Cerebral venous thrombosis associated with tuberculous meningitis: a rare complication of a common disease

Ramdasi, Raghvendra; Mahore, Amit; Kawale, Juhi; Thorve, Smita

doi:10.1007/s00701-015-2493-6

Cited by 11 publications

(7 citation statements)

References 3 publications

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“…12,31 Very little is known about venous involvement; a few factors such as stasis, endothelial inflammation and hypercoagulable state are considered to contribute to venous sinus thrombosis. [32][33][34] MRA abnormality presented in 43.2% of all TBM cases, which differs from prior studies, probably related to the imaging techniques used: DSA, CTA and MRA. 3,5,6,13,15 The MCA (84.4%) was the most common artery involved, followed by the ACA (42.3%) and ICA (34.6%), consistent with previous studies ( Table 6).…”

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confidence: 85%

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Cerebrovascular complications in tuberculous meningitis—A magnetic resonance imaging study in 90 patients from a tertiary care hospital

et al. 2019

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Background Cerebrovascular complications of tuberculous meningitis (TBM) are associated with increased morbidity and mortality. We retrospectively reviewed clinicoradiological findings of 90 TBM patients who presented to a tertiary care hospital, with emphasis on frequency and distribution of infarcts on diffusion imaging and pattern of vascular involvement on magnetic resonance (MR) angiography (MRA). Materials and methods MR images of 90 TBM patients at presentation (2012–2018) were coanalyzed by two radiologists for tuberculomas, leptomeningeal enhancement (LM), hydrocephalus, infarct and vascular abnormalities. Infarcts were categorized based on location (“tubercular” (TB) or “ischemic” zones) and arterial supply (perforators and cortical branches). Clinical and laboratory findings were correlated with imaging data. Results Ninety TBM patients (age 10–82 years) were enlisted after application of inclusion criteria. Tuberculomas were most common (100%) followed by LM (84.4%), cerebral infarcts (57.7%) and hydrocephalus (29%). Location-wise, 35% infarcts were in ischemic, 13% in TB and 15% in both zones. According to arterial supply, infarcts equally (50%) involved perforators from the lateral lenticulostriate and posterior cerebral (PCA)/basilar artery (BA) followed by medial lenticulostriate arteries (23%). MRA was available in 74.4% and abnormal in 43.2%. The middle cerebral artery was frequently involved (76%) followed by the anterior cerebral artery (38%), internal carotid artery (31%), PCA and BA. Six had diffuse narrowing with a paucity of distal vessels. Cerebral infarction was associated with hydrocephalus ( p = .0019) and vasculitis ( p < .001). Conclusion In TBM, strokes are common and mainly involve the perforators and cortical branches. MR is the imaging modality of choice for early diagnosis and timely management.

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confidence: 85%

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confidence: 99%

Cerebrovascular complications in tuberculous meningitis—A magnetic resonance imaging study in 90 patients from a tertiary care hospital

et al. 2019

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“…CVST can be caused by various disorders of hypercoagulable states, head trauma, intracranial procedures, brain tumors, abscess, and bacterial meningitis [ 12 ]. Since most CVST cases with TB occur as a complication of tuberculous meningitis [ 2 , 13 , 14 ], it may be possible that our patient suffered from tuberculosis meningitis. However, we could not perform a lumbar puncture for cerebrospinal fluid analysis because of the urgent need for anticoagulation therapy.…”

Section: Discussionmentioning

confidence: 99%

A Case of Tuberculosis-related Cerebral Venous Sinus Thrombosis and Pulmonary Thromboembolism Successfully Treated with Edoxaban

Nishino

Akimoto

Mitsuoka

et al. 2022

Respiratory Medicine Case Reports

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“…The decrease of anticoagulants and the increase of procoagulant factor (mainly factor V III) activity in patients with TBM lead to blood hypercoagulability and thrombosis [ 10 ]. In addition, TBM directly compresses the venous sinus by forming granulation tissue or abscess, and it can also lead to thrombosis by changing hemodynamics [ 11 ]. The clinical diagnosis of intracranial venous thrombosis depends on imaging examination [ 12 ].…”

Section: Intracranial Venous Thrombosismentioning

confidence: 99%

The rare manifestations in tuberculous meningoencephalitis: a review of available literature

Liu

Tan

et al. 2023

Annals of Medicine

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Aim: Tuberculous meningitis is an infectious disease of the central nervous system caused by Mycobacterium tuberculosis (M. tuberculosis). It mainly involves the meninges and brain parenchyma, as well as the spinal cord and meninges; Disability and mortality rates are high. In recent years, due to the increase of drug-resistant tuberculosis patients, population mobility and the prevalence of acquired immune deficiency syndrome, the incidence rate of tuberculosis has increased significantly, and tuberculous meningitis has also increased. Methods: At present, tuberculosis is still a worldwide infectious disease that seriously threatens human health, especially in underdeveloped and developing countries. China is the largest developing country in the world with a large population. Results: The situation of tuberculosis prevention and control is grim. Its disability rate is the highest in tuberculosis infection. In addition to the common non-specific manifestations, tuberculous meningoencephalitis may also have rare manifestations of stroke, hearing loss and visual loss. Conclusion: Understanding and timely improvement of corresponding examinations and targeted treatment will help improve the prognosis of patients.

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Cerebral venous thrombosis associated with tuberculous meningitis: a rare complication of a common disease

Cited by 11 publications

References 3 publications

Cerebrovascular complications in tuberculous meningitis—A magnetic resonance imaging study in 90 patients from a tertiary care hospital

Cerebrovascular complications in tuberculous meningitis—A magnetic resonance imaging study in 90 patients from a tertiary care hospital

A Case of Tuberculosis-related Cerebral Venous Sinus Thrombosis and Pulmonary Thromboembolism Successfully Treated with Edoxaban

The rare manifestations in tuberculous meningoencephalitis: a review of available literature

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