Cerebrospinal fluid ferritin in malignant CNS involvement

Zandman‐Goddard, Gisele; Matzner, Yaacov; Konijn, Abraham M.; Hershko, Chaim

doi:10.1002/1097-0142(19860915)58:6<1346::aid-cncr2820580627>3.0.co;2-w

Cited by 22 publications

(9 citation statements)

References 23 publications

(18 reference statements)

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“…In this study CSF ferritin measurement seems to be not useful in the differential diagnosis of malignant CNS involvement and CNS inflammation because in both conditions CSF ferritin levels are increased confirming the results of previous studies 8,9 . Also, CSF ferritin was higher in the group with bacterial meningitis than the other groups, in accordance with previous papers 10 .…”

supporting

confidence: 81%

“…CSF ferritin levels were higher at the group with CNS malignant involvement proved by the presence of malignant cells in CSF, than in the group with inflammatory CNS diseases. The number of erythrocytes (rBC) in CSF correlates with CSF ferritin levels 9,10,25 , because of this we excluded the CSF samples with more than 50 rBC/mm 3 …”

Section: Discussionmentioning

confidence: 99%

“…Ferritin is present at very low concentrations in normal CSF. Previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion on the CNS than in patients without CNS involvement [7][8][9] . high values of ferritin were also found in non-malignant diseases, such as infectious meningoencephalitis, CNS vascular diseases, and dementia 10 .…”

mentioning

confidence: 99%

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Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration

Almeida

Cunha

Yamada

et al. 2008

Arq. Neuro-Psiquiatr.

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-Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a biomarker for the diagnosis of CNS neoplasic infiltration. This study is based on 93 CSF samples, divided into five groups: malignant cells present (n13); malignant cells not present (n26); inflammatory neurological diseases (n16); neurocysticercosis (n20); acute bacterial meningitis (n18). CSF ferritin values were determined by micro particle enzyme immunoassay. CSF ferritin level (mean±SD) in the group with neoplasic cells in the CSF was 42.8±49.7 ng /mL, higher than in the other groups (p<0.0001). We conclude that CSF ferritin with the cut off 20 ng/mL could be an adjuvant biomarker to the diagnosis of CNS malignant infiltration.Key WorDS: cerebrospinal fluid, ferritin, central nervous system, malignant cells, CNS neoplasm, CNS tumors, bacterial meningitis. Quantificação de ferritina no líquido cefalorraquidiano como biomarcador para o diagnóstico de infiltração maligna no sncResumo -Diversos marcadores foram estudados com a finalidade de avaliar sua capacidade de diagnosticar a infiltração neoplásica no SNC precocemente e de forma mais precisa. estudos anteriores mostraram que as concentrações de ferritina no LCr eram mais elevadas nos pacientes com infiltração neoplásica no SNC. o objetivo foi determinar a importância da ferritina no LCr como biomarcador para o diagnóstico de infiltração neoplásica no SNC. este estudo é baseado em 93 amostras do LCr, divididas em cinco grupos: células malignas presentes (n13); células malignas ausentes (n26); doenças neurologicas inflamatórias (n16); neurocisticercose (n20); meningites bacterianas agudas (n18). os valores de ferritina no LCr foram determinados por eLISA de microparticulas. o nível de ferritina no LCr (média±desvio padrão) no grupo com células neoplásicas no LCr foi 42,8±49,7 ng/mL, mais elevado do que nos outros grupos (p<0.0001). Concluímos que a ferritina no LCr com cut off de 20 ng/mL pode ser um biomarcador para o diagnóstico de infiltração maligna no SNC.PALAvrAS-ChAve: líquido cefalorraquidiano, sistema nervoso central, células malignas, neoplasias do SNC, tumores do SNC, meningites bacterianas.

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supporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration

Almeida

Cunha

Yamada

et al. 2008

Arq. Neuro-Psiquiatr.

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“…9 High CSF concentrations of iron and ferritin are also seen in malignant and inflammatory conditions of the CNS. 13…”

Section: Discussionmentioning

confidence: 99%

“…9 High CSF concentrations of iron and ferritin are also seen in malignant and inflammatory conditions of the CNS. 13 Superficial siderosis remains a rare disease. Since the original report in 1908, only 270 cases have been reported in 99 y between 1908 and 2006.…”

Section: Brain Cells Iron -Storagementioning

confidence: 99%

Superficial siderosis – mechanism of disease: an alternative hypothesis

2010

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Superficial siderosis is an increasingly common diagnosis due to advances in imaging. Resulting from the presence of blood in the subarachnoid space, it leads to progressively debilitating ataxia, deafness and myelopathy. Magnetic resonance imaging has revolutionized diagnosis and management of this condition. In one-third of patients with this diagnosis, no subarachnoid bleed can be identified. A lack of sensitivity in our ability to detect subarachnoid bleed is a possible explanation in this group of patients. A novel approach would be to consider defects in the body's defense against intracranial iron overload as a possible cause of this disease. A disproportionately few patients develop superficial siderosis compared with the number who develop subarachnoid bleed from various clinical conditions. Normal physiological protective mechanisms exist in the central nervous system to protect it from damage by blood, haeme or free iron. Deficiency and defect of these protective mechanisms can provide insight into the pathogenetic mechanism of the group of patients where no subarachnoid haemorrhage is identified.

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Diagnostic value of ferritin in malignant pleural and peritoneal effusions

Yinnon

Konijn

Link

et al. 1988

Cancer

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The diagnostic usefulness of ferritin measurements in pleural and peritoneal effusions has been evaluated in 57 patients. Mean (+/- standard error [SE]) ferritin levels were 291 +/- 50 ng/ml in 24 patients with noninflammatory transudates (Group I), 942 +/- 253 in 15 patients with nonmalignant exudates (Group II), and 1805 +/- 257 in 18 patients with malignant exudates (Group III). The mean (+/- SE) ratio of effusion/serum ferritin in Groups I, II, and III was 0.7 +/- 0.1, 2.7 +/- 0.7, and 5.7 +/- 1.2, respectively. The specificity and predictive value of a ferritin ratio in excess of 1.5 in distinguishing transudates from all exudates and in distinguishing transudates from malignant exudates were both very high (94%) to 96%). In the lower range of values considerable overlap existed between ferritin ratios obtained in patients with benign versus malignant inflammatory exudates. However, very high ferritin levels (greater than 3000 ng/ml) and ferritin ratios (greater than 20:1) were only encountered in malignant exudates. These results indicate that the measurement of ferritin levels and ferritin ratios may be a useful aid in the diagnosis of malignant pleural and peritoneal effusions.

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Cerebrospinal fluid ferritin in malignant CNS involvement

Cited by 22 publications

References 23 publications

Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration

Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration

Superficial siderosis – mechanism of disease: an alternative hypothesis

Diagnostic value of ferritin in malignant pleural and peritoneal effusions

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