Cerebral Venous Sinus Thrombosis in Inflammatory Bowel Disease: A Review of Published Case Reports

Albakr, Aishah; AlMohish, Noor

doi:10.7812/tpp/21.031

Cited by 3 publications

(8 citation statements)

References 62 publications

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“…The sigmoid sinus is an uncommon site of thrombosis, and less than half of patients with sigmoid sinus thrombosis in association with IBD had CD. 4 To the best of our knowledge, here we report the first case presented with both; cerebral venous sinus thrombosis and cerebral arteries thrombosis in a patient with inflammatory bowel disease.…”

Section: Introductionmentioning

confidence: 71%

“…3 Cerebral venous sinus thrombosis (CVST) is unusual to be present in a patient with Crohn's disease and will have an undesirable prognosis if CVST diagnoses are delayed. 4 The most common thrombosed sinus observed in IBD patients is the superior sagittal sinus (71.4%). The sigmoid sinus is an uncommon site of thrombosis, and less than half of patients with sigmoid sinus thrombosis in association with IBD had CD.…”

Section: Introductionmentioning

confidence: 99%

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Left middle cerebral artery and sigmoid sinuses thrombosis in a female patient with Crohn's disease

Aseel Abuhammad,

Mean Abu Iram,

Mohammed Alkhanafsa

et al. 2024

World J. Adv. Res. Rev.

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Introduction: Neurologic manifestations in patients with inflammatory bowel disease (IBD) appear to be more common than in the past. However, vascular events in IBD are still a rare presentation and were reported in few cases. Case presentation: A 48-year-old female patient known case of Crohn’s disease presented with sudden onset aphasia, headache, blurring of vision, and decreased level of consciousness for 2 hours. The patient looked ill, confused, agitated, and aphasic. Neurologic examination shows dysarthria and 0/5 power of the right upper and lower extremity. A brain CT without contrast was ordered and showed acute ischemic stroke. The patient received tPA (alteplase) immediately in the intensive care unit and was under observation. On admission, brain CT angiography, MRI, and MRV were performed, which showed middle cerebral artery and sigmoid sinuses thrombosis. The patient has undergone cerebral catheterization, and an MCA stent was inserted. Post catheterization, the patient’s right-sided extremity power was improved to 3/5. She was discharged from the hospital after 13 days in good general condition except for her expressive aphasia. Conclusion: To the best of our knowledge, here we report the first case presented with both; cerebral venous sinus thrombosis and cerebral arteries thrombosis in a patient with IBD. Clinicians must be considered ischemic stroke in any patients with IBD presented with acute neurological manifestation, and an urgent interventional approach must be performed.

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Section: Introductionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Left middle cerebral artery and sigmoid sinuses thrombosis in a female patient with Crohn's disease

Aseel Abuhammad,

Mean Abu Iram,

Mohammed Alkhanafsa

et al. 2024

World J. Adv. Res. Rev.

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“…Most cases in the inflammatory category had ulcerative colitis or neuro-Behcet’s disease or viral infections mostly varicella zoster virus (VZV). Inflammatory bowel disease and especially ulcerative colitis is a well-known prothrombotic disease, although CVST is a rare extraintestinal complication in these patients [ 13 ]. On the other hand, CVST is reported in 10–30% of neuro-Behcet’s disease cases [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Notably, in COVID-19 infection the frequency of CVST was about 3.5%. Inflammatory vasculopathy and the generation of prothrombotic factors are assumed to be the main culprit for the thrombotic events in inflammatory diseases [ 13 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

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Rare Causes of Cerebral Venus Sinus Thrombosis: A Systematic Review

Theologou

Nteveros

Artemiadis

et al. 2023

Life

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Background: Cerebral venous sinus thrombosis (CVST) is a rare manifestation of thrombosis commonly caused by thrombophilia, hormonal-related factors, non-cerebral malignancy, and hematologic diseases. The aim of this review was to identify and summarize rare CVST cases. Methods: A literature search of the Medline database was performed in November 2022. CVST cases of a common cause were excluded. Demographic and clinical data were extracted. Eligible cases were categorized into inflammatory, primary CNS tumors, post-operative/traumatic, and idiopathic groups to allow statistical group comparisons. Results: 76 cases were analyzed. Idiopathic CVST was most frequently reported followed by inflammatory, post-traumatic/operative and primary CNS tumor causes. The intracranial hemorrhage rate was 23.7% and it was found to increase in the inflammatory group (45.8%). Anticoagulation was used in the majority of cases and it was significantly related to better outcomes. A low rate of anticoagulation use (43.8%) was found among CVST cases in the post-operative/traumatic group. The overall mortality rate was 9.8%. 82.4% of patients showed significant early improvement. Conclusions: Most rare CVST cases were either of idiopathic or inflammatory origin. Interestingly, hemorrhage occurred often he idiopathic CVST cases. A low rate of anticoagulation use in neurosurgical CVST cases after trauma or head surgery was observed.

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Gut dysbiosis-related thrombosis in inflammatory bowel disease: Potential disease mechanisms and emerging therapeutic strategies

Papa,

Santini,

De Lucia

et al. 2023

Thrombosis Research

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Cerebral Venous Sinus Thrombosis in Inflammatory Bowel Disease: A Review of Published Case Reports

Cited by 3 publications

References 62 publications

Left middle cerebral artery and sigmoid sinuses thrombosis in a female patient with Crohn's disease

Left middle cerebral artery and sigmoid sinuses thrombosis in a female patient with Crohn's disease

Rare Causes of Cerebral Venus Sinus Thrombosis: A Systematic Review

Gut dysbiosis-related thrombosis in inflammatory bowel disease: Potential disease mechanisms and emerging therapeutic strategies

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