Cerebral White Matter Lesions and Affective Episodes Correlate in Male Individuals with Bipolar Disorder

Birner, Armin; Seiler, Stephan; Lackner, Nina; Bengesser, Susanne; Queissner, Robert; Fellendorf, Frederike T.; Platzer, Martina; Ropele, Stefan; Enzinger, Christian; Schwingenschuh, Petra; Mangge, Harald; Pirpamer, Lukas; Deutschmann, Hannes; McIntyre, Roger S.; Kapfhammer, Hans-Peter; Reininghaus, Bernd; Reininghaus, Eva

doi:10.1371/journal.pone.0135313

Cited by 19 publications

(13 citation statements)

References 77 publications

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“…It is interesting that a recent paper demonstrated that the number of depressive and manic episodes is positively correlated with WML load but the correlation seems to be stronger in the case of mania. This may support our hypothesis that mania has a more intimate relationship with cardiovascular disorders (including hypertension) than depression [ 29 - 31 ].…”

Section: Similarities and Differences Between Essential Hsupporting

confidence: 83%

Is Mania the Hypertension of the Mood? Discussion of A Hypothesis

Rihmer

Gonda²,

Döme³

2017

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Beyond both being biphasic/bidirectional disorders (hypo)mania and essential hypertension share a surprising number of similarities and an overlap between their genetics, biological background, underlying personality and temperamental factors, precipitating factors, comorbidity and response to treatment, indicating a possibly partially shared biological background. Based on theoretical knowledge, similarities related to characteristics, manifestation and course, and the results of pharmacological studies related to the effects and side effects of pharmacotherapies used in the treatment of these two distinct disorders, the authors outline a hypothesis discussing the similar origins of these two phenomena and thus mania being the hypertension of mood in memory of Athanasios Koukopoulos, one of the greatest researchers and theoreticists of mania of all time.

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Section: Similarities and Differences Between Essential Hsupporting

confidence: 83%

Is Mania the Hypertension of the Mood? Discussion of A Hypothesis

Rihmer

Gonda²,

Döme³

2017

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“…Recently, it has been demonstrated that depression is associated with deep and periventricular white matter hyperintensities on MRI (Wang et al 2014;Birner et al 2015). None of our patients had clinically significant depression or was treated by antidepressants.…”

Section: Discussionmentioning

confidence: 63%

“…2014; Birner et al. 2015). None of our patients had clinically significant depression or was treated by antidepressants.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance brain imaging in patients with visual vertigo

et al. 2015

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IntroductionPatients with visual vertigo (VV) report dizziness provoked by moving visual surroundings. It has been suggested that these subjects develop a compensation strategy for a vestibulo‐proprioceptive deficit and rely excessively on visual input. We have postulated that patients with VV might have brain abnormalities that interfere with appropriate processing of visual stimulation and performed a brain MRI study to verify this hypothesis.Materials and MethodsPatients with VV of more than 3 months duration were included. They were asked to complete the Situational Characteristic Questionnaire (SCQ) that scores for the symptoms of VV. Dizzy patients without VV served as controls. A brain MRI was performed with a Siemens 1.5 Tesla scanner in patients and controls.ResultsTwenty‐four patients with VV were included. Their mean SCQ score was 1.45 ± 0.9 (normal 0.16 ± 0.28). In 50% of patients, abnormalities in MRI imaging were found. Thirty‐three percent of 27 controls demonstrated an abnormal brain MRI. The two groups were similar in respect to the prevalence of a localized hemispheric or posterior fossa lesion (P = 0.13), but VV patients had more unspecific white matter brain changes than controls (P = 0.009). Patients and controls did not differ in age and gender distribution (P = 0.9) or the history of a neurotological event preceding their symptoms (P = 0.3).ConclusionsOur study suggests that multiple white matter lesions might contribute to occurrence of the phenomenon of VV. Future prospective large‐scale studies by specific MR techniques are indicated to validate our preliminary findings and elucidate the pathological mechanism of VV.

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“…3 Several studies have compared WMHs in adults with BD and healthy controls (HC). [4][5][6][7][8][9][10][11] While most studies on this topic have reported increased WMH prevalence in BD, [4][5][6][7][8][9] some studies have reported equivalent rates in BD and HC. [10][11][12] The reported WMH prevalence rates vary widely across studies, ranging from 18-100% in people with BD.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of white matter hyperintensities is not elevated in a large sample of adolescents and young adults with bipolar disorder

Mehrhof

Popel

Mio

et al. 2021

Braz. J. Psychiatry

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Objective: The increased prevalence rate of white matter hyperintensities is one of the most consistently reported brain abnormalities in adults with bipolar disorder. However, findings in children and adolescents with bipolar disorder are less consistent. Prior studies have been constrained by small sample sizes and/or poor age-and sex-matching of healthy controls. We examined this topic in the largest sample of adolescents with bipolar disorder to date. Methods: T 2-weighted 3-Tesla magnetic resonance imaging data were acquired for 83 adolescents with bipolar disorder diagnosed via the Kiddie Schedule for Affective Disorders and the Schizophrenia, Present and Lifetime version semi-structured interview and 64 age-and sex-matched healthy controls. All acquired scans were examined by neuroradiologists and the presence or absence of white matter hyperintensities was determined for each participant. Results: The prevalence of white matter hyperintensities did not differ between adolescents with bipolar disorder (13.3%) and controls (21.9%; w 2 = 1.90; p = 0.168). Conclusion: In contrast to the study hypothesis, the prevalence of white matter hyperintensities was not higher in adolescents with bipolar disorder than controls. The large sample size and good matching for age and sex bolster the reliability of this negative finding. Future studies are warranted to evaluate the prevalence, incidence, and predictors of white matter hyperintensities in early-onset bipolar disorder prospectively.

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Cerebral White Matter Lesions and Affective Episodes Correlate in Male Individuals with Bipolar Disorder

Cited by 19 publications

References 77 publications

Is Mania the Hypertension of the Mood? Discussion of A Hypothesis

Is Mania the Hypertension of the Mood? Discussion of A Hypothesis

Magnetic resonance brain imaging in patients with visual vertigo

Prevalence of white matter hyperintensities is not elevated in a large sample of adolescents and young adults with bipolar disorder

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