Cerebral venous thrombosis as a complication of plasmodium vivax Malaria: A report of 2 cases

Srivastava, MV Padma; Agarwal, Ayush; Murali, Suhas; Warrier, Anand R; A, Thomas; Antil, Yamini; Chadha, Aanchal; Vishnu, VenugopalanY; Garg, Ajay

doi:10.4103/aian.aian_996_21

Cited by 1 publication

(3 citation statements)

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“…A hypercoagulable state secondary to severe malaria is thought to have been the cause of this rare and potentially fatal complication. 4 In addition, there were additional case reports of cerebral venous thrombosis in patients with P. vivax malaria among patients from India 5 and there was a case report of sagittal sinus thrombosis associated with severe P. vivax malaria in a patient from Columbia. 6 …”

Section: Discussionmentioning

confidence: 99%

“…Hypercoagulable states due to malaria usually occur in the microvasculature. However, there are several cases of intracranial venous thrombosis due to Plasmodium falciparum and P. vivax malaria [4][5][6] and there was also one case report of pulmonary thromboembolism (PTE) due to P. falciparum. 7 To the best of our knowledge, there have not been case reports of P. vivax malaria associated with PTE; however, P. vivax has been reported to cause acute lung injury and other serious complications.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pulmonary thromboembolism as a rare complication of Plasmodium vivax malaria: A case report

Solela,

Daba,

Getahun

et al. 2023

Clinical Case Reports

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Key Clinical MessageLow threshold is required to suspect complications of Plasmodium vivax malaria. Pulmonary thromboembolism, though rare, should be considered as its complication in the presence of unexplained and sudden onset shortness of breath.AbstractThe hypercoagulable complications of malaria typically manifest in the microvasculature. However, there are several cases of intracranial venous thrombosis caused by Plasmodium falciparum and Plasmodium vivax malaria, and there was one case report of pulmonary thromboembolism (PTE) due to P. falciparum. A 30‐year‐old Ethiopian male patient presented with sudden onset of shortness of breath for 3 days. He had also high‐grade fever, chills, and rigors associated with loss of appetite and fatigue of similar duration. He was from malaria endemic area. He had a pulse rate of 108 beats per minutes, respiratory rate of 32 breaths per minute, oxygen saturation of 82% with atmospheric air and temperature of 38.9°C. Further examination revealed accentuation of pulmonary component of second heart sound. Complete blood count revealed mild anemia and peripheral blood film showed trophozoites of P. vivax. Pulmonary CT angiography showed filling defects in the right and left pulmonary arteries. The patient was diagnosed to have P. vivax malaria complicated by PTE. He was managed with intranasal oxygen, antimalarial agent, and anticoagulation. Upon serial evaluations on the third week and second month of follow up, he did not have complaints and physical examination was non‐remarkable. Malaria is a protozoan disease with high mortality and morbidity. For a long time, severe cases of malaria were thought to be mostly caused by P. falciparum. However, recent evidences have shown a paradigm shift and we should remember that P. vivax can also cause severe malaria and this can be complicated by hypercoagulable conditions including PTE.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%