Cerebrospinal fluid acid-base balance during respiratory alkalosis in the panting animal

Hales,; Bligh, John; Maskrey, M.

doi:10.1152/ajplegacy.1970.219.2.469

Cited by 20 publications

(7 citation statements)

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“…Evidently, alveolar ventilation increased by more than that due to the increase in COµ production. This fall is smaller than the >20 mmHg fall seen in animals that pant (Hales & Webster, 1967;Hales & Bligh, 1969;Hales et al 1970) and is smaller Additional respiratory drive in hyperthermia Exp. Physiol.…”

Section: Resultsmentioning

confidence: 69%

“…Despite the increased ventilation of dead space in these species, however, the additional respiratory drive also causes alveolar ventilation to increase by more than, rather than in proportion to, the increase in COµ production at raised temperatures. This increase in alveolar ventilation drives the mean Pa,COµ level below 40 mmHg, falling to 20 mmHg or below (Hales & Bligh, 1969;Hales et al 1970;Monteau et al 1974). The presence of the additional respiratory drive, however, ensures that such hypocapnia does not cause apnoea.…”

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confidence: 97%

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A respiratory drive in addition to the increase in CO2 production at raised body temperature in rats

2000

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Section: Resultsmentioning

confidence: 69%

mentioning

confidence: 97%

A respiratory drive in addition to the increase in CO2 production at raised body temperature in rats

2000

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“…That is at some level, a thermoregulation-induced hyperventilation must compete against a chemoregulatory-induced hypoventilatory drive caused by the hypocapnia and alkalosis that was witnessed in our subjects (Hales et al 1970). This could suggest even that a hierarchical importance is placed on varying linear exercise-induced fatigue constructs (Abbiss and Laursen 2005).…”

Section: Discussionmentioning

confidence: 77%

Hyperthermic-induced hyperventilation and associated respiratory alkalosis in humans

2007

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The purpose of this study was to determine if increased environmental heat leads to hyperthermic-induced hypocapnia and associated alkalosis during prolonged self-paced cycling. Nine male cyclists completed three 100 km stochastic time trials in hot (34 degrees C), neutral (22 degrees C) and cold (10 degrees C) environments. Intermittent measurements of rectal and skin temperature, expired gases, blood pH, PaCO(2), PaO(2), and bicarbonate were made throughout. Rectal temperature increased significantly throughout all trials (P < 0.001) and was significantly correlated with increases in the ventilatory equivalent for carbon dioxide (Ve/ VCo2; r = 0.77; P < 0.001) and blood pH (r = 0.69; P < 0.05). Rectal temperature was also negatively correlated with a reduction in PaCO(2) (r = -0.80; P < 0.001). PaO(2) and bicarbonate concentration remained constant throughout all trials. This study has shown that prolonged self-paced cycling is associated with a hyperthermic-induced hyperventilation, causing a decrease in arterialized carbon dioxide tension and consequential respiratory alkalosis.

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“…Rapid external or internal cooling was achieved by passing cold tap water (14-18 'C) through either the external or internal coil at a rate of 300-780 ml./min for 60 min. Experiments also were carried out in which water was passed for 60 min through either coil at a slower rate (6-38 ml./min) adjusted to cause a fall in fetal temperature of 06-1-0 C in 20 min ('summit metabolism, Alexander & Williams, 1968 (Hales, Bligh & Maskrey, 1970 The effect of cooling on fetal blood gases is shown in Table 2. As previously described and discussed, (Gunn & Gluckman, 1983) fetal Po2 fell during fast external cooling and there was also a small but significant fall in CoC2 after 60 min.…”

Section: Methodsmentioning

confidence: 99%

The effect of cooling on breathing and shivering in unanaesthetized fetal lambs in utero.

Gluckman¹,

Gunn²,

Johnston³

1983

The Journal of Physiology

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SUMMARY1. The effects of cooling have been studied in chronically instrumented unanaesthetized fetal lambs of 106-132 days gestation.2. Cold stimulation of cutaneous thermoreceptors by means of a coil placed around the fetus in the amniotic cavity induced continuous breathing which was associated with high-voltage electrocortical activity throughout the cooling period.3. Direct internal cooling by means of an intragastric cooling coil did not alter fetal breathing or sleep-state patterns.4. Shivering occurred in response to both external and internal cooling, and this response was present as early as 106 days gestation, well before the appearance of high-voltage sleep.5. In older fetuses there was evidence of a reduction in thermoregulatory responses during low-voltage electrocortical activity, but not of the complete suspension of thermoregulation characteristic of low-voltage (r.e.m.) sleep seen in mature animals.6. It is concluded that deep regular breathing associated with high-voltage electrocortical activity can be induced by cold stimulation of cutaneous thermoreceptors, but not by a reduction in core temperature alone. Furthermore, fetal responses to cooling are present as early as 106 days gestation.

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Cerebrospinal fluid acid-base balance during respiratory alkalosis in the panting animal

Cited by 20 publications

References 0 publications

A respiratory drive in addition to the increase in CO2 production at raised body temperature in rats

A respiratory drive in addition to the increase in CO2 production at raised body temperature in rats

Hyperthermic-induced hyperventilation and associated respiratory alkalosis in humans

The effect of cooling on breathing and shivering in unanaesthetized fetal lambs in utero.

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