Cerebrospinal Fluid Enzymes in Neurological Disease

Banik, Naren L.; Hogan, Edward L.

doi:10.1007/978-1-4615-9269-3_15

Cited by 9 publications

(5 citation statements)

References 217 publications

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“…The CSF concentration of trypsin and other proteases, as well as peptidases, may increase with disease. 26 Little is known of their effects, or their end products, on cerebral arteries. Also, thrombin is the most potent fibroblast mitogen and, therefore, might be responsible for the meningeal fibrosis and hydrocephalus that follows SAH.…”

Section: Discussionmentioning

confidence: 99%

Vasodilator proteins: role in delayed cerebral vasospasm.

White¹

1986

Stroke

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Blood proteins could play a critical role in the pathogenesis of cerebral vasospasm in subarachnoid hemorrhage (SAH) as agonists and as antagonists of vasoconstriction. The present study was designed primarily to quantify the inhibition produced by antithrombin III of the phasic responses elicited by cumulative doses of KCl, serotonin (5-HT), uridine triphosphate (UTP), and thrombin in isolated canine basilar arteries, and to ascertain whether other proteins might act similarly. Antithrombin III (1 unit/ml and 3 units/ml) given 2 min beforehand inhibited all agonists. The inhibition was not dependent on a functional endothelium nor due to stimulation of the electrogenic sodium pump. Alpha2-macroglobulin (0.1 mg/ml and 0.4 mg/ml) inhibited the contractile responses to high K+, 5-HT and thrombin. Kallikrein (1 and 4 units/ml) did not inhibit UTP but inhibited high K+ and 5-HT through an effect on the endothelium. Kallikrein (1 unit/ml) irreversibly blocked the responses to thrombin. Globulins (3 mg/ml) and fibrinogen (0.3 mg/ml) were not inhibitory. The results demonstrate that anticoagulant proteins are very effective nonspecific inhibitors of the vasoconstriction, whereas the serine protease kallikrein selectively blocks thrombin. The remarkable potency of antithrombin III suggests that it may protect cerebral arteries from exhibiting vasospasm in SAH.

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Section: Discussionmentioning

confidence: 99%

Vasodilator proteins: role in delayed cerebral vasospasm.

White¹

1986

Stroke

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“…A large number of enzymes have been demonstrated to exist in the cerebrospinal fluid by measurement of enzyme activity [3]. The origin of many of these enzymes is outside the nervous system, although specific neurotransmitterrelated enzyme activity is found in the cerebrospinal fluid.…”

Section: Cerebrospinal Fluid Enzymesmentioning

confidence: 99%

Nonimmunoglobulin Proteins in Human Cerebrospinal Fluid

Brooks¹

1989

The Cerebrospinal Fluid

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“…CSF contains a variety of enzymes, and proteinases with different pH optima are among them [12]. CSF contains a variety of enzymes, and proteinases with different pH optima are among them [12].…”

Section: Cerebrospinal Fluid and Peripheral Blood Proteinasesmentioning

confidence: 99%

Proteinases in inflammatory demyelinating disease

Whitaker

1985

Springer Semin Immunopathol

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Cerebrospinal Fluid Enzymes in Neurological Disease

Cited by 9 publications

References 217 publications

Vasodilator proteins: role in delayed cerebral vasospasm.

Vasodilator proteins: role in delayed cerebral vasospasm.

Nonimmunoglobulin Proteins in Human Cerebrospinal Fluid

Proteinases in inflammatory demyelinating disease

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