Cerebral venous thrombosis as an initial manifestation of acute myeloid leukemia

Tang, Andy Sing Ong; Yeo, Siaw Tze; Law, Wan Chung; Chew, Lee Ping

doi:10.1093/omcr/omy118

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…23 The remaining reports described CVT secondary to AML, and the patients were treated with anticoagulation, except for 1 unique case report in which suction thrombectomy was performed. [24][25][26][27]…”

Section: Literature Review Resultsmentioning

confidence: 99%

Concomitant central venous sinus thrombosis and subdural hematoma in acute promyelocytic leukemia: middle meningeal artery embolization enables safe anticoagulation. Illustrative case

Maini¹,

Afzal²,

Giurgiutiu³

et al. 2021

Journal of Neurosurgery: Case Lessons

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BACKGROUND Acute promyelocytic leukemia (APL) has long been associated with coagulation disorders. The proposed mechanism is a combination of fibrinolysis, proteolysis, platelet dysfunction, thrombocytopenia, and possibly disseminated intravascular coagulation. Hemorrhagic complications are prominent. OBSERVATIONS In this case, a 25-year-old female with newly diagnosed APL developed extensive cerebral venous thrombosis (CVT) and was initiated on a protocol with idarubicin and all-trans retinoic acid. The general recommendation for treating CVT is anticoagulation to stabilize the existing thrombus and prevent propagation. The patient was initiated on a heparin drip, but her clinical course was complicated by subdural hemorrhage (SDH) and epidural hemorrhage in the setting of thrombocytopenia. Anticoagulation was held, and her CVT propagated on follow-up imaging. To restart anticoagulation for CVT with a limited risk of SDH, the authors pursued middle meningeal artery (MMA) embolization. The patient was transitioned to apixaban and discharged to home. LESSONS MMA embolization enables safe anticoagulation in patients with concomitant CVT and SDH. The authors report the complex clinical course and effective management of this rare clinical scenario.

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Section: Literature Review Resultsmentioning

confidence: 99%

Concomitant central venous sinus thrombosis and subdural hematoma in acute promyelocytic leukemia: middle meningeal artery embolization enables safe anticoagulation. Illustrative case

Maini¹,

Afzal²,

Giurgiutiu³

et al. 2021

Journal of Neurosurgery: Case Lessons

View full text Add to dashboard Cite

show abstract

“…82 Thus far, several investigations have documented the occurrence of venous stroke in relation to acute promyelocytic leukemia (APL) and acute lymphoblastic leukemia (ALL), whereas there exists a paucity of reports pertaining to acute myeloid leukemia (AML) or chronic leukemias such as chronic myeloid leukemia and chronic lymphocytic leukemia with CVT. 88,89 However, there are currently no reported cases of chronic leukemias such as chronic myeloid leukemia and chronic lymphocytic leukemia combined with venous stroke. APL or ALL is a relevant cause of venous stroke in children and young adults.…”

Section: Venous Stroke In Patients With Leukemiamentioning

confidence: 99%

Cerebral venous thrombosis in patients with autoimmune disease, hematonosis or coronavirus disease 2019: Many familiar faces and some strangers

et al. 2023

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BackgroundCerebral venous thrombosis, a rare stroke, is characterized by neurological dysfunction caused by bleeding and/or infarction resulting from venous sinus thrombosis, the so‐called venous stroke. Current guidelines recommend anticoagulants as first‐line therapy in the treatment of venous stroke. With complicated causes of cerebral venous thrombosis, treatment is difficult, especially when combined with autoimmune diseases, blood diseases, and even COVID‐19.AimsThis review summarizes the pathophysiological mechanisms, epidemiology, diagnosis, treatment, and clinical prognosis of cerebral venous thrombosis combined with autoimmune diseases, blood diseases, or infectious diseases such as COVID‐19.ConclusionA systematic understanding of particular risk factors that should not be neglected when unconventional cerebral venous thrombosis occurs and for a scientific understanding of pathophysiological mechanisms, clinical diagnosis, and treatment, thus contributing to knowledge on special types of venous stroke.

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Cerebral venous thrombosis as an initial manifestation of acute myeloid leukemia

Cited by 2 publications

References 16 publications

Concomitant central venous sinus thrombosis and subdural hematoma in acute promyelocytic leukemia: middle meningeal artery embolization enables safe anticoagulation. Illustrative case

Concomitant central venous sinus thrombosis and subdural hematoma in acute promyelocytic leukemia: middle meningeal artery embolization enables safe anticoagulation. Illustrative case

Cerebral venous thrombosis in patients with autoimmune disease, hematonosis or coronavirus disease 2019: Many familiar faces and some strangers

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