Cerebrospinal fluid and blood levels of neurofilament light chain in Parkinson's disease: a protocol for systematic review and meta-analysis

The 2022 Lady Estelle Wolfson lectureship on neurofilaments

“…There have been 33 meta‐analyses on the wealth of data on Nf as a biomarker for neurodegeneration over the past 15 years (Agah et al, 2018; Alagaratnam, Widekind, et al, 2021; Angelopoulou et al, 2021; Arneth & Kraus, 2022; Cai & Huang, 2018; Choong et al, 2019; Cong et al, 2021; Forgrave et al, 2019; Gao et al, 2020b; Ge et al, 2018; Hoiland et al, 2022; Hu et al, 2017; Jin et al, 2019; Karantali, Kazis, Chatzikonstantinou, et al, 2021; Karantali, Kazis, McKenna, et al, 2021; Katayama et al, 2020; Koychev et al, 2021; Li et al, 2016; Liu et al, 2022; Liu, Chen, et al, 2020; Martin et al, 2019; Mondello et al, 2021; Peng et al, 2022; Petzold et al, 2007; Rübsamen et al, 2022; Sako et al, 2015; Sferruzza et al, 2021; Wang et al, 2019; Wang et al, 2020a; Wang et al, 2020b; Xu et al, 2016; Zhang et al, 2022; Zhao et al, 2019; Zhou et al, 2021).…”

“…Four meta‐analyses included data on PD (Angelopoulou et al, 2021; Ge et al, 2018; Hu et al, 2017; Sako et al, 2015). Another two meta‐analyses are planned (Wang et al, 2020a; Wang et al, 2020b). A potentially diagnostically interesting increase of CSF NfL in individuals with PD ( n = 1035) from those with atypical parkinsonian syndromes ( n = 930) was found (Angelopoulou et al, 2021).…”

“…The difference of 1.26 standard deviations is of interest for studies operating on a group level and expands on an earlier meta‐analysis on four studies (1.60; 95% CI 1.22–1.98) (Sako et al, 2015). The differential use of a fixed‐effect model ( 50%) versus random‐effect model ( 50%) was announced as depending on the degree of statistical heterogeneity in one protocol for blood NfL (Wang et al, 2020b) which reads similar to the protocol published for CSF NfL (Wang et al, 2020a). 2…”

“…Five meta-analyses included data on ALS (Forgrave et al, 2019;Li et al, 2016;Sferruzza et al, 2021;Xu et al, 2016;Zhou et al, 2021). Similar to PD (Wang et al, 2020a(Wang et al, , 2020b there is an ongoing, protocolised meta-analysis (Agah et al, 2018). The most complete meta-analysis on disease (n = 16 studies) comparison demonstrated higher blood NfL levels in individuals with ALS (n = 930) if compared to cognitively unimpaired controls (n = 593) with an effect size of 9.64 (95% CI 6.65-13.99) (Forgrave et al, 2019).…”