Cerebral Venous Thrombosis in Children

Carvalho, Karen S.; Connolly, Patrick J.; Garg, Bhuwan P.

doi:10.2310/7010.2001.16834

Cited by 46 publications

(82 citation statements)

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“…The latter possibly accounts for the general good outcome in this population compared to previously documented outcomes of childhood CSVT [5,11,20,45]. Death resulting from sinus venous thrombosis in a nephrotic child remains, to our knowledge, exceptional [40].…”

Section: Discussionmentioning

confidence: 91%

“…Diagnosis remains difficult due to often variable and subtle presentation, but early diagnosis is necessary to prevent serious morbidity [5,11]. The clinical presentation of CSVT in our population did not differ from previous paediatric series, was non-specific and included seizures and signs and symptoms of raised intracranial pressure such as headache, vomiting, altered level of consciousness and papilloedema [5,11,20,45]. Despite increased awareness, the diagnosis was not considered initially in three of our four patients, which delayed brain imaging studies and management.…”

Section: Discussionmentioning

confidence: 99%

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Cerebral sinovenous thrombosis and idiopathic nephrotic syndrome in childhood: report of four new cases and review of the literature

2006

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Cerebral sinovenous thrombosis and idiopathic nephrotic syndrome in childhood: report of four new cases and review of the literature

2006

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“…The median age was 14 years (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Six of the patients (54.5%) presented with the complaint of headache.…”

Section: Resultsmentioning

confidence: 99%

“…Seizure was observed in a two-year old patient who developed thrombosis following trauma. In the literature, cerebral thrombosis has been usually manifested with seizure and focal signs in infants and young children, whereas headache has been reported with a higher rate and altered consciousness and seizures have been reported more rarely in older children (15).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cases with cerebral thrombosis in children

et al. 2016

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Aim: We aimed to evaluate the patients who were followed up in our clinic with a diagnosis of cerebral sinovenous thrombosis in terms of age, sex, clinical findings, etiology, thrombophilic factors, imaging findings, treatment and prognosis. Material and Methods:The files of 11 patients who were followed up in our pediatric neurology clinic with a diagnosis of cerebral thrombosis between 1 December 2010 and 31 December 2014 were retrospectively analyzed. Results:Seven of 11 patients were male (63.6%). The median age was 14 years (2-17 years). Six (54%) of the patients presented with a complaint of headache. Other complaints at presentation included diplopia (n:3), weakness and difficulty in speaking (n:1) and seizure (n:1). A diagnosis of pseudotumor cerebri was made in eight of the patients (72.7%). In the etiology, mastoiditis was found in three patients, mastoiditis and meningitis were found in combination in one patient, Behçet's disease was found in three patients and head trauma was found in one patient. In 3 patients, only prothrombotic genetic risk factors were present; one patient had deficiency of protein C and S, one patient had deficiency of antithrombin III and one patient had hyperhomosisteinemia in association with vitamin B12 deficiency. 1A homozygous MTFHR A1298C mutation was detected in the patient who had mastoiditis and meningitis and protein S deficiency and lupus anticoagulant were found in another patient who had mastoiditis. All patients received anticoagulant treatment and all patients recovered without neurological sequelae except one.Conclusions: Cerebral sinovenous thrombosis should be considered in patients who present with headache and focal neurological deficits. Appropriate utilization of imaging studies is necessary for the diagnosis. Detailed ear, nose and throat examination should be performed to detect mastoiditis. It is recommended that genetic risk factors should be investigated, because hereditary thrombophilis factors may have a role in children. Behçet's disease which is relatively common in our country should be considered in differential diagnosis. (Turk Pediatri Ars 2016; 51: 87-93)

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“…Patients younger than 18 years of age with venous thrombosis are reported to have a greater than 50% likelihood of carrying a genetic thrombophilic defect, and two thirds of such defects will be in factor V [45]. Case series of cerebral venous thrombosis in children from various acute causes, including dehydration, indicate that thrombosis is unlikely to occur in the absence of background coagulopathy [46].…”

Section: Intracerebral Complications Other Than Idiopathic Cerebral Ementioning

confidence: 98%

Hyperglycemic Comas in Children: New Insights into Pathophysiology and Management

Rosenbloom

2005

Rev Endocr Metab Disord

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Cerebral Venous Thrombosis in Children

Cited by 46 publications

References 0 publications

Cerebral sinovenous thrombosis and idiopathic nephrotic syndrome in childhood: report of four new cases and review of the literature

Cerebral sinovenous thrombosis and idiopathic nephrotic syndrome in childhood: report of four new cases and review of the literature

Evaluation of cases with cerebral thrombosis in children

Hyperglycemic Comas in Children: New Insights into Pathophysiology and Management

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