Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type

Popp, Julius; Wolfsgruber, Steffen; Heuser, Isabella; Peters, Oliver; Hüll, Michael; Schröder, Johannes; Möller, Hans‐Jürgen; Lewczuk, Piotr; Schneider, Anja; Jahn, Holger; Luckhaus, Christian; Perneczky, Robert; Frölich, Lutz; Wagner, Michael; Maier, Wolfgang; Wiltfang, Jens; Kornhuber, Johannes; Jessen, Frank

doi:10.1016/j.neurobiolaging.2014.10.031

Cited by 133 publications

(130 citation statements)

References 41 publications

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“…The physiological stress response is modulated through the hypothalamic-pituitary-adrenal (HPA) axis [9] that stimulates the hypothalamus, which initiates the production of corticotrophin-releasing hormone (CRH). This activates the pituitary gland, which secretes adrenocorticotropic hormone (ACTH).…”

Section: Stress and Admentioning

confidence: 99%

Role of Stress, Immune System and Well-being in Patients with Alzheimer's Disease

Mp¹,

M²,

Je³

2017

J Neurol Neurosci

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Alzheimer's disease (AD) is a progressive and neurodegenerative disorder that induces neuropsychiatric symptoms, disability, caregiver burden, and premature death in patients who suffer from it. It represents the most prevalent cause of dementia in our society and its incidence rates exponentially increase with age. Currently, this disorder does not have any cure and it is essential to know all the variables and factors involved in the development of this disorder. Among these factors, there are different categories such as biological and environmental aspects. It seems that the immune system (IS) and the stress system are some of them and the knowledge about their role in this disorder is an important question in this area. Moreover, it has been demonstrated that both systems are related and this relationship can also be influenced by the emotional system. In fact, the levels of the IS biomarker (immunoglobulin A) and the stress system (cortisol) are different in people with and without AD and IgA is higher in patients with high wellbeing. Therefore, the new therapies in AD should be focused on the influence of these systems and on postulating new alternative perspectives like non-pharmacological therapies.All this is essential for the study of AD in order to improve the quality of life in these patients, as well as knowing all the variables involved, so as to generate new therapeutic targets in AD.

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Section: Stress and Admentioning

confidence: 99%

Role of Stress, Immune System and Well-being in Patients with Alzheimer's Disease

Mp¹,

M²,

Je³

2017

J Neurol Neurosci

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“…The availability of neuroimaging and biomolecular biomarkers to monitor and control brain changes structures, inflammatory processes and other biochemical pathways enable investigation of pathways that may be related to neurodegenerative disease [5,19,20].…”

Section: California Longitudinalmentioning

confidence: 99%

“…Other studies about cortisol, indicate that it might independently cause brain atrophy and the increase (peripheral and central) of the nervous system cortisol levels have been reported in neurodegenerative diseases (Alzheimer's disease) and may reflect dysfunction of cerebral components of the hypothalamic-pituitary-adrenal (HPA) axis [5,15,20]. Most studies focusing on HPA axis and cortisol in patients with AD have measured plasma, CSF or salivary cortisol levels, but, in humans, only a few observational studies have investigated whether increased salivary or plasma cortisol levels predict a more rapid disease progression in AD, reporting inconclusive results [5,14,21,22].…”

Section: California Longitudinalmentioning

confidence: 99%

“…Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic Lateral Sclerosis (ALS); Multiple Sclerosis (MS); Huntington's disease (HD); MachadoJoseph disease; Amyloid Polyneuropathy Family are characterized by a progressive loss of anatomically or physiologically related neuronal systems (cognitive function, dementia, and problems with movements) [1][2][3][4][5]. With extended life expectancy worldwide, patients suffering from these pathologies will increase in the coming years.…”

Section: Introductionmentioning

confidence: 99%

“…Cortisol levels are known to increase within minutes of a stressful event, and high cortisol levels increase activity of the hypothalamus-pituitary-adrenal (HPA) axis [4,5,17,18].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biomarkers in Neurodegenerative Diseases: Cortisol

Batista¹,

Pereira²

2016

J Mol Biomark Diagn

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Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment

2022

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Disruptions in circadian rhythms can occur in healthy aging; however, these changes are more severe and pervasive in individuals with age‐related and neurodegenerative diseases, such as dementia. Circadian rhythm alterations are also present in preclinical stages of dementia, for example, in patients with mild cognitive impairments (MCI); thus, providing a unique window of opportunity for early intervention in neurodegenerative disorders. Nonetheless, there is a lack of studies examining the association between relevant changes in circadian rhythms and their relationship with cognitive dysfunctions in MCI individuals. In this review, circadian system alterations occurring in MCI patients are examined compared to healthy aging individuals while also considering their association with MCI neurocognitive alterations. The main findings are that abnormal circadian changes in rest‐activity, core body temperature, melatonin, and cortisol rhythms appear in the MCI stage and that these circadian rhythm disruptions are associated with some of the neurocognitive deficits observed in MCI patients. In addition, preliminary evidence indicates that interventions aimed at restoring regular circadian rhythms may prevent or halt the progress of neurodegenerative diseases and mitigate their related cognitive impairments. Future longitudinal studies with repeated follow‐up assessments are needed to establish the translational potential of these findings in clinical practice.

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Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type

Cited by 133 publications

References 41 publications

Role of Stress, Immune System and Well-being in Patients with Alzheimer's Disease

Role of Stress, Immune System and Well-being in Patients with Alzheimer's Disease

Biomarkers in Neurodegenerative Diseases: Cortisol

Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment

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