Cerebrospinal Fluid Cytology After Stroke

Abstract

Cerebrospinal fluid (CSF) samples obtained by consecutive lumbar puncture of 26 patients with presumed pale cerebral infarction, 66 with presumed hemorrhagic infarction, 16 with lobar hematoma, and 18 with cerebral infarction verified at autopsy, were examined with a cytological method permitting a total and differential cell count. A transitory outflow of polymorphonuclear neutrophilic leukocytes (PNL) was found in 70% of the patients with hemorrhagic infarction and lobar hematoma, with a peak three to four days after onset. The strongest PNL reaction was recorded in CSF from patients with lobar hematoma. In 75% of patients with pale infarction, no PNL or only a few PNL were found. In the autopsy group the PNL reaction in the brain as well as in the CSF was stronger in patients with hemorrhagic infarcts than in those with pale infarcts. (26:489-501, 1972) Key Words.\p=m-\Cerebrospinalfluid cytology; differential diagnosis of stroke; brain infarction; lobar hematoma; cerebrospinal fluid in cerebro-$ vascular disease.

Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke.

“…Since macrophages and lymphocytes both express LFA-1, which mediates an adhesive interaction with endothelial cell ICAM-1 (51), it is possible that ICAM-1-deficient mice have diminished recruitment of these mononuclear cells, a possibility which is currently the subject of further investigation in our laboratory. This hypothesis is supported by multiple pathologic observations demonstrating macrophage and lymphocyte accumulation by 1-3 d after cerebral infarction (12,17,19,34,59).…”

Cerebrospinal Fluid in Cerebral Hemorrhage and Infarction

“…5 PNLs in the CSF may be increased sufficiently to simulate infection. 35 In our study, patients with clear CSF had minimal PNL responses in their CSF; PNL counts were never greater than 20 per cubic millimeter.…”

Human cellular inflammation in the pathology of acute cerebral ischaemia

“…An early neutrophil reaction in the CSF has been documented in clinical ischaemic stroke (less than that seen in primary cerebral haemorrhage), while monocytes appear in the CSF between three and seven days after onset 27 (table 3). There are few published reports of necropsy studies in ischaemic stroke.…”