CerebralDermabacter hominis abscess

Bavbek, Murad; Caner, Hakan; Arslan, Hande; Demirhan, Beyhan; Tunçbilek, Semra; Altınörs, Nur

doi:10.1007/bf02771848

Cited by 19 publications

(11 citation statements)

References 20 publications

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“…D. hominis is a recently established species, and its recognition as an opportunistic human pathogen is even newer. Very few case reports of documented infections caused by D. hominis have been published (2,7). A search in the database of 16S rRNA gene sequences of the National Center for Biotechnology Information for Dermabacter sp.…”

Section: Case Reportmentioning

confidence: 99%

“…The MICs of ␤-lactam antibiotics tested are higher for this isolate than has been reported previously by others (5). Chloramphenicol, ciprofloxacin, clindamycin, erythromycin, and aminoglycosides other than amikacin have shown reduced activity against most D. hominis isolates (2,5,6). Susceptibility testing of clinically important D. hominis isolates is therefore highly warranted.…”

Section: Case Reportmentioning

confidence: 99%

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Peritoneal Dialysis-Associated Peritonitis Caused by Dermabacter hominis

Radtke¹,

Bergh

Øien

et al. 2001

J Clin Microbiol

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Dermabacter hominis was the cause of a peritoneal dialysis-associated peritonitis. D. hominis was identified by phenotypic criteria and by sequencing the 16S rRNA gene. Clinical cure was achieved with cefuroxime treatment despite the isolate's reduced susceptibility to this drug (MIC, 12 mg/liter) on in vitro testing. The successful treatment was probably due to the high concentrations attained by intraperitoneal administration of the drug. CASE REPORTOur patient was a 67-year-old woman with end-stage renal disease due to hypertensive kidney disease. Since 1994 she had been receiving renal replacement therapy with peritoneal dialysis (PD), which was exclusively performed as continuous ambulatory peritoneal dialysis (CAPD). She was admitted to the hospital at the end of March 2000 with symptoms of peritonitis. Cultures of the dialysate yielded coagulase-negative staphylococci. The infection was successfully treated with cloxacillin given intraperitoneally. In the middle of April, the cuff of the dialysis catheter (singlecuff Quinton-Tenckhoff catheter, 41 cm long) slid out. The catheter was therefore exchanged. Resumption of dialysis after this was uncomplicated. Almost 3 weeks later, while still in the hospital awaiting transfer to a nursing home, she again became ill with abdominal pain and a hazy dialysate. The PD effluent contained 0.54 ϫ 10 9 leukocytes per liter. We routinely culture peritoneal fluid from PD patients with signs of peritonitis in Vital aerobic and anaerobic blood culture bottles (bioMerieux SA, La Balmes-des-Grottes, France). Two sets of samples were obtained on day 1, and one set of samples was obtained on each of the following 2 days. A gram-positive coryneform bacterium grew in all bottles from days 1 and 2 and in the aerobic bottle from day 3. Growth occurred after 18 to 24 h in the aerobic bottles and after approximately 4 days in the anaerobic bottles. A swab from the catheter exit site yielded no growth.From day 1 the patient was empirically treated with a combination of intraperitoneal cloxacillin (125 mg/liter of dialysis fluid) and netilmicin (6.25 mg/liter) in 2-liter bags in each of the four daily instillations. New samples taken on day 6 yielded growth of the same coryneform bacterium, although the dialysate had cleared and the patient was improving. Because of the results of disk diffusion susceptibility testing, treatment was changed to cefuroxime (125 mg/liter of dialysis fluid) and continued for a further 14 days, achieving clinical cure. Cultures from days 8 and 13 were sterile.Microbiology. The peritoneal fluid inoculated into blood culture bottles yielded bacteria that grew on blood agar and chocolate agar (but best on blood agar) as 0.5-to 1-mmdiameter white colonies after 18 h. The colonies were white, convex, slightly viscid, and catalase positive and had a sweet, pungent odor. As judged from the blood culture bottles, the organism was nonmotile and gram positive and had coryneform morphology without branching. The isolate hydrolyzed esculin and was nitrate and xylose ...

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Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Peritoneal Dialysis-Associated Peritonitis Caused by Dermabacter hominis

Radtke¹,

Bergh

Øien

et al. 2001

J Clin Microbiol

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“…Among them, strains of the genus Dermabacter were first isolated from human skin and assigned to a novel species of this new genus, Dermabacter hominis . Members of the genus Dermabacter have been recognized as CDC group 3 and group 5 coryneform bacteria based on 16S rRNA gene sequence analysis (Funke et al, 1994), and have subsequently been isolated from a variety of clinical specimens, such as blood cultures (Gó mez-Garcés et al, 2001), fatal septicaemia (Lee et al, 2011), cutaneous abscesses (Martin et al, 2009), peritoneal fluid (Radtke et al, 2001), a brain biopsy specimen (Bavbek et al, 1998) and chronic osteomyelitis (Van Bosterhaut et al, 2002), suggesting this micro-organism to be an opportunistic pathogen. It has been more than 25 years since Dermabacter hominis was first described.…”

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confidence: 99%

Dermabacter vaginalis sp. nov., isolated from human vaginal fluid

Chang

Rhee

Kim

2016

International Journal of Systematic and Evolutionary Microbiology

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A novel actinobacterial strain, T , was isolated from the vaginal fluid of a Korean female and was characterized by a polyphasic approach. The strain was a facultatively anaerobic, Gram-stain-positive, non-spore-forming, non-motile, catalase-positive and oxidase-negative short rod. Colonies were creamy white, of low convexity and 1-2 mm in diameter after growth on DSM 92 agar plates at 37 8C for 2 days. The most closely related strains were Dermabacter hominis DSM 7083 T and Helcobacillus massiliensis 6401990 T (98.3 and 96.3 % 16S rRNA gene sequence similarity, respectively). The isolate grew optimally at 37 8C and pH 7 in the presence of 0.5 % (w/v) NaCl. The cell-wall peptidoglycan contained meso-diaminopimelic acid and the cell-wall hydrolysates contained ribose, galactose and glucose. The DNA G+C content was 62.6 mol% and the mean DNA-DNA relatedness value of the isolate to D. hominis DSM 7083 T was 31.1¡3.0 % (reciprocal: 48.2¡5.3 %). The major cellular fatty acids (.10 %)were anteiso-C 17 : 0 , anteiso-C 15 : 0 and iso-C 16 : 0 , and the menaquinones were MK-9, MK-8 and MK-7. The polar lipid profile of strain AD1-86 T consisted of diphosphatidylglycerol, phosphatidylglycerol, two aminolipids and a glycolipid. Data from this polyphasic study indicate that strain AD1-86 T represents a novel species of the genus Dermabacter, for which the name Dermabacter vaginalis sp. nov. is proposed; the type strain is AD1-86 T (5KCTC 39585 T 5DSM 100050 T ).

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“…Although the Special Bacteriology Reference Laboratory at the Centers for Disease Control and Prevention (CDC) also proposed new coryneform bacteria as CDC groups 3 and 5 (Hollis, 1992), they were assigned to the genus Dermabacter based on 16S rRNA gene sequencing (Funke et al, 1994) and recognized to represent D. hominis by DNA-DNA hybridization (Gruner et al, 1994). D. hominis is a relatively rare pathogen and is infrequently isolated from clinical specimens, including blood cultures, abscesses, wounds, bone, eye and joint fluid (Bavbek et al, 1998;Gómez-Garc es et al, 2001;Radtke et al, 2001). Recently, infection caused by this pathogen has also been reported in Korea (Lee et al, 2011).…”

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confidence: 99%

Dermabacter jinjuensis sp. nov., a novel species of the genus Dermabacter isolated from a clinical specimen

Park

Lee

Cho

et al. 2016

International Journal of Systematic and Evolutionary Microbiology

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A Gram-stain-positive, catalase-positive, facultatively anaerobic, non-motile, coryneform bacterium, designated strain 32 T , was isolated from a closed pus sample from a patient having finger necrosis in Korea. Strain 32 T was considered as representing a novel species according to its initial identification by matrix-assisted laser desorption/ionization-time-of-flight MS. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain 32 T belonged to the genus Dermabacter and was closely related to Dermabacter hominis DSM 7083 T (=ATCC 49369 T ) (98.34 % similarity). Optimal growth was observed at 30-40 C and pH 7. Growth occurred in the presence of 0-6 % (w/v) NaCl. Menaquinones MK-8, MK-7 and MK-9 were the major respiratory quinones. The major polar lipids were phosphatidylethanolamine, phosphatidylcholine, glycolipid and two unknown lipids. The major cellular fatty acids were anteiso-C 17 : 0 , anteiso-C 15 : 0 , iso-C 16 : 0 and iso-C 15 : 0 . The DNA G+C content of strain 32 T was 62.58 mol%, and the mean level of DNA-DNA relatedness between strain 32 T and D. hominis ATCC 49369 T was 49±1.6 %. Based on the phenotypic and genotypic characteristics, strain 32 T is confirmed to represent a novel species of the genus Dermabacter, for which the name Dermabacter jinjuensis sp. nov. is proposed. The type strain is 32 T (=NCCP 16133 T =DSM 101003 T ).

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CerebralDermabacter hominis abscess

Abstract: Dermabacter species are commonly isolated from the skin and other body sites but rarely show pathogenicity in humans. A case of Dermabacter hominis cerebral abscess is reported which presented as a contrast-enhancing intracranial mass in a renal transplant patient.

Cited by 19 publications

References 20 publications

Peritoneal Dialysis-Associated Peritonitis Caused by Dermabacter hominis

Peritoneal Dialysis-Associated Peritonitis Caused by Dermabacter hominis

Dermabacter vaginalis sp. nov., isolated from human vaginal fluid

Dermabacter jinjuensis sp. nov., a novel species of the genus Dermabacter isolated from a clinical specimen

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