Cerebral Venous Sinus Thrombosis Associated With Iron Deficiency-Two Case Reports-

Kinoshita, Yusuke; Taniura, Seijiro; Shishido, Hisashi; Nojima, T; Kamitani, Hideki; Watanebe, Takashi

doi:10.2176/nmc.46.589

Cited by 36 publications

(31 citation statements)

References 14 publications

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“…This is usually mild, although severe iron deficiency has been documented as causing marked thombocytosis (Ͼ1 million platelets/l) complicated by central retinal vein occlusion [39]. Cases of cerebral venous sinus thrombosis associated with iron deficiency and a normal platelet count have also been reported [40]. Among six children with iron deficiency and ischemic stroke or venous thrombosis, four had concomitant thrombocytosis [41].…”

Section: Iron Thrombocytosis and Cardiovascular Eventsmentioning

confidence: 99%

Iron Metabolism, Iron Deficiency, Thrombocytosis, and the Cardiorenal Anemia Syndrome

2009

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In treating moderate to severe anemia of chronic kidney disease (CKD), oral iron is effective only in a minority of nondialysis patients. Intravenous iron is more effective and can raise levels of hemoglobin even without the use of erythropoiesis-stimulating agents (ESAs). Unfortunately, the current assays of iron status that are presently widely available are not especially helpful in predicting response. In patients on dialysis, i.v. iron is effective over a wide range of serum ferritin from <100 ng/ml to 800 ng/ml. None of the three available randomized controlled trials comparing oral with i.v. iron showed evidence of nephrotoxicity caused by i.v. iron.Iron deficiency is a risk factor for thrombocytosis and should, wherever possible, be avoided. Optimal coadministration of iron may reduce the risk for ESA-driven cardiovascular events. Increased total body iron stores (imperfectly reflected by serum ferritin levels in CKD) do not appear to be related to such events or hospitalization in CKD; it is unclear what other risk factors and mechanisms need to be considered.In the appreciable proportion of patients with both renal and cardiac dysfunction, management is further complicated by a vicious circle (which can be characterized as cardiorenal anemia syndrome) in which CKD, heart failure, and anemia exacerbate each other. In such patients, correction of anemia appears to improve cardiac function and quality of life without a greater risk for adverse events. The Oncologist 2009;14(suppl 1):22-33

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Section: Iron Thrombocytosis and Cardiovascular Eventsmentioning

confidence: 99%

Iron Metabolism, Iron Deficiency, Thrombocytosis, and the Cardiorenal Anemia Syndrome

2009

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“…It is interesting to note that although with different pathogenic mechanisms, both iron deficiency and overload have been associated with an increased thrombotic risk in experimental and clinical studies. Thrombotic complications reported in iron deficient children and adults in several studies [8,15]. Many cases showed secondary thrombocytosis.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore abnormality in platelet count and function cause thrombosis and setting in atherosclerosis disease [6]. Hypercoagulability may be affected by iron deficiency through altering flow of blood in vessels due to increased viscosity and reduced deformability of microcytic red blood cells [7,8]. Thrombosis gene markers i.e.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Factor V Leiden-G1691A and MTHFR-C677T Thrombosis Gene Modifier in Iron Deficiency Anemia: A Pathophysiological Effect in Indian Isolates

2016

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Normal iron levels are required to prevent thrombocytosis by inhibiting thrombopoiesis. Thrombocytosis is usually associated with a mild iron deficiency and is the result of a lack of inhibition of thrombopoiesis. Study participants were 430 iron deficiency anemia (IDA) patients. Ten (10) mL of venous blood were collected for the subjects. Ferritin analysis was done by ELISA method while Hemogram analysis was done by auto-analyzer. Factor V Leiden, PRTG20210A, and MTHFR C677T genotype analysis was performed by PCR-RFLP method. Among the patients, 9 were heterozygous (G[A) and 2 were homozygous (A[A) carrier of FV Leiden; while 20 were heterozygous (C[T) and 3 were homozygous (T[T) for MTHFR polymorphism. None of the patient was identified with PT mutation. Patients with thrombosis gene marker had lower hemoglobin, mean corpuscular volume, mean corpuscular haemoglobin levels, and mean corpuscular hemoglobin concentration than patients without thrombosis gene marker. Serum ferritin was elevated in subject with the absence of thrombosis gene markers. Our data suggest a high impact of inherited hypercoagulability risk factors in the pathogenesis of IDA and its complications.

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“…However, only a few cases of adults with IDA have been reported (Balci et al, 2007;Ho et al, 2008;Ogata et al, 2008;Kinoshita et al, 2006;Aoki & Sakai, 1989). However, some of these cases were accompanied by other recognized risk factors of CVT, such as dehydration (Kinoshita et al, 2006), a hypercoagulable state (acquired protein C and protein S deficiency) (Ho et al, 2008), and cryoglobulinemia (Ho et al, 2008). These factors may have synergistic effects in addition to IDA and contributed to the CVT.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Venous Thrombosis Secondary to Severe Iron Deficiency Anemia: A Case Study

Busani¹,

Scott²,

Neely³

et al. 2012

CCO

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Cerebral venous thrombosis (CVT) has been associated with numerous etiologies and a myriad of symptoms. Although CVT in association with iron deficiency anemia (IDA) has been observed primarily in pediatric patients, very few cases have been reported in adults. Herein, we describe an encounter with a 28 year-old female who presented solely with a new onset headache due to transverse sinus thrombosis. Thrombophilia work-up was normal. She had no identifiable acquired causes of thrombosis. The patient demonstrated severe iron deficiency anemia secondary to myoma uteri causing menorrhagia.

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Cerebral Venous Sinus Thrombosis Associated With Iron Deficiency-Two Case Reports-

Cited by 36 publications

References 14 publications

Iron Metabolism, Iron Deficiency, Thrombocytosis, and the Cardiorenal Anemia Syndrome

Iron Metabolism, Iron Deficiency, Thrombocytosis, and the Cardiorenal Anemia Syndrome

Prevalence of Factor V Leiden-G1691A and MTHFR-C677T Thrombosis Gene Modifier in Iron Deficiency Anemia: A Pathophysiological Effect in Indian Isolates

Cerebral Venous Thrombosis Secondary to Severe Iron Deficiency Anemia: A Case Study

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