Cerebrolysin Alleviating Effect on Glutamate-Mediated Neuroinflammation Via Glutamate Transporters and Oxidative Stress

Avci, Seydanur; Günaydın, Şükran; Ari, Neziha Senem; Sulukoğlu, Emine Karaca; POLAT, Özlem EROL; Gecili, Ibrahim; Yeni, Yeşim; Yilmaz, Aysegul; Genç, Sıdıka; Hacımüftüoğlu, Ahmet; Yıldırım, Serkan; Mokresh, Muhammed Yasser; Fındık, Damla Gül; Tsatsakis, Aristidis; Margină, Denisa; Tsarouhas, Konstantinos; Wallace, David R.; Taghizadehghalehjoughi, Ali̇

doi:10.1007/s12031-022-02078-8

Cited by 11 publications

(7 citation statements)

References 29 publications

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“…Cerebrolysin also shows its protective properties in reducing oxidative stress and lipid peroxidation. Avci et al, their 2022 study on primary cortex neurons, also showed the antioxidant and also abilities of lowering the inflammatory cytokine level of Cerebrolysin [46]. They also indicated a positive effect on glutamate transporters, which also plays a role in neurotoxicity leading to cell death [46].…”

Section: Discussionmentioning

confidence: 97%

Cerebrolysin in Patients with Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis

Kojder,

Jarosz,

Bosiacki

et al. 2023

JCM

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Subarachnoid Hemorrhage (SAH) is one of the acute neurological conditions that is associated with high mortality and recovery failure rates. In recent years, due to the development of endovascular and classical techniques, the mortality rate after SAH has decreased. Currently, more research is focused on understanding the molecular mechanisms underlying SAH. Methods of treatment are investigated in order to obtain the best treatment result, not only survival. One of the drugs used in stroke, including SAH, is Cerebrolysin. It is a mixture of neuropeptides that has similar properties to neurotrophic factors. Its positive impact on strokes has been analyzed; however, there are no meta-analyses concerning only the subpopulation of patients diagnosed with SAH in the current literature. Therefore, we conducted a meta-analysis of available clinical trials to evaluate the effect of Cerebrolysin on the treatment outcome. The data suggest a positive effect of Cerebrolysin on the mortality of SAH patients. However, further randomized clinical trials with larger groups of patients are needed to draw final conclusions.

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Section: Discussionmentioning

confidence: 97%

Cerebrolysin in Patients with Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis

Kojder,

Jarosz,

Bosiacki

et al. 2023

JCM

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“…Cerebrolysin, a mixture of enzymatic processing peptides from pig brains, protects neurons, primarily by reducing glutamate concentration in the synaptic clefts. In addition, it may reduce oxidative stress and harm to neuronal cells by boosting antioxidant activity and lowering levels of inflammatory cytokines according to the data from Avci et al ( 53 ). In another study, a bioactive natural product called crocin was able to not only inhibit the production of reactive oxygen species and the secretion of pro-inflammatory cytokines but also reduce the inflammation of various organs/systems ( 54 ).…”

Section: Discussionmentioning

confidence: 99%

Altered brain network centrality in patients with orbital fracture: A resting‑state functional MRI study

Liu,

Gao,

Shu

et al. 2023

Exp Ther Med

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The present study aimed to investigate potential functional network brain-activity abnormalities in individuals with orbital fracture (OF) using the voxel-wise degree centrality (DC) technique. The present study included 20 patients with OF (12 males and 8 females) and 20 healthy controls (HC; 12 males and 8 females), who were matched for gender, age and educational attainment. Functional magnetic resonance imaging (fMRI) in the resting state has been widely applied in several fields. Receiver operating characteristic (ROC) curves were calculated to distinguish between patients with OF and HCs. In addition, correlation analyses were performed between behavioral performance and average DC values in various locations. The DC technique was used to assess unprompted brain activity. Right cerebellum 9 region (Cerebelum_9_R) and left cerebellar peduncle 2 area (Cerebelum_Crus2_L) DC values of patients with OF were increased compared with those in HCs. Cerebelum_9_R and Cerebelum_Crus2_L had area under the ROC curve values of 0.983 and 1.000, respectively. Patients with OF appear to have several brain regions that exhibited aberrant brain network characteristics, which raises the possibility of neuropathic causes and offers novel therapeutic options.

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“…Mitochondrial damage is a key marker of aging, and damaged mitochondria can regulate innate immunity through REDOX signaling or direct inflammasome activation [ 13 ]. Oxidative stress is believed to be a primary factor in neurodegenerative diseases, as well as in the normal aging process [ 14 ]. Mice injected with d -galactose have been used as an animal model of oxidative stress [ 15 ], and d -galactose-induced rat models have been widely used in aging and other research areas.…”

Section: Introductionmentioning

confidence: 99%

Effect of acupuncture therapy on vaccine-induced immune response in d-galactose-induced aging rats

Li,

Liang,

Xiao

et al. 2023

Heliyon

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Cerebrolysin Alleviating Effect on Glutamate-Mediated Neuroinflammation Via Glutamate Transporters and Oxidative Stress

Cited by 11 publications

References 29 publications

Cerebrolysin in Patients with Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis

Cerebrolysin in Patients with Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis

Altered brain network centrality in patients with orbital fracture: A resting‑state functional MRI study

Effect of acupuncture therapy on vaccine-induced immune response in d-galactose-induced aging rats

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