Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neuronal and oligodendroglial differentiation of human neural precursor cells in vitro

Cristofanilli, Massimiliano; Cymring, Barbara; Lu, Amy; Rosenthal, Hannah E.; Sadiq, Saud

doi:10.1016/j.neuroscience.2013.07.022

Cited by 21 publications

(19 citation statements)

References 39 publications

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“…In the cerebrospinal fluid (CSF) of MS patients, the expression level of cytokines was shown to be upregulated, and direct injection of CSF from MS patients into mouse brain induced demyelination (Cristofanilli et al, 2014). However, in cell culture experiments, CSF from MS patients promoted neuronal and oligodendrocyte differentiation when incubated with neural precursor cells (Cristofanilli et al, 2013). Because it is difficult to isolate the effects of cytokines from other proteins in CSF, no definite conclusion can be drawn from these findings.…”

Section: Factors Affecting Remyelination After Strokementioning

confidence: 99%

Mechanisms of cell–cell interaction in oligodendrogenesis and remyelination after stroke

et al. 2015

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White matter damage is a clinically important aspect of several central nervous system diseases, including stroke. Cerebral white matter primarily consists of axonal bundles ensheathed with myelin secreted by mature oligodendrocytes, which play an important role in neurotransmission between different areas of gray matter. During the acute phase of stroke, damage to oligodendrocytes leads to white matter dysfunction through the loss of myelin. On the contrary, during the chronic phase, white matter components promote an environment, which is favorable for neural repair, vascular remodeling, and remyelination. For effective remyelination to take place, oligodendrocyte precursor cells (OPCs) play critical roles by proliferating and differentiating into mature oligodendrocytes, which help to decrease the burden of axonal injury. Notably, other types of cells contribute to these OPC responses under the ischemic conditions. This mini-review summarizes the non-cell autonomous mechanisms in oligodendrogenesis and remyelination after white matter damage, focusing on how OPCs receive support from their neighboring cells.

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Section: Factors Affecting Remyelination After Strokementioning

confidence: 99%

Mechanisms of cell–cell interaction in oligodendrogenesis and remyelination after stroke

et al. 2015

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“…In addition, we performed these experiments using noncancerous human CSF. The concentrations and presence of trophic factors may differ by disease, therefore, the effects of CSF from disease subtypes remain to be explored [15,16].…”

Section: Figmentioning

confidence: 99%

“…Moreover, it contains large quantities of proteins and trophic factors including insulinlike growth factors (IGFs), bone morphogenetic proteins (BMPs), transforming growth factor-b (TGF-b), and wingless-type MMTV integration site family members (Wnts), which are known to affect the function of stem cells [12][13][14]. Recent experiments showed that human CSF and its contents influence the differentiation and proliferation of NPCs [15][16][17], but the effects of CSF on the viability and mobility of exogenous MSCs and NPCs have yet to be explored. Since stem cell therapy is being investigated for a variety of neurological disorders, it is critical to understand the impact that the CSF can have on exogenous stem cell populations.…”

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confidence: 99%

Human Cerebrospinal Fluid Regulates Proliferation and Migration of Stem Cells Through Insulin-Like Growth Factor-1

Zhu

Feng

Dangelmajer

et al. 2015

Stem Cells and Development

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Mesenchymal stem cells (MSCs) and neural progenitor cells (NPCs) have been regarded for their clinical therapeutic potential for central nervous system (CNS) pathologies. Their potential utility is a result of their intrinsic ability to repair damaged tissues, deliver therapeutic proteins, and migrate to sites of pathology within the brain. However, it remains unclear whether the CNS promotes any changes in these potential therapeutic cells, which would be critical to understand before clinical application. A major component of the CNS is cerebrospinal fluid (CSF). Therefore, the aim of this study was to evaluate the influence that human CSF has on the function of human adipose-derived MSCs (hAMSCs) and human fetal-derived NPCs (hfNPCs) in regard to cell proliferation, survival, and migration. This study demonstrated that human noncancerous CSF promoted proliferation and inhibited apoptosis of hAMSCs and hfNPCs. Preculturing these stem cells in human CSF also increased their migratory speed and distance traveled. Furthermore, insulin-like growth factor-1 (IGF-1) in human CSF enhanced the migration capacity and increased the expression of C-X-C chemokine receptor type 4 (CXCR4) in both stem cell types. These current findings highlight a simple and natural way in which human CSF can enhance the proliferation, migration, and viability of human exogenous primary hAMSCs and hfNPCs. This study may provide insight into improving the clinical efficacy of stem cells for the treatment of CNS pathologies.

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“…These pathological changes were also observed in animal models, such as experimental autoimmune encephalomyelitis (EAE) (Rajda et al, 2015;Vogt et al, 2009). Currently, besides inhibition of inflammation, the promotion of nerve regeneration is a principle strategy for the treatment of MS (Cristofanilli et al, 2013).…”

mentioning

confidence: 96%

You-Gui pills promote nerve regeneration by regulating netrin1, DCC and Rho family GTPases RhoA, Racl, Cdc42 in C57BL/6 mice with experimental autoimmune encephalomyelitis

Liu

Chen

et al. 2016

Journal of Ethnopharmacology

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Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neuronal and oligodendroglial differentiation of human neural precursor cells in vitro

Cited by 21 publications

References 39 publications

Mechanisms of cell–cell interaction in oligodendrogenesis and remyelination after stroke

Mechanisms of cell–cell interaction in oligodendrogenesis and remyelination after stroke

Human Cerebrospinal Fluid Regulates Proliferation and Migration of Stem Cells Through Insulin-Like Growth Factor-1

You-Gui pills promote nerve regeneration by regulating netrin1, DCC and Rho family GTPases RhoA, Racl, Cdc42 in C57BL/6 mice with experimental autoimmune encephalomyelitis

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