Fluid Dynamics Within the Spinal Subarachnoid Space: Spinal Cord Nerve Roots Increase Steady-Streaming

Khani

Sass

Xing

et al. 2018

Journal of Biomechanical Engineering

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Cerebrospinal fluid (CSF) dynamics are thought to play a vital role in central nervous system (CNS) physiology. The objective of this study was to investigate the impact of spinal cord (SC) nerve roots (NR) on CSF dynamics. A subject-specific computational fluid dynamics (CFD) model of the complete spinal subarachnoid space (SSS) with and without anatomically realistic NR and nonuniform moving dura wall deformation was constructed. This CFD model allowed detailed investigation of the impact of NR on CSF velocities that is not possible in vivo using magnetic resonance imaging (MRI) or other noninvasive imaging methods. Results showed that NR altered CSF dynamics in terms of velocity field, steady-streaming, and vortical structures. Vortices occurred in the cervical spine around NR during CSF flow reversal. The magnitude of steady-streaming CSF flow increased with NR, in particular within the cervical spine. This increase was located axially upstream and downstream of NR due to the interface of adjacent vortices that formed around NR.

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