Cerebral Venous Sinus Thrombosis in a Patient With Graves’ Disease

Hieber, Maren; Lambeck, Johann

doi:10.14740/jem378w

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Coagulopathy is one of the rare manifestations of hyperthyroidism; however, there have been multiple isolated reports of cerebral venous sinus thrombosis associated with a hyperthyroid state [ 1 , 2 ]. Incidentally, there are even fewer case reports reported on the development of pulmonary embolisms (PEs) associated with Graves' disease [ 3 - 5 ].…”

Section: Introductionmentioning

confidence: 99%

Unprovoked Isolated Pulmonary Embolism and Graves’ Disease in a Patient With Dyspnea: A Case Report

Bisural¹,

Acharya²,

Adhikari³

et al. 2022

Cureus

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Graves’ disease is a commonly diagnosed disease with a plethora of manifestations that can lead to its diagnosis. One of the rarer presentations of Graves’ disease is hypercoagulability with the development of spontaneous venous thrombosis. In patients presenting with unprovoked pulmonary embolism, we suggest evaluating the patient’s thyroid function tests as a potential underlying cause. To bring this issue to attention, we are presenting a rare case of isolated spontaneous pulmonary embolism development secondarily to underlying Graves’ disease.

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Section: Introductionmentioning

confidence: 99%

Unprovoked Isolated Pulmonary Embolism and Graves’ Disease in a Patient With Dyspnea: A Case Report

Bisural¹,

Acharya²,

Adhikari³

et al. 2022

Cureus

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“…Existing data indicate a possible association between hyperthyroidism and moderate hypothyroidism with a state of hypercoagulability (6)(7)(8)(9). Furthermore, several case reports describe patients with CVST and the additional condition of hyperthyroidism [e.g., (10)(11)(12)]. In the majority of reported cases, hyperthyroidism was due to Graves' disease.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Diseases Are an Underestimated Risk Factor for Cerebral Venous Sinus Thrombosis

et al. 2020

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Introduction: Cerebral venous sinus thrombosis (CVST) is a rare disease that generally accounts for just 1% of all strokes. Of the multiple risk factors that have been identified, the most common are genetic or acquired thrombophilia and the use of oral contraceptives, while the less common include local infections and mechanical causes. Thyroid diseases have been described as rare risk factors for CVST (<2% of all cases), without exact knowledge of the underlying pathophysiology. This retrospective study aimed to re-evaluate the relevance of thyroid disease as risk factor for CVST, with particular emphasis on hyperthyroidism. Patients and Methods: Confirmed cases of CVST were (re-)evaluated in terms of risk factors including thyroid parameters. Results were compared to previous data from the International Study on CVST. Results: Between 1996 and 2016, 182 patients with confirmed CVST were treated in our hospital with a median age of 44 years and a female proportion of 74.7%. Genetic or acquired thrombophilia along with the use of oral contraceptives were found to be the most common risk factors. Thyroid diseases were present in 20.9% of CVST patients; this included patients with previous (9.9%) and current thyroid dysfunction (11%). Discussion and Conclusions: Thyroid diseases may represent a more common risk factor for CVST than previously described. This holds true even if patients with current thyroid dysfunction are purely taken into account. However, 58% of patients had more than one additional risk factor, suggesting a multifactorial hypercoagulability.

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Cerebral Venous Thrombosis during Thyrotoxicosis: Case Report and Literature Update

Raho,

Antonioni,

Cotta Ramusino

et al. 2023

JPM

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Cerebral venous thrombosis (CVT) is a rare cause of stroke, particularly in young adults. Several known thrombophilic conditions may lead to an increased CVT risk. Interestingly, few cases in the literature have reported an association between CVT and thyrotoxicosis. Here, we describe the case of a young woman with CVT and concomitant thyrotoxicosis, without any other known prothrombotic conditions. We also performed a literature review of CVT cases and hyperthyroidism, searching for all articles published in peer-reviewed journals. We identified 39 case reports/case series concerning patients with CVT associated with thyrotoxicosis, highlighting, in most cases, the association with additional known prothrombotic factors. We then discussed the possible mechanisms by which hyperthyroidism could underlie a pro-coagulative state resulting in CVT. Thyroid disease might be a more common prothrombotic risk factor than expected in determining CVT. However, in most cases, a coexistence of multiple risk factors was observed, suggesting a multifactorial genesis of the disorder. We hope that this work may alert clinicians to consider thyrotoxicosis as a potential risk factor for CVT, even in patients who apparently have no other pro-coagulative conditions.

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Cerebral Venous Sinus Thrombosis in a Patient With Graves’ Disease

Cited by 3 publications

References 9 publications

Unprovoked Isolated Pulmonary Embolism and Graves’ Disease in a Patient With Dyspnea: A Case Report

Unprovoked Isolated Pulmonary Embolism and Graves’ Disease in a Patient With Dyspnea: A Case Report

Thyroid Diseases Are an Underestimated Risk Factor for Cerebral Venous Sinus Thrombosis

Cerebral Venous Thrombosis during Thyrotoxicosis: Case Report and Literature Update

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