Cerebroprotective effect of pterostilbene against global cerebral ischemia in rats

Abstract

The role of pterostilbene against induced neurobehavioral alterations in global cerebral ischemiareperfusion and oxidative damage was studied. Materials and methods: Male SD rats (180-200 g) were exposed for 30 min to bilateral carotid artery occlusion accompanied by 60 min reperfusion to cause cerebral injury. Pretreatment with pterostilbene (200 and 400 mg/ kg, orally) was given to the animals for ten days followed by ischemia-reperfusion injury. Various behavioral tests (locomotor activity, neurological score, transfer latency, hanging wire test) were studied. The brain tissues of animals were used for both the biochemical parameters (lipid peroxidation, reduced glutathione, superoxide dismutase, catalase activity) and histopathological study. Result: The pterostilbene as given orally significantly improved neurobehavioral alterations compared to control ischemia-reperfusion. Treatment with pterostilbene (200, and 400 mg/kg, orally) also significantly attenuated oxidative damage as indicated by reduced lipid peroxidation, nitrite concentration, restored reduced glutathione, and catalase activity as compared to control (ischemia-reperfusion) animals. Overall, pterostilbene treated animals showed non significant histological alteration as compared to ischemia-reperfusion control. Conclusion: This work suggests the beneficial effect of pterostilbene and its therapeutic potential against reperfusion-induced ischemia and associated behavioral changes in rats due to the stabilization of DNA damage with significant free radical scavenging properties.

Pterostilbene as a Therapeutic Alternative for Central Nervous System Disorders: A Review of the Current Status and Perspectives

“…It was found that after ischemic stroke, intracranial perfusion was reduced, SOD, GSH, and CAT levels decreased, and lipid peroxidation (LPO) levels, a measure of the severity of oxidative damage to brain tissue, increased, all of which were significantly reversed and returned to near-healthy levels in a group pretreated with pterostilbene. Pterostilbene treatment also inhibited the production of ROS, acting as a free radical scavenger and protecting neurons, demonstrating the therapeutic potential of pterostilbene for cerebral ischemia–reperfusion injury . In addition, pterostilbene can also inhibit oxidative stress by regulating a number of pathways.…”

“…Pterostilbene treatment also inhibited the production of ROS, acting as a free radical scavenger and protecting neurons, demonstrating the therapeutic potential of pterostilbene for cerebral ischemia− reperfusion injury. 107 In addition, pterostilbene can also inhibit oxidative stress by regulating a number of pathways. The Nrf2/ HO-1 pathway is a major regulatory pathway for intracellular antioxidant defense.…”

Dietary pterostilbene exerts potential protective effects by regulating lipid metabolism and enhancing antioxidant capacity on liver in broilers

“…Our previous study found that PT improved the quality of chicken breast meat through enhancing the antioxidant enzymes expression related to Nrf2 pathway and reducing lipid and protein oxidation. In the therapy of reperfusion‐induced ischaemia rats, PT showed the free radical scavenging property by increasing the activities of CAT and GSH (Khan et al, 2021). PT was reported to alleviate diquat‐induced jejunum damage of chicken via regulating redox status mediated by Nrf2 and ferroptosis (Chen et al, 2023).…”

Polydopamine-modified black phosphorus nanosheet drug delivery system for the treatment of ischemic stroke

“…In vivo studies have revealed Pte’s antioxidant, anti-apoptotic, anticancer, and anti-inflammatory properties [ 27 ], making Pte a potential therapeutic agent for treating various diseases, including IS. Badruddeen et al [ 28 ] found that Pte affected reperfuse-induced ischemia and related behavioral changes in rats. Owing to its antioxidant and free radical scavenging properties, and its ability to regulate neurodegenerative brain oxidative damage, Pte can be used as a neuroprotective adjuvant to effectively eradicate oxidative stress during in vivo ischemic injury [ 29 , 30 ].…”