Cerebrospinal Fluid as a Reflector of Central Cholinergic and Amino Acid Neurotransmitter Activity in Cerebellar Ataxia

Manyam, Bala V.; Giacobini, Ezio; Ferraro, Thomas N.; Hare, Theodore A.

doi:10.1001/archneur.1990.00530110048016

Cited by 13 publications

(3 citation statements)

References 49 publications

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“…Cholinergic therapy has previously been tried as a therapeutic option for spinocerebellar degeneration with only mild or no improvement on motor coordination 30, 31. Nevertheless, the dysfunction of brain cholinergic system observed in our study suggests that cholinergic modulating drugs may have a role in the treatment of MSA and/or SCA patients.…”

Section: Discussionmentioning

confidence: 54%

PET study of brain acetylcholinesterase in cerebellar degenerative disorders

et al. 2008

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To elucidate characteristic changes of brain acetylcholinesterase (AChE) in cerebellar degenerative disorders. Eight patients with the cerebellar variant of multiple system atrophy (MSA-C), 7 patients with spinocerebellar ataxia type-3 (SCA-3), 3 patients with SCA-6, and 13 healthy age-matched volunteers participated in this study. Brain AChE activity was measured by [(11)C] N-methylpiperidin-4-yl propionate PET in all subjects. Brain AChE activities were significantly decreased in the thalamus (-27%) and the posterior lobe of cerebellar cortex (-36%) in patients with MSA-C and in the thalamus (-23%) in patients with SCA-3 compared with healthy controls (P < 0.01). Thalamic AChE activities of SCA-3 patients were negatively correlated with the unified Parkinson's disease rating scale motor subscore (P < 0.001). AChE activities were not significantly altered in the cerebral cortex in any disease group. Reduction of AChE activities in the thalamus and cerebellum in MSA and in the thalamus in SCA-3 suggest that cholinergic modulating drugs may have a role in the treatment of ataxia and other symptoms in these disorders.

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Section: Discussionmentioning

confidence: 54%

PET study of brain acetylcholinesterase in cerebellar degenerative disorders

et al. 2008

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“…The cortical cerebellar atrophy (CCA) of idiopathic etiology constitutes a relatively straightforward neurochemical model: the loss of Purkinje cells in the cerebellar vermis (8) causes a selective decrease of the concentration of GABA in the dentate nuclei (9) and cerebrospinal fluid (CSF) (10)(11)(12)(13), with no reduction in that of glutamate (9), homovanillic acid (HVA), 5-hydroxiindolacetic acid (5-HIAA), or the noradrenergic metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) (14). Reduced consumption of glucose in the cerebellum has been determined by positron emission tomography (PET) (15).…”

Section: Cortical Cerebellar Atrophiesmentioning

confidence: 99%

“…The authors of both articles concluded that physostigmine was not effective in the treatment of this disease (13,53).…”

Section: Cortical Cerebellar Atrophiesmentioning

confidence: 99%